Cited by 272Genetics, Aging, and Longevity in Model OrganismsDietary Effects on HealthCircadian rhythm and melatonin

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Time-restricted feeding attenuates age-related cardiac decline in Drosophila

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Gill, Shubhroz, Le, Hiep D., Melkani, Girish C., Panda, Satchidananda·2015·Science

DOI 10.1126/science.1256682PMC PMC4578815

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Abstract

Circadian clocks orchestrate periods of rest or activity and feeding or fasting over the course of a 24-hour day and maintain homeostasis. To assess whether a consolidated 24-hour cycle of feeding and fasting can sustain health, we explored the effect of time-restricted feeding (TRF; food access limited to daytime 12 hours every day) on neural, peripheral, and cardiovascular physiology in Drosophila melanogaster. We detected improved sleep, prevention of body weight gain, and deceleration of cardiac aging under TRF, even when caloric intake and activity were unchanged. We used temporal gene expression profiling and validation through classical genetics to identify the TCP-1 ring complex (TRiC) chaperonin, the mitochondrial electron transport chain complexes, and the circadian clock as pathways mediating the benefits of TRF.

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Authors: Gill, S., Le, H. D., Melkani, G. C., & Panda, S.
Affiliations: Salk Institute for Biological Studies (US)
San Diego State University (US)
Corresponding author: Melkani, Girish C.
Panda, Satchidananda
ORCID: Le, Hiep D.
Melkani, Girish C.
Panda, Satchidananda
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2015-03-13
Volume: 347
Issue: 6227
Pages: 1265-1269
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1256682
PMC: PMC4578815
OpenAlex: W1975439065
Cited by: 272
References: 23
Citations by year: 2026: 11 · 2025: 21 · 2024: 28 · 2023: 26 · 2022: 33 · 2021: 27 · 2020: 25 · 2019: 22 · 2018: 22 · 2017: 23 · 2016: 26 · 2015: 8
FWCI: 10.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 366 d)
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (DK091618, EY016807, NS066457, RR032100, P30 CA014195, P30 EY019005)
American Federation for Aging Research (M14322)
American Heart Association (13BGIA17260057)
H. A. and Mary K. Chapman Trust
Leona M. and Harry B. Helmsley Charitable Trust (2012-PG-MED002)
Aginsky Research Scholar Award
Glenn Center for Aging
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: time-restricted feeding, cardiac aging, circadian clock, Drosophila melanogaster, sleep, weight gain, TRiC chaperonin, mitochondrial electron transport chain, feeding-fasting cycle
MeSH terms: Animals, Energy Intake, Drosophila melanogaster, Electron Transport, Feeding Behavior, Flight, Animal, Heart, Male, Mitochondria, Myocardial Contraction, Sleep, Weight Gain, Chaperonins, Drosophila Proteins, Metabolic Networks and Pathways, Circadian Clocks, Transcriptome

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Time-restricted feeding attenuates age-related cardiac decline in Drosophila

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