Cited by 209Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

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Bidirectional Control of Quantal Size by Synaptic Activity in the Hippocampus

Oliet, Stéphane H. R., Malenka, Robert C., Nicoll, Roger A.·1996·Science

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Abstract

Analysis of strontium-induced asynchronous release of quanta from stimulated synapses revealed that long-term potentiation and long-term depression in the CA1 region of the mammalian hippocampus are associated with an increase and a decrease, respectively, in quantal size. At a single set of synapses, the increase in quantal size seen with long-term potentiation was completely reversed by depotentiating stimuli. Long-term potentiation and depression are also associated with an increase and decrease, respectively, in the frequency of quantal events, consistent with an all-or-none regulation (up or down) of clusters of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, a change in the release of transmitter, or both.

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Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice
Liao, D., Hessler, N. A., & Malinow, R. (1995) · Nature · doi:10.1038/375400a0 · Cited by 1,365
Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents
Manabe, T., Renner, P., & Nicoll, R. A. (1992) · Nature · doi:10.1038/355050a0 · Cited by 366
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ASZTELY F, SYNAPTIC POTENTIATION IN THE HIPPOCAMPAL CA1 REGION INDUCED BY APPLICATION OF N-METHYL-D-ASPARTATE, BRAIN RESEARCH 558, 153 (1991). · DOI
BAIN I. A., QUANTAL TRANSMITTER RELEASE MEDIATED BY STRONTIUM AT THE MOUSE MOTOR-NERVE TERMINAL, JOURNAL OF PHYSIOLOGY-LONDON 450, 63 (1992). · DOI
BEKKERS M. J., QUANTAL ANALYSIS OF EPSCS RECORDED FROM SMALL NUMBERS OF SYNAPSES IN HIPPOCAMPAL CULTURES, JOURNAL OF NEUROPHYSIOLOGY 73, 1145 (1995). · DOI
BLANTON G. M., WHOLE CELL RECORDING FROM NEURONS IN SLICES OF REPTILIAN AND MAMMALIAN CEREBRAL-CORTEX, JOURNAL OF NEUROSCIENCE METHODS 30, 203 (1989). · DOI
BLISS TVP, A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS, NATURE 361, 31 (1993). · DOI · Paper page
10.1126/science.7909958 · DOI
10.1126/science.7569903 · DOI
DELCASTILLO J, QUANTAL COMPONENTS OF THE END-PLATE POTENTIAL, JOURNAL OF PHYSIOLOGY-LONDON 124, 560 (1954). · DOI
DODGE A. F., STRONTIUM AND QUANTAL RELEASE OF TRANSMITTER AT NEUROMUSCULAR JUNCTION, JOURNAL OF PHYSIOLOGY-LONDON 200, 267 (1969). · DOI
EDWARDS F, NEUROBIOLOGY - LTP IS A LONG-TERM PROBLEM, NATURE 350, 271 (1991). · DOI · Paper page
GODA Y, 2 COMPONENTS OF TRANSMITTER RELEASE AT A CENTRAL SYNAPSE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91, 12942 (1994). · DOI
GROVER M. L., DIFFERENT MECHANISMS MAY BE REQUIRED FOR MAINTENANCE OF NIMDA RECEPTOR-DEPENDENT AND INDEPENDENT FORMS OF LONG-TERM POTENTIATION, SYNAPSE 19, 121 (1995). · DOI
HANSE E, TEA ELICITS 2 DISTINCT POTENTIATIONS OF SYNAPTIC TRANSMISSION IN THE CA1 REGION OF THE HIPPOCAMPAL SLICE, JOURNAL OF NEUROSCIENCE 14, 5028 (1994). · DOI · Paper page
HUBER M. K., DISTINCT LTP INDUCTION MECHANISMS - CONTRIBUTION OF NMDA RECEPTORS AND VOLTAGE-DEPENDENT CALCIUM CHANNELS, JOURNAL OF NEUROPHYSIOLOGY 73, 270 (1995). · DOI
ISAAC JTR, EVIDENCE FOR SILENT SYNAPSES - IMPLICATIONS FOR THE EXPRESSION OF LTP, NEURON 15, 427 (1995). · DOI · Paper page
KATZ B, NERVE MUSCLE SYNAPSE (1966).
