Distinguishing Hyperglycemic Changes by Set7 in Vascular Endothelial Cells

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667 · see citing works

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

(1998) · The Lancet · doi:10.1016/s0140-6736(98)07019-6 · Cited by 20,023 · see citing works

The language of covalent histone modifications

Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679 · see citing works

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.

Turner, R. C., Fox, C., Matthews, McElroy, H. H., Cull, C. A., Holman, R. R., Neil, P., Hadden, D. R., Wright, D., Manley, E., et al. (1998) · The Lancet · Cited by 8,419 · see citing works

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277 · see citing works

The diverse functions of histone lysine methylation

Martin, C., & Zhang, Y. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1761 · Cited by 2,066 · see citing works

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

El-Osta, A., Brasacchio, D., Yao, D., Pocai, A., Jones, P. L., Roeder, R. G., Cooper, M. E., & Brownlee, M. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081188 · Cited by 1,115 · see citing works

Extraction, purification and analysis of histones

Shechter, D., Dormann, H. L., Allis, C. D., & Hake, S. B. (2007) · Nature Protocols · doi:10.1038/nprot.2007.202 · Cited by 1,054 · see citing works

Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells

Du, X., Matsumura, T., Edelstein, D., Rossetti, L., Zsengellér, Z. K., Szabó, C., & Brownlee, M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18127 · Cited by 832 · see citing works

Regulation of p53 activity through lysine methylation

Chuikov, S., Kurash, J. K., Wilson, J. R., Xiao, B., Justin, N., Ivanov, G. S., McKinney, K. M., Tempst, P., Prives, C. L., Gamblin, S. J., et al. (2004) · Nature · doi:10.1038/nature03117 · Cited by 820 · see citing works

Risk of Cardiovascular and All-Cause Mortality in Individuals With Diabetes Mellitus, Impaired Fasting Glucose, and Impaired Glucose Tolerance: The Australian Diabetes, Obesity, and Lifestyle Study (AusDiab)

Barr, E. L. M., Zimmet, P. Z., Welborn, T. A., Jolley, D., Magliano, D. J., Dunstan, D. W., Cameron, A. J., Dwyer, T., Taylor, H. R., Tonkin, A. M., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.685628 · Cited by 719 · see citing works

Dynamic Regulation of Histone Lysine Methylation by Demethylases

Shi, Y., & Whetstine, J. R. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.12.010 · Cited by 710 · see citing works

Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formationPreprint

Nishioka, K., Chuikov, S., Sarma, K., Erdjument‐Bromage, H., Allis, C. D., Tempst, P., & Reinberg, D. (2002) · Genes & Development · doi:10.1101/gad.967202 · Cited by 558 · see citing works

Purification and Functional Characterization of a Histone H3-Lysine 4-Specific Methyltransferase

Wang, H., Cao, R., Li, X., Erdjument‐Bromage, H., Borchers, C. H., Tempst, P., & Zhang, Y. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00405-1 · Cited by 539 · see citing works

Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

Brasacchio, D., Okabe, J., Tikellis, C., Balcerczyk, A., George, P., Baker, E. K., Calkin, A. C., Brownlee, M., Cooper, M. E., & El‐Osta, A. (2009) · Diabetes · doi:10.2337/db08-1666 · Cited by 533 · see citing works

Effects of Diabetes and Level of Glycemia on All-Cause and Cardiovascular Mortality: The San Antonio Heart Study

Wei, M., Gaskill, S. P., Haffner, S., & Stern, M. (1998) · Diabetes Care · doi:10.2337/diacare.21.7.1167 · Cited by 515 · see citing works

A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasmPreprint

Cáceres, J. F., Screaton, G. R., & Krainer, A. R. (1998) · Genes & Development · doi:10.1101/gad.12.1.55 · Cited by 500 · see citing works

Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes

Villeneuve, L. M., Reddy, M. A., Lanting, L. L., Wang, M., Li, M., & Natarajan, R. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803623105 · Cited by 412 · see citing works

A novel role for shuttling SR proteins in mRNA translationPreprint

Sanford, J. R., Gray, N. K., Beckmann, K., & Cáceres, J. F. (2004) · Genes & Development · doi:10.1101/gad.286404 · Cited by 407 · see citing works

Structure and catalytic mechanism of the human histone methyltransferase SET7/9

Xiao, B., Jing, C., Wilson, J. R., Walker, P. A., Vasisht, N., Kelly, G. P., Howell, S. A., Taylor, I. A., Blackburn, G. M., & Gamblin, S. J. (2003) · Nature · doi:10.1038/nature01378 · Cited by 384 · see citing works

Role of the Histone H3 Lysine 4 Methyltransferase, SET7/9, in the Regulation of NF-κB-dependent Inflammatory Genes

Li, Y., Reddy, M. A., Miao, F., Shanmugam, N., Yee, J.-K., Hawkins, D., Ren, B., & Natarajan, R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802800200 · Cited by 353 · see citing works

