The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Cloning of Complementary DNA for GAP-43, a Neuronal Growth-Related Protein
Abstract
GAP-43 is one of a small subset of cellular proteins selectively transported by a neuron to its terminals. Its enrichment in growth cones and its increased levels in developing or regenerating neurons suggest that it has an important role in neurite growth. A complementary DNA (cDNA) that encodes rat GAP-43 has been isolated to study its structural characteristics and regulation. The predicted molecular size is 24 kilodaltons, although its migration in SDS-polyacrylamide gels is anomalously retarded. Expression of GAP-43 is limited to the nervous system, where its levels are highest during periods of neurite outgrowth. Nerve growth factor or adenosine 3′,5′-monophosphate induction of neurites from PC12 cells is accompanied by increased GAP-43 expression. GAP-43 RNA is easily detectable, although at diminished levels, in the adult rat nervous system. This regulation of GAP-43 is concordant with a role in growth-related processes of the neuron, processes that may continue in the mature animal.
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Cites
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Electrical stimulation promotes sensory neuron regeneration and growth-associated gene expression
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Metadata
- Authors
- Karns, L. R., Ng, S.-C., Freeman, J. A., & Fishman, M. C.
- Venue
- Science
- Published
- 1987-05
- Volume
- 236
- Issue
- 4801
- Pages
- 597-600
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1992785510
- Cited by
- 349
- References
- 23
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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