KULLMANN M. D., LONG-TERM POTENTIATION IS ASSOCIATED WITH INCREASES IN QUANTAL CONTENT AND QUANTAL AMPLITUDE, NATURE 357, 240 (1992). · DOI
KULLMANN M. D., CA2+ ENTRY VIA POSTSYNAPTIC VOLTAGE-SENSITIVE CA2+ CHANNELS CAN TRANSIENTLY POTENTIATE EXCITATORY SYNAPTIC TRANSMISSION IN THE HIPPOCAMPUS, NEURON 9, 1175 (1992). · DOI · Paper page
LARKMAN A, PRESYNAPTIC RELEASE PROBABILITY INFLUENCES THE LOCUS OF LONG-TERM POTENTIATION, NATURE 360, 70 (1992). · DOI
LARKMAN U. A., SYNAPTIC PLASTICITY - HIPPOCAMPAL LTP, CURRENT OPINION IN NEUROBIOLOGY 5, 324 (1995). · DOI
LIAO D, DIRECT MEASUREMENT OF QUANTAL CHANGES UNDERLYING LONG-TERM POTENTIATION IN CA1 HIPPOCAMPUS, NEURON 9, 1089 (1992). · DOI
MALGAROLI A, GLUTAMATE-INDUCED LONG-TERM POTENTIATION OF THE FREQUENCY OF MINIATURE SYNAPTIC CURRENTS IN CULTURED HIPPOCAMPAL-NEURONS, NATURE 357, 134 (1992). · DOI
MALINOW R, PRESYNAPTIC ENHANCEMENT SHOWN BY WHOLE-CELL RECORDINGS OF LONG-TERM POTENTIATION IN HIPPOCAMPAL SLICES, NATURE 346, 177 (1990). · DOI
10.1126/science.7916483 · DOI · Paper page
MEIRI U, ACTIVATION OF TRANSMITTER RELEASE BY STRONTIUM AND CALCIUM IONS AT NEUROMUSCULAR JUNCTION, JOURNAL OF PHYSIOLOGY-LONDON 215, 709 (1971). · DOI
MILEDI R, STONTIUM AS A SUBSTITUTE FOR CALCIUM IN PROCESS OF TRANSMITTER RELEASE AT NEUROMUSCULAR JUNCTION, NATURE 212, 1233 (1966). · DOI
MULKEY M. R., MECHANISMS UNDERLYING INDUCTION OF HOMOSYNAPTIC LONG-TERM DEPRESSION IN AREA CA1 OF THE HIPPOCAMPUS, NEURON 9, 967 (1992). · DOI · Paper page
NICOLL A. R., CONTRASTING PROPERTIES OF 2 FORMS OF LONG-TERM POTENTIATION IN THE HIPPOCAMPUS, NATURE 377, 115 (1995). · DOI
REDMAN S, QUANTAL ANALYSIS OF SYNAPTIC POTENTIALS IN NEURONS OF THE CENTRAL NERVOUS-SYSTEM, PHYSIOLOGICAL REVIEWS 70, 165 (1990). · DOI
STEVENS F. C., CHANGES IN RELIABILITY OF SYNAPTIC FUNCTION AS A MECHANISM FOR PLASTICITY, NATURE 371, 704 (1994). · DOI
WYLLIE DJA, A ROLE FOR PROTEIN-KINASES AND PHOSPHATASES IN THE CA2+-INDUCED ENHANCEMENT OF HIPPOCAMPAL AMPA RECEPTOR-MEDIATED SYNAPTIC RESPONSES, NEURON 13, 635 (1994). · DOI · Paper page
ZENGEL E. J., DIFFERENTIAL-EFFECTS OF BA2+, SR2+, AND CA2+ ON STIMULATION-INDUCED CHANGES IN TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR-JUNCTION, JOURNAL OF GENERAL PHYSIOLOGY 76, 175 (1980). · DOI

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“J. 60: 1288–1294, kers and Stevens 1990; Manabe et al. 1993; Oliet et al. 1994; 1991.”
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Method
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BackgroundMethodInfluential
Major impairments of glutamatergic transmission and long-term synaptic plasticity in the hippocampus of mice lacking the melanin-concentrating hormone receptor-1.