Structural and Sequence Motifs of Protein (Histone) Methylation Enzymes

Cheng, X., Collins, R. E., & Zhang, X. (2005) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.34.040204.144452 · Cited by 349 · see citing works

Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells

Estève, P., Chin, H. G., Benner, J. S., Feehery, G. R., Samaranayake, M., Horwitz, G. A., Jacobsen, S. E., & Pradhan, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810362106 · Cited by 319 · see citing works

The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm.Preprint

Meyer, B. E., & Malim, M. H. (1994) · Genes & Development · doi:10.1101/gad.8.13.1538 · Cited by 305 · see citing works

Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo

Wang, Z., Au, P., Chen, T., Shao, Y., Daheron, L. M., Bai, H., Arzigian, M., Fukumura, D., Jain, R. K., & Scadden, D. T. (2007) · Nature Biotechnology · doi:10.1038/nbt1287 · Cited by 298 · see citing works

Regulation of Estrogen Receptor α by the SET7 Lysine Methyltransferase

Subramanian, K., Jia, D., Kapoor-Vazirani, P., Powell, D. R., Collins, R. E., Sharma, D., Peng, J., Cheng, X., & Vertino, P. M. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.022 · Cited by 291 · see citing works

Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.

Park, J. Y., Takahara, N., Gabriele, A., Chou, E. L., Naruse, K., Suzuma, K., Yamauchi, T., Ha, S. W., Meier, M., Rhodes, C. J., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.7.1239 · Cited by 278 · see citing works

UKPDS and the legacy effect

Chalmers, J., & Cooper, M. E. (2008) · New England Journal of Medicine · doi:10.1056/nejme0807625 · Cited by 263 · see citing works

Gene-Specific Modulation of TAF10 Function by SET9-Mediated Methylation

Kouskouti, A., Scheer, E., Staub, A., Tora, L., & Talianidis, I. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00182-0 · Cited by 255 · see citing works

Epigenetic phenomena linked to diabetic complications

Pirola, L., Balcerczyk, A., Okabe, J., & El-Osta, A. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.188 · Cited by 239 · see citing works

Regulation of NF-κB activity through lysine monomethylation of p65

Ea, C.-K., & Baltimore, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910439106 · Cited by 237 · see citing works

Components of the Human SWI/SNF Complex Are Enriched in Active Chromatin and Are Associated with the Nuclear Matrix

Reyes, J. C., Muchardt, C., & Yaniv, M. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.2.263 · Cited by 224 · see citing works

Crystal Structure and Functional Analysis of the Histone Methyltransferase SET7/9

Wilson, J. R., Jing, C., Walker, P. A., Martin, S. R., Howell, S. A., Blackburn, G. M., Gamblin, S. J., & Xiao, B. (2002) · Cell · doi:10.1016/s0092-8674(02)00964-9 · Cited by 223 · see citing works

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cellsPreprint

Pirola, L., Balcerczyk, A., Tothill, R. W., Haviv, I., Kaspi, A., Lunke, S., Ziemann, M., Karagiannis, T. C., Tonna, S. J., Kowalczyk, A., et al. (2011) · Genome Research · doi:10.1101/gr.116095.110 · Cited by 220 · see citing works

Methylation of p53 by Set7/9 Mediates p53 Acetylation and Activity In Vivo

Kurash, J. K., Lei, H., Shen, Q. “., Marston, W. L., Granda, B. W., Fan, H. X., Wall, D., Li, E., & Gaudet, F. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.025 · Cited by 215 · see citing works

Epigenetics

Cooper, M. E., & El‐Osta, A. (2010) · Circulation Research · doi:10.1161/circresaha.110.223552 · Cited by 211 · see citing works

The Nuclear Membrane

Dingwall, C., & Laskey, R. A. (1992) · Science · doi:10.1126/science.1439805 · Cited by 208 · see citing works

Intermittent high glucose enhances ICAM‐1, VCAM‐1, E‐selectin and interleukin‐6 expression in human umbilical endothelial cells in culture: the role of poly(ADP‐ribose) polymerase

Piconi, L., Quagliaro, L., ROS, R. D., Assaloni, R., Giugliano, D., Esposito, K., Szabó, C., & Ceriello, A. (2004) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2004.00835.x · Cited by 197 · see citing works

Differentiation-dependent chromatin alterations precede and accompany transcription of immunoglobulin light chain genes.

