The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Interfering with Apoptosis: Ca 2+ -Binding Protein ALG-2 and Alzheimer's Disease Gene ALG-3
Abstract
Two apoptosis-linked genes, named ALG-2 and ALG-3 , were identified by means of a functional selection strategy. ALG-2 codes for a Ca 2+ -binding protein required for T cell receptor-, Fas-, and glucocorticoid-induced cell death. ALG-3 , a partial complementary DNA that is homologous to the familial Alzheimer's disease gene STM2 , rescues a T cell hybridoma from T cell receptor- and Fas-induced apoptosis. These findings suggest that ALG-2 may mediate Ca 2+ -regulated signals along the death pathway and that cell death may play a role in Alzheimer's disease.
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Cites
Apoptosis in the Pathogenesis and Treatment of Disease
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Candidate gene for the chromosome 1 familial Alzheimer’s disease locus
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The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice
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Cited by
Apoptosis in neurodegenerative disorders
Mattson, M. P. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35040009 · Cited by 1,605
Skeletal and CNS Defects in Presenilin-1-Deficient Mice
Shen, J., Bronson, R. T., Chen, D. F., Xia, W., Selkoe, D. J., & Tonegawa, S. (1997) · Cell · doi:10.1016/s0092-8674(00)80244-5 · Cited by 959
Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling
De Smaele, E., Zazzeroni, F., Papa, S., Nguyen, D. U., Jin, R., Jones, J., Cong, R., & Franzoso, G. (2001) · Nature · doi:10.1038/35104560 · Cited by 732
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Metadata
- Authors
- Vito, P., Lacaná, E., & D'Adamio, L.
- Venue
- Science
- Published
- 1996-01-26
- Volume
- 271
- Issue
- 5248
- Pages
- 521-525
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1981845572
- Cited by
- 468
- References
- 5
- FWCI
- 20.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Interfering with Apoptosis: Ca 2+ -Binding Protein ALG-2 and Alzheimer's Disease Gene ALG-3. https://app.cochat.ai/papers/10.1126/science.271.5248.521
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- Vito, P., Lacaná, E., & D'Adamio, L. (1996). Interfering with Apoptosis: Ca 2+ -Binding Protein ALG-2 and Alzheimer's Disease Gene ALG-3. Science. https://doi.org/10.1126/science.271.5248.521
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
