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Osteoclastic Bone Resorption by a Polarized Vacuolar Proton Pump
Abstract
Bone resorption depends on the formation, by osteoclasts, of an acidic extracellular compartment wherein matrix is degraded. The mechanism by which osteoclasts transport protons into that resorptive microenvironment was identified by means of adenosine triphosphate-dependent weak base accumulation in isolated osteoclast membrane vesicles, which exhibited substrate and inhibition properties characteristic of the vacuolar, electrogenic H + -transporting adenosine triphosphatase (H + -ATPase). Identify of the proton pump was confirmed by immunoblot of osteoclast membrane proteins probed with antibody to vacuolar H + -ATPase isolated from bovine kidney. The osteoclast's H + -ATPase was immunocytochemically localized to the cell-bone attachment site. Immunoelectron microscopy showed that the H + -ATPase was present in the ruffled membrane, the resorptive organ of the cell.
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Citations
Cited by
Bone Resorption by Osteoclasts
Teitelbaum, S. L. (2000) · Science · doi:10.1126/science.289.5484.1504 · Cited by 3,962
Self-citationRoodman, G. D. (2004) · New England Journal of Medicine · doi:10.1056/nejmra030831 · Cited by 2,755
Loss of the ClC-7 Chloride Channel Leads to Osteopetrosis in Mice and Man
Kornak, U., Kasper, D., Bösl, M. R., Kaiser, E., Schweizer, M., Schulz, A., Friedrich, W., Delling, G., & Jentsch, T. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00206-9 · Cited by 995
Sato, M., Grasser, W., Endo, N., Akins, R., Simmons, H., Thompson, D. D., Golub, E., & Rodan, G. A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115539 · Cited by 1,004
Osteoclasts: What Do They Do and How Do They Do It?
Teitelbaum, S. L. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.060834 · Cited by 730
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Metadata
- Authors
- Blair, H. C., Teitelbaum, S. L., Ghiselli, R., & Gluck, S.
- Venue
- Science
- Published
- 1989-08-25
- Volume
- 245
- Issue
- 4920
- Pages
- 855-857
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999826236
- Cited by
- 860
- References
- 0
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Blair, H. C., Teitelbaum, S. L., Ghiselli, R., & Gluck, S. (1989). Osteoclastic Bone Resorption by a Polarized Vacuolar Proton Pump. Science. https://doi.org/10.1126/science.2528207
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