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Endocrine-Induced Regression of Cancers
Abstract
Cancer is not necessarily autonomous and intrinsically self-perpetuating. Its growth can be sustained and propagated by hormonal function in the host which is not unusual in kind or exaggerated in rate but which is operating at normal or even subnormal levels. Hormones, or synthetic substances inducing physiologic effects similar thereto, are of crucial significance for survival of several kinds of hormone-responsive cancers in man and animals. Opposite sorts of change of the hormonal status can induce regression and, in some instances, cure such cancers. These modifications are deprivation of essential hormones and hormone interference by giving large amounts of critical compounds. The control of cancer by endocrine methods can be described in three propositions: (i) Some types of cancer cells differ in a cardinal way from the cells from which they arose in their response to change in their hormonal environment. (ii) Certain cancers are hormone-dependent and these cells die when supporting hormones are eliminated. (iii) Certain cancers succumb when large amounts of hormones are administered.
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Citations
Cited by
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Hayes, C. L., Spink, D. C., Spink, B. C., Cao, J. Q., Walker, N. J., & Sutter, T. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9776 · Cited by 632
Environmental causes of cancer: endocrine disruptors as carcinogens
Soto, A. M., & Sonnenschein, C. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.87 · Cited by 573
The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis
Pomerantz, M. M., Li, F., Takeda, D. Y., Lenci, R., Chonkar, A., Chabot, M., Cejas, P., Vazquez, F., Cook, J., Shivdasani, R. A., et al. (2015) · Nature Genetics · doi:10.1038/ng.3419 · Cited by 470
Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers
Honda, S., Loher, P., Shigematsu, M., Palazzo, J. P., Suzuki, R., Imoto, I., Rigoutsos, I., & Kirino, Y. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510077112 · Cited by 386
Soto, A. M., & Sonnenschein, C. (2011) · BioEssays · doi:10.1002/bies.201100025 · Cited by 349
Metadata
- Authors
- Huggins, C.
- Venue
- Science
- Published
- 1967-05-26
- Volume
- 156
- Issue
- 3778
- Pages
- 1050-1054
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2025458001
- Cited by
- 235
- References
- 0
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- closed
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