The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
High-Resolution Microcoil 1 H-NMR for Mass-Limited, Nanoliter-Volume Samples
Abstract
High-resolution, proton nuclear magnetic resonance (NMR) spectra of 5-nanoliter samples have been obtained with much higher mass sensitivity [signal-to-noise ratio (S/N) per micromole] than with traditional methods. Arginine and sucrose show a mean sensitivity enhancement of 130 compared to 278-microliter samples run in a 5-millimeter tube in a conventional, commercial probe. This can reduce data acquisition time by a factor of >16,000 or reduce the needed sample mass by a factor of about 130. A linewidth of 0.6 hertz was achieved on a 300-megahertz spectrometer by matching the magnetic susceptibility of the medium that surrounds the detection cell to that of the copper coil. For sucrose, the limit of detection (defined at S/N = 3) was 19 nanograms (56 picomoles) for a 1-minute data acquisition. This technique should prove useful with mass-limited samples and for use as a detector in capillary separations.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The signal-to-noise ratio of the nuclear magnetic resonance experiment
Hoult, D. I., & Richards, R. E. (1976) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(76)90233-x · Cited by 1,132
The signal-to-noise ratio of the nuclear magnetic resonance experiment
Hoult, D. I., & Richards, R. E. (2011) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2011.09.018 · Cited by 995
The sensitivity of the zeugmatographic experiment involving human samples
Hoult, D. I., & Lauterbur, P. C. (1979) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(79)90019-2 · Cited by 776
Vorm, O., Roepstorff, P., & Mann, M. (1994) · Analytical Chemistry · doi:10.1021/ac00091a044 · Cited by 687
Magnetic resonance force microscopy
Sidles, J. A., Garbini, J. L., Bruland, K. J., Rugar, D., Züger, O., Hoen, S., & Yannoni, C. S. (1995) · Reviews of Modern Physics · doi:10.1103/revmodphys.67.249 · Cited by 466
Design and Analysis of Microcoils for NMR Microscopy
Peck, T. L., Magin, R. L., & Lauterbur, P. C. (1995) · Journal of Magnetic Resonance Series B · doi:10.1006/jmrb.1995.1112 · Cited by 283
Self-citationA High-Temperature Superconducting Receiver for Nuclear Magnetic Resonance Microscopy
Black, R. D., Early, T. A., Roemer, P. B., Mueller, O. M., Mogro-Campero, A., Turner, L. G., & Johnson, G. A. (1993) · Science · doi:10.1126/science.8430331 · Cited by 206
Performance of a High-Temperature Superconducting Resonator for High-Field Imaging
Black, R. D., Early, T. A., & Johnson, G. A. (1995) · Journal of Magnetic Resonance Series A · doi:10.1006/jmra.1995.1058 · Cited by 43
Cited by
Chip–NMR biosensor for detection and molecular analysis of cells
Lee, H., Sun, E., Ham, D., & Weissleder, R. (2008) · Nature Medicine · doi:10.1038/nm.1711 · Cited by 621
Advances in metabolite identification
Wishart, D. S. (2011) · Bioanalysis · doi:10.4155/bio.11.155 · Cited by 284
Metadata
- Authors
- Olson, D. L., Peck, T. L., Webb, A. G., Magin, R. L., & Sweedler, J. V.
- Venue
- Science
- Published
- 1995-12-22
- Volume
- 270
- Issue
- 5244
- Pages
- 1967-1970
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2034223990
- Cited by
- 503
- References
- 8
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: High-Resolution Microcoil 1 H-NMR for Mass-Limited, Nanoliter-Volume Samples. https://app.cochat.ai/papers/10.1126/science.270.5244.1967
- The paper
- Olson, D. L., Peck, T. L., Webb, A. G., Magin, R. L., & Sweedler, J. V. (1995). High-Resolution Microcoil 1 H-NMR for Mass-Limited, Nanoliter-Volume Samples. Science. https://doi.org/10.1126/science.270.5244.1967
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