Rose, S. M., & Garrard, W. T. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39763-6 · Cited by 164 · see citing works

Structural basis for the methylation site specificity of SET7/9

Couture, J., Collazo, E., Hauk, G., & Trievel, R. C. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1045 · Cited by 152 · see citing works

Methyltransferase Set7/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes

Deering, T. G., Ogihara, T., Trace, A. P., Maier, B., & Mirmira, R. G. (2008) · Diabetes · doi:10.2337/db08-1150 · Cited by 117 · see citing works

Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases

Zhang, X., & Bruice, T. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801788105 · Cited by 74 · see citing works

Histone Lysine Methyltransferase SET7/9: Formation of a Water Channel Precedes Each Methyl Transfer

Zhang, X., & Bruice, T. C. (2007) · Biochemistry · doi:10.1021/bi7014579 · Cited by 46 · see citing works

Acute Hyperglycaemia Induces Changes in the Transcription Levels of 4 Major Genes in Human Endothelial Cells: Macroarrays-based Expression Analysis

Zibara, K., Belaiba, S.-R., McGregor, J. L., & Chettab, K. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1612957 · Cited by 34 · see citing works

The oxidative stress of hyperglycemia and the inflammatory process in endothelial cells

Muniandy, S., Qvist, R., Yan, G. O. S., Bee, C. J., Chu, Y. K., & Rayappan, A. V. (2009) · The Journal of Medical Investigation · doi:10.2152/jmi.56.6 · Cited by 24 · see citing works

Mechanism of Product Specificity of AdoMet Methylation Catalyzed by Lysine Methyltransferases: Transcriptional Factor p53 Methylation by Histone Lysine Methyltransferase SET7/9

Zhang, X., & Bruice, T. C. (2008) · Biochemistry · doi:10.1021/bi702370p · Cited by 22 · see citing works

Limited capacity of the nuclear matrix to bind telomere repeat binding factor TRF1 may restrict the proliferation of mortal human fibroblasts

Okabe, J. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddh032 · Cited by 17 · see citing works

Diabetic kidney disease

Thomas, M. C., Brownlee, M., Suszták, K., Sharma, K., Jandeleit-Dahm, K. A. M., Zoungas, S., Rossing, P. R., Groop, P., & Cooper, M. E. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.18 · Cited by 1,282 · see citing works

The Diabetes Mellitus–Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation

Poznyak, A. V., Grechko, A. V., Poggio, P., Myasoedova, V. A., Alfieri, V., & Orekhov, A. N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051835 · Cited by 1,170 · see citing works

Epigenetics and epigenomics in diabetic kidney disease and metabolic memory

Kato, M. V., & Natarajan, R. D. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0135-6 · Cited by 604 · see citing works

Endothelial Cell Metabolism

Eelen, G., de Zeeuw, P., Treps, L., Harjes, U., Wong, B. W., & Carmeliet, P. (2017) · Physiological Reviews · doi:10.1152/physrev.00001.2017 · Cited by 591 · see citing works

Epigenetic mechanisms in diabetic complications and metabolic memory

Reddy, M. A., Zhang, E., & Natarajan, R. D. (2014) · Diabetologia · doi:10.1007/s00125-014-3462-y · Cited by 498 · see citing works

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Zhong, Q., Xiao, X., Qiu, Y., Xu, Z., Chen, C., Chong, B., Zhao, X., Hai, S., Li, S., An, Z., et al. (2023) · MedComm · doi:10.1002/mco2.261 · Cited by 442 · see citing works

The Circadian Syndrome: is the Metabolic Syndrome and much more!

Zimmet, P., Alberti, K. G. M. M., Stern, N., Bilu, C., El‐Osta, A., Einat, H., & Kronfeld‐Schor, N. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12924 · Cited by 387 · see citing works

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

Gray, S. P., Di Marco, E., Okabe, J., Szyndralewiez, C., Heitz, F., Montezano, A. C., de Haan, J. B., Koulis, C., El-Osta, A., Andrews, K. L., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.132159 · Cited by 386 · see citing works

Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

Jha, J. C., Gray, S. P., Barit, D., Okabe, J., El-Osta, A., Namikoshi, T., Thallas-Bonke, V., Wingler, K., Szyndralewiez, C., Heitz, F., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013070810 · Cited by 352 · see citing works

Epigenetics and Metabolism

Keating, S. T., & El‐Osta, A. (2015) · Circulation Research · doi:10.1161/circresaha.116.303936 · Cited by 315 · see citing works

Targeting epigenetic mechanisms in diabetic wound healing

den Dekker, A. D., Davis, F. M., Kunkel, S. L., & Gallagher, K. A. (2018) · Translational research · doi:10.1016/j.trsl.2018.10.001 · Cited by 238 · see citing works

Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling

Gray, S. P., Di Marco, E., Kennedy, K., Chew, P., Okabe, J., El-Osta, A., Calkin, A. C., Biessen, E. A. L., Touyz, R. M., Cooper, M. E., et al. (2016) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.115.307012 · Cited by 189 · see citing works

( R )-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

Baršytė-Lovejoy, D., Li, F., Oudhoff, M. J., Tatlock, J. H., Dong, A., Zeng, H., Wu, H., Freeman, S. A., Schapira, M., Senisterra, G. A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407358111 · Cited by 187 · see citing works

Impact of Glycemic Variability on Chromatin Remodeling, Oxidative Stress, and Endothelial Dysfunction in Patients With Type 2 Diabetes and With Target HbA1c Levels

