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The Role of the T3/Antigen Receptor Complex in T-Cell Activation
Abstract
The role of the T3/antigen receptor complex is summarized by the diagram presented in Figure 4. Signals transmitted through T3/Ti activate a phosphodiesterase. This enzyme acts on its substrate PIP2 to generate two important mediators, IP3 and diacylglycerol. IP3 mobilizes calcium from bound intracellular stones. This increase in [Ca2+]i is one intracellular signal which, in conjunction with others, induces expression of lymphokine genes by influencing pretranslational, presumably transcriptional, events. Several problems remain. Which of the five molecules in the T3/Ti complex serves as the effector molecule in the transmembrane signaling process is not known. Which molecules serve to link T3/Ti to the phosphodiesterase enzyme is under investigation. The role diacylglycerol protein kinase C and other mediators play in signalling activation is not established. Finally, for those events occurring after the early events pictured in Figure 4 that result in gene activation, the sequence is a black box. Approaches to address each of these questions are available, and answers should be forthcoming.
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Citations
Cites
T cell antigen receptors and the immunoglobulin supergene family
Hood, L. (1985) · Cell · doi:10.1016/0092-8674(85)90133-3 · Cited by 433
Transcriptional Enhancer Elements in the Mouse Immunoglobulin Heavy Chain Locus
Mercola, M., Wang, X.-F., Olsen, J., & Calame, K. (1983) · Science · doi:10.1126/science.6306772 · Cited by 152
Cited by
A cell culture model for T lymphocyte clonal anergy
Schwartz, R. H. (1990) · Science · doi:10.1126/science.2113314 · Cited by 1,857
Schwartz, R. H. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141110 · Cited by 1,487
Treatment of Murine Lupus with CTLA4Ig
Finck, B. K., Linsley, P. S., & Wofsy, D. (1994) · Science · doi:10.1126/science.7520604 · Cited by 668
Diehn, M., Alizadeh, A. A., Rando, O. J., Liu, C. L., Stankunas, K., Botstein, D., Crabtree, G. R., & Brown, P. O. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092284399 · Cited by 337
Glaser, R. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810200015002 · Cited by 163
Metadata
- Authors
- Weiss, A.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1986-01-01
- Volume
- 4
- Issue
- 1
- Pages
- 593-619
- ISSN
- 0732-0582 (ISSN-L)
- OpenAlex
- W2173828780
- Cited by
- 619
- References
- 2
- FWCI
- 34.04
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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