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The Nuclear Membrane
Abstract
The nuclear membrane forms a major barrier within the cell, permitting levels of regulation not found in prokaryotes. The dynamics and diverse functions of the nuclear membrane and its associated structures are considered in this review. The role of the nuclear pore complex in selective transport across the nuclear membrane has been studied to a considerable degree; however, many crucial questions remain. Components of a signal transduction mechanism are associated with the nucleus, suggesting that nuclear functions may be influenced directly by this system. The involvement of the heat shock cognate protein Hsc70 in nuclear protein import is discussed, and a specific signal-presentation role for this protein is proposed.
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Cited by
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Macromolecular Domains within the Cell Nucleus
Spector, D. L. (1993) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.09.110193.001405 · Cited by 601
The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm.
Meyer, B. E., & Malim, M. H. (1994) · Genes & Development · doi:10.1101/gad.8.13.1538 · Cited by 305
Humbert, J.-P., Matter, N., Artault, J.-C., Köppler, P., & Malviya, A. N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.1.478 · Cited by 277
Distinguishing Hyperglycemic Changes by Set7 in Vascular Endothelial Cells
Okabe, J., Orlowski, C., Balcerczyk, A., Tikellis, C., Thomas, M. C., Cooper, M. E., & El-Osta, A. (2012) · Circulation Research · doi:10.1161/circresaha.112.266171 · Cited by 180
Metadata
- Authors
- Dingwall, C., & Laskey, R.
- Venue
- Science
- Published
- 1992-11-06
- Volume
- 258
- Issue
- 5084
- Pages
- 942-947
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2035091883
- Cited by
- 206
- References
- 0
- FWCI
- 11.32
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