Costantino, S., Paneni, F., Battista, R., Castello, L., Capretti, G., Chiandotto, S., Tanese, L., Russo, G., Pitocco, D., Lanza, G. A., et al. (2017) · Diabetes · doi:10.2337/db17-0294 · Cited by 188 · see citing works

The Signaling of Cellular Senescence in Diabetic Nephropathy

Xiong, Y., & Zhou, L. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7495629 · Cited by 185 · see citing works

Knockdown of Glyoxalase 1 Mimics Diabetic Nephropathy in Nondiabetic Mice

Giacco, F., Du, X., D’Agati, V. D., Milne, R. W., Sui, G., Geoffrion, M., & Brownlee, M. (2013) · Diabetes · doi:10.2337/db13-0316 · Cited by 182 · see citing works

Adverse Epigenetic Signatures by Histone Methyltransferase Set7 Contribute to Vascular Dysfunction in Patients With Type 2 Diabetes Mellitus

Paneni, F., Costantino, S., Battista, R., Castello, L., Capretti, G., Chiandotto, S., Scavone, G., Villano, A., Pitocco, D., Lanza, G. A., et al. (2014) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.114.000671 · Cited by 176 · see citing works

The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan

Keating, S. T., Groh, L. A., van der Heijden, C. D. C. C., Rodriguez, H., dos Santos, J. C., Fanucchi, S., Okabe, J., Kaipananickal, H., van Puffelen, J. H., Helder, L. S., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107548 · Cited by 173 · see citing works

Assessment and pathophysiology of microvascular disease: recent progress and clinical implications

Masi, S., Rizzoni, D., Taddei, S., Widmer, R. J., Montezano, A. C. I., Lüscher, T. F., Schiffrin, E. L., Touyz, R. M., Paneni, F., Lerman, A., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa857 · Cited by 162 · see citing works

NADPH Oxidase Nox5 Accelerates Renal Injury in Diabetic Nephropathy

Jha, J. C., Banal, C., Okabe, J., Gray, S. P., Hettige, T., Chow, B. S. M., Thallas‐Bonke, V., de Vos, L. C., Holterman, C. E., Coughlan, M. T., et al. (2017) · Diabetes · doi:10.2337/db16-1585 · Cited by 142 · see citing works

Epigenetic Changes in Diabetes and Cardiovascular Risk

Keating, S. T., Plutzky, J., & El-Osta, A. (2016) · Circulation Research · doi:10.1161/circresaha.116.306819 · Cited by 139 · see citing works

An update on chronic complications of diabetes mellitus: from molecular mechanisms to therapeutic strategies with a focus on metabolic memory

Yang, T., Feng, Q., Guo, F., Shao, M., Song, Y., Ren, G., Zhao, L., Qin, G., & Zhao, Y. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00824-9 · Cited by 144 · see citing works

Myocardin-Related Transcription Factor A Epigenetically Regulates Renal Fibrosis in Diabetic Nephropathy

Xu, H., Wu, X., Qin, H., Tian, W., Chen, J., Sun, L., Fang, M., & Xu, Y. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014070678 · Cited by 127 · see citing works

Trained immunity in atherosclerotic cardiovascular disease

Riksen, N. P., Bekkering, S., Mulder, W. J. M., & Netea, M. G. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00894-y · Cited by 129 · see citing works

Epigenetic Modifications of Keap1 Regulate Its Interaction With the Protective Factor Nrf2 in the Development of Diabetic Retinopathy

Mishra, M., Zhong, Q. P. W., & Kowluru, R. A. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-15193 · Cited by 119 · see citing works

SIRT1, p66Shc, and Set7/9 in Vascular Hyperglycemic Memory

Paneni, F., Volpe, M., Lüscher, T. F., & Cosentino, F. (2013) · Diabetes · doi:10.2337/db12-1648 · Cited by 118 · see citing works

Regulation of Nox enzymes expression in vascular pathophysiology: Focusing on transcription factors and epigenetic mechanisms

Manea, S., Constantin, A. L., Manda, G., Sasson, S., & Manea, A. (2015) · Redox Biology · doi:10.1016/j.redox.2015.06.012 · Cited by 116 · see citing works

Biological processes and signal transduction pathways regulated by the protein methyltransferase SETD7 and their significance in cancer

Batista, I. A., & Helguero, L. A. (2018) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-018-0017-6 · Cited by 106 · see citing works

Epigenetic Modifications in the Pathogenesis of Diabetic Nephropathy

Reddy, M. A., Park, J. T., & Natarajan, R. D. (2013) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2013.05.006 · Cited by 102 · see citing works

Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes

Prattichizzo, F., Giuliani, A., Çeka, A., Rippo, M. R., Bonfigli, A. R., Testa, R., Procopio, A. D., & Olivieri, F. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0090-4 · Cited by 97 · see citing works

The Histone Methyltransferase Enzyme Enhancer of Zeste Homolog 2 Protects against Podocyte Oxidative Stress and Renal Injury in Diabetes