Pachoud, B., Adamantidis, A., Ravassard, P., Luppi, P., Grisar, T., Lakaye, B., & Salin, P. (2010) · Journal of Neurophysiology · doi:10.1152/jn.01052.2009 · Cited by 15
The subiculum to entorhinal cortex projection is capable of sustaining both short- and long-term plastic changes.
Craig, S., & Commins, S. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.032 · Cited by 15
Toward a Biophysically Plausible Bidirectional Hebbian Rule
Grzywacz, N., & Burgi, P.-Y. (1998) · Neural Computation · doi:10.1162/089976698300017629 · Cited by 15
“The equations’ initial conditions were wj = w0/2 (the middle of wj’s range) and Es,j = Es,0k3/(k2 + k3), (the steady-state value of Es,j in the absence of inputs).”
Background
Prolonged depolarization of rat cerebral synaptosomes leads to an increase in vesicular glutamate content.
Bole, D., Hirata, K., & Ueda, T. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00105-2 · Cited by 14
Non-canonical role for Lpar1-EGFP subplate neurons in early postnatal mouse somatosensory cortex
Ghezzi, F., Marques-Smith, A., Anastasiades, P. G., Lyngholm, D., Vagnoni, C., Rowett, A., Parameswaran, G., Hoerder-Suabedissen, A., Nakagawa, Y., Molnár, Z., et al. (2021) · eLife · doi:10.7554/elife.60810 · Cited by 13
“Incubation with ACSF containing Sr (Sr-ACSF) leads to asynchronous vesicular release at the presynaptic terminal providing a reasonable estimate of quantal size (Oliet et al., 1996; Gil et al., 1999).”
Background
Template-free solution approach to synthesize ZnSe hollow microspheres
Wang, X.-F., Chen, X.-L., Zheng, H., Jin, J.-Y., & Zhang, Z. (2005) · doi:10.1007/s00339-004-3046-7 · Cited by 13
Analytical approaches to examine gamma-aminobutyric acid and glutamate vesicular co-packaging
Kim, S., & Sabatini, B. L. (2023) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.1076616 · Cited by 10
“Substitution of strontium for calcium is often used to desynchronize release of vesicles from an electrically- or optogenetically-stimulated axons, allowing the study of single vesicle evoked responses (Oliet et al., 1996; Bekkers and Clements, 1999; Lamotte d’Incamps et al., 2017).”
Background
Long-term depression with a flash
Malenka, R., & Nicoll, R. (1998) · Nature Neuroscience · doi:10.1038/333 · Cited by 10
Self-citation
Quantal analysis and long-term potentiation
Korn, H., & Faber, D. S. (1998) · Comptes Rendus de l Académie des Sciences - Series III - Sciences de la Vie · doi:10.1016/s0764-4469(97)89811-3 · Cited by 10
Whisker experience‐dependent mGluR signaling maintains synaptic strength in the mouse adolescent cortex
Kubota, J., Mikami, Y., Kanemaru, K., Sekiya, H., Okubo, Y., & Iino, M. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13285 · Cited by 8
“Quantal size variations of asynchronous EPSCs in the presence of Sr (Goda & Stevens, 1994; Oliet et al., 1996) at L4–L2/3 synapses were distributed identically in deprived and sham-deprived mice [Sham, 336 events”
BackgroundInfluential
Convolution of mini distributions for fitting evoked synaptic amplitude histograms
Bekkers, J. M. (2003) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2003.09.018 · Cited by 9
Stable Properties of Spontaneous EPSCs and Miniature Retinal EPSCs during the Development of ON/OFF Sublamination in the Ferret Lateral Geniculate Nucleus
Hohnke, C. D., & Sur, M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00236.1999 · Cited by 9
“To examine the retinal synapses specifically, we evoked asynchronous transmitter release by stimulating the optic tract after replacing extracellular calcium with strontium (Miledi, 1966; Goda and Stevens, 1994; Abdul-Ghani et al., 1996; Oliet et al., 1996; Choi and Lovinger., 1997; Morishita and Alger, 1997).”
