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m 6 A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

Geula, Shay, Moshitch-Moshkovitz, Sharon, Dominissini, Dan, Mansour, Abed AlFatah, Kol, Nitzan, Salmon-Divon, Mali, Hershkovitz, Vera, Peer, Eyal, Mor, Nofar, Manor, Yair S., Ben-Haim, Moshe Shay, Eyal, Eran, Yunger, Sharon, Pinto, Yishay, Jaitin, Diego Adhemar, Viukov, Sergey, Rais, Yoach, Krupalnik, Vladislav, Chomsky, Elad, Zerbib, Mirie, Maza, Itay, Rechavi, Yoav, Massarwa, Rada, Hanna, Suhair, Amit, Ido, Levanon, Erez Y., Amariglio, Ninette, Stern-Ginossar, Noam, Novershtern, Noa, Rechavi, Gideon, Hanna, Jacob H.·2015·Science

DOI 10.1126/science.1261417

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Abstract

mRNA modification regulates pluripotency: When stem cells progress from an embryonic pluripotent state toward a particular lineage, molecular switches dismantle the transcription factor network that keeps the cell pluripotent. Geula et al. now show that N6-methyladenosine (m6A), a messenger RNA (mRNA) modification present on transcripts of pluripotency factors, drives this transition. Methylation destabilized mRNA transcripts and limited their translation efficiency, which promoted the timely decay of naïve pluripotency. This m6A methylation was also critical for mammalian development. Science , this issue p. 1002

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Authors: Geula, S., Moshitch-Moshkovitz, S., Dominissini, D., Mansour, A. A., Kol, N., Salmon-Divon, M., Hershkovitz, V., Peer, E., Mor, N., Manor, Y. S., Ben-Haim, M. S., Eyal, E., Yunger, S., Pinto, Y., Jaitin, D. A., Viukov, S., Rais, Y., Krupalnik, V., Chomsky, E., Zerbib, M., Maza, I., Rechavi, Y., Massarwa, R., Hanna, S., Amit, I., Levanon, E. Y., Amariglio, N., Stern-Ginossar, N., Novershtern, N., Rechavi, G., & Hanna, J. H.
Affiliations: The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer, Israel, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA.
Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
The Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2015-02-27
Volume: 347
Issue: 6225
Pages: 1002-1006
ISSN: 0036-8075
1095-9203
DOI: 10.1126/science.1261417
Cited by: 1,533
References: 16
Language: en
Licence: www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 365 d)
Funders: Flight Attendant Medical Research Institute
Israel Science Foundation (1667/12, 41/11, 1796/12)
Israeli Centers of Excellence (I-CORE) Program
Ernest and Bonnie Beutler Research Program

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m 6 A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

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