Siddiqi, F. S., Majumder, S., Thai, K., Abdalla, M., Hu, P., Advani, S. L., White, K., Bowskill, B. B., Guarna, G., dos Santos, C. C., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014090898 · Cited by 96 · see citing works

Trained Immunity in Atherosclerotic Cardiovascular Disease

Gomez, D. F., Bekkering, S., Netea, M. G., & Riksen, N. P. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314216 · Cited by 96 · see citing works

Epigenetics and Immunometabolism in Diabetes and Aging

Guzik, T. J., & Cosentino, F. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7299 · Cited by 93 · see citing works

Transcriptional regulation by the Set7 lysine methyltransferase

Keating, S. T., & El‐Osta, A. (2013) · Epigenetics · doi:10.4161/epi.24234 · Cited by 91 · see citing works

Postprandial glucose spikes, an important contributor to cardiovascular disease in diabetes?

Hanssen, N. M. J., Kraakman, M. J., Flynn, M. C., Nagareddy, P. R., Schalkwijk, C. G., & Murphy, A. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.570553 · Cited by 90 · see citing works

GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop

Giacco, F., Du, X., Carratù, A. C., Gerfen, G. J., D’Apolito, M., Giardino, I., Rasola, A., Marin, O., Divakaruni, A. S., Murphy, A. N., et al. (2015) · Diabetes · doi:10.2337/db15-0084 · Cited by 87 · see citing works

Epigenetic changes in diabetes

Keating, S. T., & El‐Osta, A. (2013) · Clinical Genetics · doi:10.1111/cge.12121 · Cited by 86 · see citing works

Epigenetics in diabetic nephropathy, immunity and metabolism

Keating, S. T., van Diepen, J. A., Riksen, N. P., & El-Osta, A. (2018) · Diabetologia · doi:10.1007/s00125-017-4490-1 · Cited by 82 · see citing works

Epigenetic Regulation of S100A9 and S100A12 Expression in Monocyte-Macrophage System in Hyperglycemic Conditions

Mossel, D. M., Moganti, K., Riabov, V., Weiß, C., Kopf, S., Cordero, J., Dobreva, G. D., Rots, M. G., Klüter, H., Harmsen, M. C., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01071 · Cited by 82 · see citing works

Epigenetic modifications in metabolic memory: What are the memories, and can we erase them?

Chen, Z., & Natarajan, R. D. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00201.2022 · Cited by 77 · see citing works

Histone methylation and vascular biology

Wei, X., Yi, X., Zhu, X., & Jiang, D. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00826-4 · Cited by 78 · see citing works

Epigenomes in Cardiovascular Disease

Rosa‐Garrido, M., Chapski, D. J., & Vondriska, T. M. (2018) · Circulation Research · doi:10.1161/circresaha.118.311597 · Cited by 71 · see citing works

Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications

Rajasekar, P., O’Neill, C. L., Eeles, L., Stitt, A. W., & Medina, R. J. (2015) · Journal of Diabetes Research · doi:10.1155/2015/436879 · Cited by 71 · see citing works

Role of epigenetic mechanisms in the development of chronic complications of diabetes

Wegner, M., Neddermann, D., Pioruńska-Stolzmann, M., & Jagodziński, P. P. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.03.019 · Cited by 71 · see citing works

The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart

Mathiyalagan, P., Okabe, J., Chang, L., Su, Y. R., Du, X., & El‐Osta, A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt896 · Cited by 69 · see citing works

Glycemic Memories and the Epigenetic Component of Diabetic Nephropathy

Keating, S. T., & El‐Osta, A. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0383-y · Cited by 69 · see citing works

Emerging Evidence of Epigenetic Modifications in Vascular Complication of Diabetes

Khullar, M., Cheema, B. S., & Raut, S. K. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00237 · Cited by 68 · see citing works

Dicarbonyl stress, protein glycation and the unfolded protein response

Rabbani, N., Xue, M., & Thornalley, P. J. (2021) · Glycoconjugate Journal · doi:10.1007/s10719-021-09980-0 · Cited by 67 · see citing works

Lysine Methyltransferase SETD7 (SET7/9) Regulates ROS Signaling through mitochondria and NFE2L2/ARE pathway

He, S., Owen, D. R., Jelinsky, S. A., & Lin, L.-L. (2015) · Scientific Reports · doi:10.1038/srep14368 · Cited by 67 · see citing works

Mitochondrial health, the epigenome and healthspan

Aon, M. A., Cortassa, S., Juhaszova, M., & Sollott, S. J. (2016) · Clinical Science · doi:10.1042/cs20160002 · Cited by 66 · see citing works

Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relevance in Diabetic Retinopathy

Ruiz, M. A., Feng, B., & Chakrabarti, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123987 · Cited by 66 · see citing works

Epigenetic Histone Modifications Involved in Profibrotic Gene Regulation by 12/15-Lipoxygenase and Its Oxidized Lipid Products in Diabetic Nephropathy