BackgroundResultInfluential
Critical and complex role of N-methyl-d-aspartate receptors in long-term depression at CA3–CA1 synapses in the developing hippocampus
Strandberg, J., & Gustafsson, B. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.081 · Cited by 6
Analysis and Implications of Equivalent Uniform Approximations of Nonuniform Unitary Synaptic Systems
Uteshev, V. V., Patlak, J. B., & Pennefather, P. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76521-0 · Cited by 8
“spontaneous or asynchronously released uni-quantal events and evoked synchronously released events are identical and are released from the same pool (Raastad et al., 1992; Oliet et al., 1996; Liu and Tsien, 1995a,b; Callister and Walmsley, 1996; Taschenberger et al., 1995; Rosenmund and Stevens, 1996).”
Background
Parsing Spontaneous and Evoked Neurotransmission on Both Sides of the Synapse
Rothwell, P. E. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1177-10.2010 · Cited by 5
“Measurement of quantal events in the presence of strontium has the added advantage of restricting release to a defined population of stimulated synapses (Oliet et al., 1996).”
LTD – Synaptic Depression and Memory Storage
Hansel, C., & Bear, M. F. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00017-6 · Cited by 6
Neural Analysis of Learning in Simple Systems
Krasne, F. (2002) · Wiley eBooks · doi:10.1002/0471214426.pas0304 · Cited by 8
AMPA receptor attrition in long-term depression.
Kullmann, D. (1999) · Neuron · doi:10.1016/s0896-6273(00)80841-7 · Cited by 7
“, respectively) (Oliet et al., 1996).”
Ablation of C-fibers decreases quantal size of GABAergic synaptic transmission in the insular cortex
Murayama, S., Yamamoto, K., Kaneko, M., Ogiso, B., & Kobayashi, M. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.09.052 · Cited by 6
β-Amyloid(1–42) induces a reduction in the parallel fiber responses of Purkinje cells: Possible involvement of pro-inflammatory processes
Arbez, N., Gautheron, V., Brugg, B., Mariani, J., & Rovira, C. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.05.007 · Cited by 5
Cell type–specific plasticity in synaptic, intrinsic, and sound response properties of deep-layer cortical neurons after noise trauma
Zhao, Y., Kouvaros, S., Schneider, N. A., Krall, R. F., Lam, S., Arnold, M. P., Williamson, R. S., & Tzounopoulos, T. (2025) · Science Advances · doi:10.1126/sciadv.adx9737 · Cited by 4
Acute stress causes sex-specific changes to ventral subiculum synapses, circuitry, and anxiety-like behavior
Miller, C. N., Li, Y., Beier, K. T., & Aoto, J. N. (2025) · Nature Communications · doi:10.1038/s41467-025-60512-y · Cited by 4
“…asynchronous EPSCs (aEPSCs) and EPSC paired-pulse ratios (PPRs) to identify the synaptic locus of this stress-induced decrease in excitatory transmission. aEPSC amplitude is commonly believed to re ﬂ ect postsynaptic strength 32 while PPRs are an indirect measure of presynaptic release.”
Non-canonical role for Lpar1-EGFP subplate neurons in early postnatal somatosensory cortex
Ghezzi, F., Marques-Smith, A., Anastasiades, P. G., Lyngholm, D., Vagnoni, C., Rowett, A., Hoerder-Suabedissen, A., Nakagawa, Y., Molnár, Z., & Butt, S. (2020) · bioRxiv · doi:10.1101/2020.05.12.088450 · Cited by 4
“Incubation with ACSF containing Sr 2+ (Sr-ACSF) leads to asynchronous vesicular release at the presynaptic terminal providing a reasonable estimate of quantal size 31, 32 .”
Developing Memory Reconsolidation Blockers as Novel PTSD Treatments
Pitman, R., Bolshakov, V., Brunet, A., Nader, K., & Surís, A. (2011) · doi:10.21236/ada579114 · Cited by 4
Neural Circuit Plasticity in Addiction
Anderson, E., & Hearing, M. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812202-0.00004-x · Cited by 9
CIRBP regulates mitochondrial respiratory function and modulates neuronal developmental abnormalities induced by perinatal hypoxia.
