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Identification of a Committed Precursor for the Mast Cell Lineage

Rodewald, Hans-Reimer, Dessing, Mark, Dvorak, Ann M., Galli, Stephen J.·1996·Science
DOI 10.1126/science.271.5250.818
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Abstract

Mast cells originate from hematopoietic stem cells, but the mast cell-committed precursor has not been identified. In the study presented here, a cell population in murine fetal blood that fulfills the criteria of progenitor mastocytes was identified. It is defined by the phenotype Thy-1 lo c-Kit hi , contains cytoplasmic granules, and expresses RNAs encoding mast cell-associated proteases but lacks expression of the high-affinity immunoglobulin E receptor. Thy-1 lo c-Kit hi cells generated functionally competent mast cells at high frequencies in vitro but lacked developmental potential for other hematopoietic lineages. When transferred intraperitoneally, this population reconstituted the peritoneal mast cell compartment of genetically mast cell-deficient W / W v mice to wild-type levels.

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Metadata

Authors
Rodewald, H.-R., Dessing, M., Dvorak, A. M., & Galli, S. J.
Affiliations
  • H.-R. Rodewald and M. Dessing, Basel Institute for Immunology, Grenzacherstrasse 487, CH-4005 Basel, Switzerland.
  • A. M. Dvorak and S. J. Galli, Department of Pathology, Beth Israel Hospital, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1996-02-09
Volume
271
Issue
5250
Pages
818-822
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.271.5250.818
Cited by
285
References
0
Language
en

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