The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Inhibition of Antigen-Induced Lymphocyte Proliferation by Tat Protein from HIV-1
Abstract
The purified human immunodeficiency virus type-1 (HIV-1) Tat protein inhibited lymphocyte proliferation induced by tetanus toxoid or Candida antigens by 66 to 97% at nanomolar concentrations of Tat. In contrast, Tat did not cause a significant reduction of lymphocyte proliferation in response to mitogens such as phytohemagglutinin or pokeweed mitogen. Inhibition was blocked by oxidation of the cysteine-rich region of Tat or by incubation with an antibody to Tat before the assay. A synthetic Tat peptide (residues 1 to 58) also inhibited antigen-stimulated proliferation. Experiments with H9 and U937 cell lines showed that Tat can easily enter both lymphocytes and monocytes. The specific inhibition of antigen-induced lymphocyte proliferation by Tat mimics the effect seen with lymphocytes from HIV-infected individuals and suggests that Tat might directly contribute to the immunosuppression associated with HIV infection.
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Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B
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Induction of Apoptosis in Uninfected Lymphocytes by HIV-1 Tat Protein
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Metadata
- Authors
- Viscidi, R. P., Mayur, K., Lederman, H. M., & Frankel, A. D.
- Venue
- Science
- Published
- 1989-12-22
- Volume
- 246
- Issue
- 4937
- Pages
- 1606-1608
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2064914230
- Cited by
- 329
- References
- 16
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Viscidi, R. P., Mayur, K., Lederman, H. M., & Frankel, A. D. (1989). Inhibition of Antigen-Induced Lymphocyte Proliferation by Tat Protein from HIV-1. Science. https://doi.org/10.1126/science.2556795
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