Yuan, H., Reddy, M. A., Deshpande, S., Jia, Y., Park, J. T., Lanting, L. L., Jin, W. L., Kato, M. V., Xu, Z. G., Das, S., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6372 · Cited by 65 · see citing works

Diabetes Alters Activation and Repression of Pro- and Anti-Inflammatory Signaling Pathways in the Vasculature

Marco, E. D., Gray, S. P., & Jandeleit-Dahm, K. A. M. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00068 · Cited by 62 · see citing works

The anti-cancer drug doxorubicin induces substantial epigenetic changes in cultured cardiomyocytes

Hanf, A., Oelze, M. W., Manea, A., Li, H., Münzel, T. F., & Daiber, A. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.108834 · Cited by 61 · see citing works

ANRIL regulates production of extracellular matrix proteins and vasoactive factors in diabetic complications

Thomas, A. A., Feng, B., & Chakrabarti, S. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00268.2017 · Cited by 61 · see citing works

Oxidative-stress-induced epigenetic changes in chronic diabetic complications

Feng, B., Ruiz, M. A., & Chakrabarti, S. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0251 · Cited by 59 · see citing works

Aberrant DNA methylation patterns in diabetic nephropathy

Maghbooli, Z., Larijani, B. A., Emamgholipour, S., Amini, M., Keshtkar, A., & Pasalar, P. (2014) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/2251-6581-13-69 · Cited by 56 · see citing works

Histone Methyltransferase SET1 Mediates Angiotensin II–Induced Endothelin-1 Transcription and Cardiac Hypertrophy in Mice

Yu, L., Yang, G., Weng, X., Liang, P., Li, L., Li, J., Fan, Z., Tian, W., Wu, X., Xu, H., et al. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305230 · Cited by 57 · see citing works

Epigenetic changes in renal genes dysregulated in mouse and rat models of type 1 diabetes

Komers, R., Mar, D., Denisenko, O. N., Xu, B., Oyama, T., & Bomsztyk, K. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2013.47 · Cited by 52 · see citing works

Endothelial progenitor cells dysfunction and impaired tissue reparation: The missed link in diabetes mellitus development

Berezin, A. Е. (2016) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2016.08.007 · Cited by 49 · see citing works

Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus

Ramírez‐Alarcón, K., Victoriano, M., Mardones, L., Villagrán, M., Al‐Harrasi, A., Al-Rawahi, A. N., Martins, N. A., Sharifi‐Rad, J., & Martorell, M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.656978 · Cited by 48 · see citing works

Megakaryocytic Leukemia 1 Directs a Histone H3 Lysine 4 Methyltransferase Complex to Regulate Hypoxic Pulmonary Hypertension

Chen, D., Yang, Y., Cheng, X. F., Fang, F., Xu, G., Yuan, Z., Xia, J., Kong, H., Xie, W., Wang, H., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.04585 · Cited by 47 · see citing works

SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation

Lee, J., Shao, N., Paik, D. T., Wu, H., Guo, H., Termglinchan, V., Churko, J. M., Kim, Y., Kitani, T., Zhao, M., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.02.005 · Cited by 48 · see citing works

Cell-specific epigenetic changes in atherosclerosis

Khan, A. W., Paneni, F., & Jandeleit-Dahm, K. A. M. (2021) · Clinical Science · doi:10.1042/cs20201066 · Cited by 46 · see citing works

Epigenetic Mechanisms in Diabetic Kidney Disease

Thomas, M. C. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0723-9 · Cited by 46 · see citing works

Glycemic Exposure, Glycemic Control, and Metabolic Karma in Diabetic Complications

Thomas, M. C. (2014) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2014.03.004 · Cited by 43 · see citing works

Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34+ hematopoietic stem cells from diabetic patients

Vinci, M. C., Costantino, S., Damiano, G., Rurali, E., Rinaldi, R., Vigorelli, V., Sforza, A., Carulli, E., Pirola, S., Mastroiacovo, G., et al. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02195-1 · Cited by 45 · see citing works

Can Epigenetics of Endothelial Dysfunction Represent the Key to Precision Medicine in Type 2 Diabetes Mellitus?

Coco, C., Sgarra, L., Potenza, M. A., Nacci, C., Pasculli, B., Barbano, R., Parrella, P., & Montagnani, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122949 · Cited by 41 · see citing works

Hyperglycemic memory in diabetic cardiomyopathy

Zhan, J., Chen, C., Wang, D. W., & Li, H. (2021) · Frontiers of Medicine · doi:10.1007/s11684-021-0881-2 · Cited by 41 · see citing works

Chromatin Modifications Associated with Diabetes

Keating, S. T., & El‐Osta, A. (2012) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-012-9380-9 · Cited by 40 · see citing works

Epigenetics and Cardiovascular Disease in Diabetes

Pasquier, J., Hoarau-Véchot, J., Fakhro, K. A., Rafii, A., & Khalil, C. A. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0677-3 · Cited by 40 · see citing works

