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Cited by 573

The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.

Environmental causes of cancer: endocrine disruptors as carcinogens

Open access
Soto, Ana M., Sonnenschein, Carlos·2010·Nature Reviews Endocrinology
DOI 10.1038/nrendo.2010.87
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Abstract

Environmental endocrine disrupting chemicals (EDCs), including pesticides and industrial chemicals, have been and are released into the environment producing deleterious effects on wildlife and humans. The effects observed in animal models after exposure during organogenesis correlate positively with an increased incidence of malformations of the male genital tract and of neoplasms and with the decreased sperm quality observed in European and US populations. Exposure to EDCs generates additional effects, such as alterations in male and female reproduction and changes in neuroendocrinology, behavior, metabolism and obesity, prostate cancer and thyroid and cardiovascular endocrinology. This Review highlights the carcinogenic properties of EDCs, with a special focus on bisphenol A. However, humans and wildlife are exposed to a mixture of EDCs that act contextually. To explain this mindboggling complexity will require the design of novel experimental approaches that integrate the effects of different doses of structurally different chemicals that act at different ages on different target tissues. The key to this complex problem lies in the adoption of mathematical modeling and computer simulations afforded by system biology approaches. Regardless, the data already amassed highlight the need for a public policy to reduce exposure to EDCs.

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Metadata

Authors
Soto, A. M., & Sonnenschein, C.
Venue
Nature Reviews Endocrinology
Publisher
Springer Science and Business Media LLC
Published
2010-05-25
Volume
6
Issue
7
Pages
363-370
ISSN
  • 1759-5029 (ISSN-L)
  • 1759-5037
DOI
10.1038/nrendo.2010.87
OpenAlex
W2031982698
Cited by
573
References
92
FWCI
6.91
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Environmental causes of cancer: endocrine disruptors as carcinogens. https://app.cochat.ai/papers/10.1038/nrendo.2010.87
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Soto, A. M., & Sonnenschein, C. (2010). Environmental causes of cancer: endocrine disruptors as carcinogens. Nature Reviews Endocrinology. https://doi.org/10.1038/nrendo.2010.87

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.