The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
The Roles of the Subunits in the Function of the Calcium Channel
Open accessAbstract
Dihydropyridine-sensitive voltage-dependent L-type calcium channels are critical to excitation-secretion and excitation-contraction coupling. The channel molecule is a complex of the main, pore-forming subunit α 1 and four additional subunits: α 2 , δ, β, and γ (α 2 and δ are encoded by a single messenger RNA). The α 1 subunit messenger RNA alone directs expression of functional calcium channels in Xenopus oocytes, and coexpression of the α 2 /δ and β subunits enhances the amplitude of the current. The α 2 , δ, and γ subunits also have pronounced effects on its macroscopic characteristics, such as kinetics, voltage dependence of activation and inactivation, and enhancement by a dihydropyridine agonist. In some cases, specific modulatory functions can be assigned to individual subunits, whereas in other cases the different subunits appear to act in concert to modulate the properties of the channel.
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Hodgkin, A. L., & Huxley, A. F. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004764 · Cited by 23,191
Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation
Hoshi, T., Zagotta, W. N., & Aldrich, R. W. (1990) · Science · doi:10.1126/science.2122519 · Cited by 1,538
Primary structure of the receptor for calcium channel blockers from skeletal muscle
Tanabe, T., Takeshima, H., Mikami, A., Flockerzi, V., Takahashi, H., Kangawa, K., Kojima, M., Matsuo, H., Hirose, T., & Numa, S. (1987) · Nature · doi:10.1038/328313a0 · Cited by 1,371
Self-citationStructural parts involved in activation and inactivation of the sodium channel
Stühmer, W., Conti, F., Suzuki, H., Wang, X., Noda, M., Yahagi, N., Kubo, H., & Numa, S. (1989) · Nature · doi:10.1038/339597a0 · Cited by 1,215
Structure and Function of Voltage-Sensitive Ion Channels
Catterall, W. A. (1988) · Science · doi:10.1126/science.2459775 · Cited by 1,174
Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel
Mikami, A., Imoto, K., Tanabe, T., Niidome, T., Mori, Y., Takeshima, H., Narumiya, S., & Numa, S. (1989) · Nature · doi:10.1038/340230a0 · Cited by 920
Primary structure and functional expression from complementary DNA of a brain calcium channel
Mori, Y., Friedrich, T., Kim, M.-S., Mikami, A., Nakai, J., Ruth, P., Bosse, E., Hofmann, F., Flockerzi, V., Furuichi, T., et al. (1991) · Nature · doi:10.1038/350398a0 · Cited by 866
Self-citationRegions of the skeletal muscle dihydropyridine receptor critical for excitation–contraction coupling
Tanabe, T., Beam, K. G., Adams, B. A., Niidome, T., & Numa, S. (1990) · Nature · doi:10.1038/346567a0 · Cited by 607
Ellis, S. B., Williams, M. E., Ways, N. R., Brenner, R., Sharp, A. H., Leung, A. T., Campbell, K. P., McKenna, E., Koch, W. J., Hui, A., et al. (1988) · Science · doi:10.1126/science.2458626 · Cited by 571
Lee, K. S., Marban, E., & Tsien, R. W. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015752 · Cited by 478
Cited by
Structure and Regulation of Voltage-Gated Ca 2+ Channels
Catterall, W. A. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.521 · Cited by 2,344
Voltage-Gated Calcium Channels
Catterall, W. A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003947 · Cited by 1,628
Calcium Absorption Across Epithelia
Hoenderop, J. G. J., Nilius, B., & Bindels, R. J. M. (2005) · Physiological Reviews · doi:10.1152/physrev.00003.2004 · Cited by 936
Exocytotic Ca2+ channels in mammalian central neurons
Dunlap, K., Luebke, J. I., & Turner, T. J. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)80030-6 · Cited by 915
P-type calcium channels in rat central and peripheral neurons
Mintz, I. M., Adams, M. E., & Bean, B. P. (1992) · Neuron · doi:10.1016/0896-6273(92)90223-z · Cited by 786
Metadata
- Authors
- Singer, D., Biel, M., Lotan, I., Flockerzi, V., Hofmann, F., & Dascal, N.
- Venue
- Science
- Published
- 1991-09-27
- Volume
- 253
- Issue
- 5027
- Pages
- 1553-1557
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999503127
- Cited by
- 553
- References
- 28
- FWCI
- 12.81
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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