Epigenetic Mechanisms of Metabolic Memory in Diabetes

Jayaraman, S. (2012) · Circulation Research · doi:10.1161/circresaha.112.268375 · Cited by 38 · see citing works

Intermittent High Glucose Elevates Nuclear Localization of EZH2 to Cause H3K27me3-Dependent Repression of KLF2 Leading to Endothelial Inflammation

Thakar, S., Katakia, Y. T., Ramakrishnan, S. K., Thakkar, N. P., & Majumder, S. (2021) · Cells · doi:10.3390/cells10102548 · Cited by 36 · see citing works

Quercus infectoria inhibits Set7/NF-κB inflammatory pathway in macrophages exposed to a diabetic environment

Chokpaisarn, J., Urao, N., Voravuthikunchai, S. P., & Koh, T. J. (2017) · Cytokine · doi:10.1016/j.cyto.2017.04.005 · Cited by 36 · see citing works

The vicious cycle between transglutaminase 2 and reactive oxygen species in hyperglycemic memory–induced endothelial dysfunction

Lee, J., Lee, Y., Jeon, H., Han, E., Park, W. S., Hong, S., Kim, Y., & Ha, K. (2019) · The FASEB Journal · doi:10.1096/fj.201901358rr · Cited by 35 · see citing works

The metabolic-epigenetic nexus in type 2 diabetes mellitus

Davison, G. W., Irwin, R. E., & Walsh, C. P. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.025 · Cited by 35 · see citing works

The inflammatory effect of epigenetic factors and modifications in type 2 diabetes

Akbari, M., & Hassan‐Zadeh, V. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00663-9 · Cited by 33 · see citing works

Epigenetic Mechanisms in Vascular Inflammation: Modulation of Endothelial Adhesion Molecules and Endothelium-Leukocyte Adhesion

Calabriso, N., Massaro, M., Scoditti, E., Carluccio, C., Verri, T., & Carluccio, M. A. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2809194 · Cited by 33 · see citing works

Deep sequencing reveals novel Set7 networks

Keating, S. T., Ziemann, M., Okabe, J., Khan, A. W., Balcerczyk, A., & El‐Osta, A. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1651-y · Cited by 32 · see citing works

Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9

Li, G., Li, D., Chun, W., Li, S., Chen, F., Li, P., Ko, C.-N., Wang, W., Lee, S. M., Lin, L., et al. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00804-1 · Cited by 31 · see citing works

Mechanisms of Vascular Inflammation and Potential Therapeutic Targets: A Position Paper From the ESH Working Group on Small Arteries

Rios, F. J. O., Ciuceis, C. D., Georgiopoulos, G. A., Lazaridis, A. A., Nosalski, R., Pavlidis, G., Tual‐Chalot, S., Rosei, C. A., Camargo, L. L., Dąbrowska, E., et al. (2024) · Hypertension · doi:10.1161/hypertensionaha.123.22483 · Cited by 30 · see citing works

SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell

Fujimaki, K., Ogihara, T., Morris, D. L., Oda, H., Iida, H., Fujitani, Y., Mirmira, R. G., Evans‐Molina, C., & Watada, H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.661777 · Cited by 30 · see citing works

Esculetin reverses histone H2A/H2B ubiquitination, H3 dimethylation, acetylation and phosphorylation in preventing type 2 diabetic cardiomyopathy

Kadakol, A., Malek, V., Goru, S. K., Pandey, A., & Gaikwad, A. B. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.05.017 · Cited by 29 · see citing works

Pathophysiology and Prevention of Heart Disease in Diabetes Mellitus

Oktay, A. A., Aktürk, H. K., Esenboğa, K., Javed, F., Polin, N. M., & Jahangir, E. (2017) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2017.05.001 · Cited by 32 · see citing works

Metabolic memory and diabetic nephropathy: Beneficial effects of natural epigenetic modifiers

Kushwaha, K., Sharma, S., & Gupta, J. (2020) · Biochimie · doi:10.1016/j.biochi.2020.01.007 · Cited by 28 · see citing works

Diabetes and Cardiovascular Complications: The Epidemics Continue

López‐Díez, R., Egaña-Gorroño, L., Senatus, L. M., Shekhtman, A. G., Ramasamy, R., & Schmidt, A. M. (2021) · Current Cardiology Reports · doi:10.1007/s11886-021-01504-4 · Cited by 29 · see citing works

Overexpression of lysine-specific demethylase 1 in ovarian endometriomas and its inhibition reduces cellular proliferation, cell cycle progression, and invasiveness

Ding, D., Liu, X., & Guo, S. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.11.033 · Cited by 28 · see citing works

SET8 is involved in the regulation of hyperglycemic memory in human umbilical endothelial cells

Chen, X., Wu, Q., Jiang, H., Wang, J., Zhao, Y., Xu, Y., & Zhu, M. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmy051 · Cited by 27 · see citing works

