A Portal Blood Factor as the Humoral Agent in Liver Regeneration
Abstract
It was demonstrated, by use of extracorporeal cross-circulation, that a humoral factor responsible for liver regeneration does not arise from the liver remnant. While intact livers of normal rats incorporated [methyl- 3 H]thymidine in proportion to the amount of liver removed in the partner, the greatest response occurred after a total hepatectomy. Evidence from portacaval-shunted, partially hepatectomized animals connected to normal members indicates that the factor is in portal blood and that the onset of regeneration is the result of a quantitative imbalance between the available portal blood factor and the number of liver cells present.
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In experiments where the portal circulations of two animals are connected via a shunt, hepatectomy in one animal induces liver growth in the other, despite the absence of direct liver tissue damage.
“Moreover, in experiments where the portal circulations of two animals are connected via a shunt, hepatectomy in one animal induces liver growth in the other, despite the absence of direct liver tissue damage[40,41].”
From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [40]
Mitogenic signals for hepatocytes are transported in the blood and induce immediate early genes within 30 minutes after partial hepatectomy.
“Convincing evidence has been found that mitogenic signals for hepatocytes are transported in the blood 2,3 and that they induce a number of immediate early genes within 30 minutes after PH. 4”
From Interleukin 6 Is Important for Survival After Partial Hepatectomy in Mice (2003) · cites this paper as [2]
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Romanova, L. K., & Zhikhareva, I. A. (1972) · Bulletin of Experimental Biology and Medicine · doi:10.1007/bf00796792 · Cited by 11 · see citing works
Stevens, K. R., Schwartz, R. E., Ng, S., Shan, J., & Bhatia, S. N. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-398358-9.00046-x · Cited by 10 · see citing works
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- Authors
- Fisher, B., Szuch, P., Levine, M., & Fisher, E. R.
- Affiliations
- University of Pittsburgh (US)
- ORCID
- Fisher, Bernard
- Venue
- Science
- Published
- 1971-02-12
- Volume
- 171
- Issue
- 3971
- Pages
- 575-577
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2038241495
- Cited by
- 161
- References
- 7
- Citations by year
- 2025: 1 · 2023: 1 · 2020: 2 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 3
- FWCI
- 15.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- liver regeneration, humoral factors, portal blood, partial hepatectomy, portacaval shunt, thymidine incorporation, remnant liver
- MeSH terms
- Animals, Blood, DNA, Female, Hepatectomy, Liver, Liver Circulation, Liver Regeneration, Parabiosis, Portacaval Shunt, Surgical, Thymidine, Tritium, Rats
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