Guan, R., Zou, Y., Wang, T., Zhu, X.-Z., Li, M., Zhao, F., Chen, J.-Y., Aschner, M., Zhang, J.-B., & Luo, W.-J. (2025) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2025.05.412 · Cited by 3
Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-Like Physiological and Behavioral Deficits
Dogra, S., Aguayo, C., Xiang, Z., Putnam, J., Smith, J., Johnston, C., Foster, D. J., Lindsley, C. W., Niswender, C. M., & Conn, P. J. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.11.023 · Cited by 4
Synaptic Plasticity in Dissociated Hippocampal Cultures: Pre‐ and Postsynaptic Contributions
Vogt, K., Streit, J., Dityatev, A. E., & Lüscher, H. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01458.x · Cited by 3
CASKIN2 mediates PTPσ-orchestrated transsynaptic mechanisms at excitatory synapses
Han, K. A., Jang, G., Lee, H.-Y., Kim, B., Katano, T., Vas, V., Buday, L., Liu, X., Choi, S., Um, J. W., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2509116122 · Cited by 2
“We also replaced Ca 2+ in the extracellular solution with Sr 2+ , which enters the presynaptic terminal through calcium channels and triggers neurotransmitter release, albeit with lower efficiency ( 32 ).”
A Novel Optical Quantal Analysis of Miniature Events Reveals Enhanced Frequency Following Amyloid β Exposure
Taylor, H. B. C., Tong, R., Jeans, A. F., & Emptage, N. J. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.564081 · Cited by 3
Expression of one group of genes maintains one unit of long-term memory in a brain model.
Wong, C. W. (2000) · Medical Hypotheses · doi:10.1054/mehy.1999.1033 · Cited by 2
In vivo CRF release in rat amygdala is increased during cocaine withdrawal in self-administering rats
Richter, R. M., & Weiss, F. (1999) · Synapse · doi:10.1002/(sici)1098-2396(19990615)32:4 · Cited by 210
Paralogs of Slitrk cell adhesion molecules configure excitatory synapse specificity via distinct cellular mechanisms
Kim, D., Kim, B., Kim, J., Seo, N., Kim, H., Han, K. A., Yoon, J., Macks, C. P., de Wit, J., Sohn, C. H., et al. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003576 · Cited by 1
“Using 8 mM SrCl 2 led to initial modest synchronous responses, followed by an interval of heightened quantal release at both SC synapses and TA synapses. aEPSCs were induced by applying paired stimulation to the SR or SLM layer, delivered as 10 consecutive sweeps at a frequency of 10 Hz [34,35].”
Fusion Pores as Regulators of Quantal Size and Cellular Physiology
Bhaskar, B. R., Mazumdar, S., Dayanandan, S., & Das, D. (2025) · BioEssays · doi:10.1002/bies.70064 · Cited by 2
“In the CA1 region of the mammalian hippocampus, a criticalsiteformemorymodulation,LTPandLTDhavebeenasso-ciated with increases and decreases in quantal size, respectively [163, 164].”
Synaptic properties of layer 6 auditory corticothalamic inputs in normal hearing and noise-induced hearing loss
Zhao, Y.-J., Bizup, B., & Tzounopoulos, T. (2025) · bioRxiv · doi:10.1101/2025.07.08.663770 · Cited by 1
“Quantal events were analyzed (Clampfit 11.2) from a 400 ms window beginning 100 ms after light stimulus (Oliet et al., 1996; Kouvaros et al., 2020).”
Influential
Acute stress causes sex-dependent changes to ventral subiculum synapses, circuitry, and anxiety-like behaviorPreprint
Miller, C. N., Li, Y., Beier, K. T., & Aoto, J. (2024) · bioRxiv · doi:10.1101/2024.08.02.606264 · Cited by 1
“…asynchronous EPSCs (aEPSCs) and EPSC paired-pulse ratios (PPRs) to identify the synaptic locus of this stress-induced decrease in excitatory transmission. aEPSC amplitudes are commonly believed to reflect postsynaptic strength 29 while PPRs are an indirect measure of presynaptic release.”