Mechanisms of Impaired Wound Healing in Type 2 Diabetes: The Role of Epigenetic Factors

Bauer, T. M., Moon, J. Y., Shadiow, J., Buckley, S., & Gallagher, K. A. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.321446 · Cited by 26 · see citing works

The epigenetic landscape in the cardiovascular complications of diabetes

Costantino, S., Ambrosini, S., & Paneni, F. (2018) · Journal of Endocrinological Investigation · doi:10.1007/s40618-018-0956-3 · Cited by 26 · see citing works

Glucose-independent persistence of PAI-1 gene expression and H3K4 tri-methylation in type 1 diabetic mouse endothelium: Implication in metabolic memory

Takizawa, F., Mizutani, S., Ogawa, Y., & Sawada, N. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.02.064 · Cited by 26 · see citing works

Metabolic memory: mechanisms and implications for diabetic vasculopathies

Zhang, E., & Wu, Y. (2014) · Science China Life Sciences · doi:10.1007/s11427-014-4710-6 · Cited by 25 · see citing works

Methyltransferase Set7/9 as a Multifaceted Regulator of ROS Response

Daks, A. A., Shuvalov, O. Y., Fedorova, O., Parfenyev, S. E., Simon, H., & Barlev, N. A. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.83158 · Cited by 24 · see citing works

Set7 mediated interactions regulate transcriptional networks in embryonic stem cells

Tuano, N., Okabe, J., Ziemann, M., Cooper, M. E., & El‐Osta, A. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw621 · Cited by 24 · see citing works

The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response

Daks, A. A., Vasileva, E., Fedorova, O., Shuvalov, O. Y., & Barlev, N. A. (2022) · Life · doi:10.3390/life12030362 · Cited by 24 · see citing works

Histone demethylase KDM1A represses inflammatory gene expression in preadipocytes

Hanzu, F. A., Musri, M. M., Sánchez‐Herrero, A., Claret, M., Esteban, Y., Kaliman, P., Gomis, R., & Párrizas, M. (2013) · Obesity · doi:10.1002/oby.20479 · Cited by 23 · see citing works

Simultaneous inhibition of neprilysin and activation of ACE2 prevented diabetic cardiomyopathy

Malek, V., Sharma, N., & Gaikwad, A. B. (2019) · Pharmacological Reports · doi:10.1016/j.pharep.2019.05.008 · Cited by 22 · see citing works

Sustained kidney biochemical derangement in treated experimental diabetes: a clue to metabolic memory

de Oliveira, A. A. F., de Oliveira, T. F., Bobadilla, L. L., Garcia, C. C. M., Berra, C. M., de Souza-Pinto, N. C., de Medeiros, M. H. G., Mascio, P. D., Zatz, R., & Loureiro, A. P. D. M. (2017) · Scientific Reports · doi:10.1038/srep40544 · Cited by 22 · see citing works

MeCP2 interacts with chromosomal microRNAs in brain

Khan, A. W., Ziemann, M., Rafehi, H., Maxwell, S., Ciccotosto, G. D., & El‐Osta, A. (2017) · Epigenetics · doi:10.1080/15592294.2017.1391429 · Cited by 22 · see citing works

Redox Mediating Epigenetic Changes Confer Metabolic Memories

El‐Osta, A. (2012) · Circulation Research · doi:10.1161/circresaha.112.274936 · Cited by 22 · see citing works

Glycemic memory associated epigenetic changes

Siebel, A. L., Fernández, A. Z., & El‐Osta, A. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.06.005 · Cited by 103 · see citing works

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cellsPreprint

Pirola, L., Balcerczyk, A., Tothill, R. W., Haviv, I., Kaspi, A., Lunke, S., Ziemann, M., Karagiannis, T. C., Tonna, S. J., Kowalczyk, A., et al. (2011) · Genome Research · doi:10.1101/gr.116095.110 · Cited by 220 · see citing works

Hyperglycaemic control of histone code in metabolic inflammation and microvascular complications

Mossel, D. M., Moganti, K., Klüter, H., Harmsen, M. C., & Kzhyshkowska, J. G. (2018) · Diabetologie und Stoffwechsel · doi:10.1055/s-0038-1641807

Adverse Epigenetic Signatures by Histone Methyltransferase Set7 Contribute to Vascular Dysfunction in Patients With Type 2 Diabetes Mellitus

Paneni, F., Costantino, S., Battista, R., Castello, L., Capretti, G., Chiandotto, S., Scavone, G., Villano, A., Pitocco, D., Lanza, G. A., et al. (2014) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.114.000671 · Cited by 176 · see citing works

The human aortic endothelium undergoes dose-dependent DNA methylation in response to transient hyperglycemia

Pepin, M. E., Schiano, C., Miceli, M., Benincasa, G., Mansueto, G., Grimaldi, V., Soricelli, A., Wende, A. R., & Claudio Napoli, A. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112485 · Cited by 42 · see citing works