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Melatonin Synthesis in the Pineal Gland: Control by Light
Abstract
In rats placed in continuous darkness for 6 days, there is a striking increase in the activity of melatonin-synthesizing-enzyme (hydroxyindole-O-methyl transferase) in the pineal gland, but no change in the activity of monoamine oxidase. Since melatonin appears to have a hormonal role in mammals, and its synthesis is confined to the pineal gland, the inhibition of hydroxyindole-O-methyl transferase by light may constitute a mechanism of neuroendocrine regulation.
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Citations
Cited by
Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*
REITER, R. J. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-151 · Cited by 2,192
Light Suppresses Melatonin Secretion in Humans
Lewy, A. J., Wehr, T. A., Goodwin, F. K., Newsome, D. A., & Markey, S. P. (1980) · Science · doi:10.1126/science.7434030 · Cited by 1,913
Axelrod, J. (1974) · Science · doi:10.1126/science.184.4144.1341 · Cited by 874
Self-citationSimonneaux, V., & Ribelayga, C. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.2 · Cited by 740
Daytime melatonin and light independently affect human alertness and body temperature
Lok, R., van Koningsveld, M. J., Gordijn, M. C. M., Beersma, D. G. M., & Hut, R. A. (2019) · Journal of Pineal Research · doi:10.1111/jpi.12583 · Cited by 81
Metadata
- Authors
- Wurtman, R. J., Axelrod, J., & Phillips, L. S.
- Venue
- Science
- Published
- 1963-11-22
- Volume
- 142
- Issue
- 3595
- Pages
- 1071-1073
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005840740
- Cited by
- 432
- References
- 0
- FWCI
- 11.07
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
