The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The α Subunit of the GTP Binding Protein G k Opens Atrial Potassium Channels
Abstract
Guanine nucleotide binding (G) proteins (subunit composition αβγ) dissociate on activation with guanosine triphosphate (GTP) analogs and magnesium to give α-guanine nucleotide complexes and free βγ subunits. Whether the opening of potassium channels by the recently described G k in isolated membrane patches from mammalian atrial myocytes was mediated by the α k subunit or βγ dimer was tested. The α k subunit was found to be active, while the βγ dimer was inactive in stimulating potassium channel activity. Thus, G k resembles G s , the stimulatory regulatory component of adenylyl cyclase, and transducin, the regulatory component of the visual system, in that it regulates its effector function—the activity of the ligand-gated potassium channel—through its guanine nucleotide binding subunit.
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Cites
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Cited by
Receptor-effector coupling by G proteins
Birnbaumer, L., Abramowitz, J., & Brown, A. M. (1990) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(90)90007-y · Cited by 1,118
Self-citationRegulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G q
Smrcka, A. V., Hepler, J. R., Brown, K. O., & Sternweis, P. C. (1991) · Science · doi:10.1126/science.1846707 · Cited by 894
Alpha‐2 and imidazoline receptor agonistsTheir pharmacology and therapeutic role
Khan, Z. P., Ferguson, C. N., & Jones, R. M. (1999) · Anaesthesia · doi:10.1046/j.1365-2044.1999.00659.x · Cited by 686
Mu and delta receptors belong to a family of receptors that are coupled to potassium channels.
North, R. A., Williams, J. T., Surprenant, A., & Christie, M. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.15.5487 · Cited by 618
Lüscher, C., & Slesinger, P. A. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2834 · Cited by 617
Metadata
- Authors
- Codina, J., Yatani, A., Grenet, D., Brown, A. M., & Birnbaumer, L.
- Venue
- Science
- Published
- 1987-04-24
- Volume
- 236
- Issue
- 4800
- Pages
- 442-445
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2010491659
- Cited by
- 312
- References
- 1
- FWCI
- 20.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Codina, J., Yatani, A., Grenet, D., Brown, A. M., & Birnbaumer, L. (1987). The α Subunit of the GTP Binding Protein G k Opens Atrial Potassium Channels. Science. https://doi.org/10.1126/science.2436299
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