Background
Divergent pallidal pathways underlying distinct Parkinsonian behavioral deficits
Lilascharoen, V., Wang, E. H., Do, N., Pate, S., Tran, A. N., Wang, X.-Y., Park, Y.-G., Chung, K., & Lim, B. K. (2020) · bioRxiv · doi:10.1101/2020.11.27.401554 · Cited by 1
Analysis of Synaptic Plasticity with the Slice Patch-Clamp Recording Technique
Manabe, T. (2012) · Springer protocols handbooks/Springer protocols · doi:10.1007/978-4-431-53993-3_9 · Cited by 1
Retrograde Messengers in Long-Term Plasticity of Presynaptic Glutamate Release in Hippocampus
Kyrozis, A., Benameur, K., Zhang, X., Winterer, J., Müller, W. S., & Stanton, P. K. (2005) · Springer eBooks · doi:10.1007/0-387-25443-9_17 · Cited by 1
Mechanisms of Synaptic Plasticity in the Brain
Krnjević, K. (2001) · Springer eBooks · doi:10.1007/978-1-4615-1363-6_17
Presynaptic Enhancement of Transmission from Nociceptors Expressing Nav1.8 onto Lamina-I Spinothalamic Tract Neurons by Spared Nerve Injury in Mice
洪瑋辰, W.-C. H., Chen, C., Yen, C.-T., & Min, M. (2024) · eNeuro · doi:10.1523/eneuro.0087-24.2024
“8-STTN EPSCs evoked at normal calcium concentration (Oliet et al., 1996; Xu-Friedman and Regehr, 2000; Cheng et al., 2011).”
Background
Sustained hypoxia reduces GABAergic modulation on NTS neurons sending projections to ventral medulla of rats.
Pascoaloti-Lima, J. C., Machado, B., & Accorsi-Mendonça, D. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2020.12.028
Retracted
Etude de la neuromodulation des réseaux neuronaux du cortex
Meunier, C. N. J. (2013) · theses.fr (ABES) · doi:10.70675/92f28d6dz9071z4072zb306zd7b2a02512b2
“Différentes études supportent l’idée que la LTD est un processus qui tend à renverser les effets observés pendant des processus de LTP puisqu’on observe une diminution des réponses glutamatergiques (Oliet et al. 1996; Kandler et al. 1998; Carroll et al. 1999), mais cette idée reste controversée.”
Background
Endocannabinoids as a Target for the Treatment of Traumatic Brain Injury
Molina, P. (2012) · doi:10.21236/ada599310
“postsynaptic alterations have occurred as a result of TBI.(27,29) Page 19 of 45”
Background
ラット海馬培養神経細胞の自己回帰性シナプス伝達におけるsyntaxin 1A/HPC-1とsyntaxin 1Bの機能
久美子, 藤. (1998) · doi:10.11434/kyorinmed.29.535
Dépression à long-terme des synapses excitatrices dans le cortex et l'hippocampe
Cohen, I., Parra, P., & Miles, R. (1998) · Comptes Rendus de l Académie des Sciences - Series III - Sciences de la Vie · doi:10.1016/s0764-4469(97)89810-1
Morphological Plasticity of the Synapse
Marrone, D. F., LeBoutillier, J. C., & Petit, T. L. (2005) · Springer eBooks · doi:10.1007/0-387-25443-9_28 · Cited by 1
“Quanta1 analysis in CAI has also demonstrated increases in quantal size, potentially reflecting increased probability of quantal release or changes in the number of release sites ( Oliet et al., 1996 ).”
Background

Authors: Oliet, S. H. R., Malenka, R. C., & Nicoll, R. A.
Affiliations: University of California, San Francisco (US)
ORCID: Oliet, Stéphane H. R.
Malenka, Robert C.
Nicoll, Roger A.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1996-03
Volume: 271
Issue: 5253
Pages: 1294-1297
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.271.5253.1294
OpenAlex: W2057637786
Cited by: 209
References: 0
Citations by year: 2025: 7 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 6 · 2012: 6
FWCI: 7.29
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: quantal size, synaptic transmission, long-term potentiation, long-term depression, hippocampal CA1, depotentiation, synaptic plasticity
MeSH terms: Animals, Calcium, Electric Stimulation, Evoked Potentials, Guinea Pigs, Hippocampus, Synaptic Transmission, Neuronal Plasticity, Neurons, Strontium, Synapses, Rats, Sprague-Dawley, Long-Term Potentiation, Receptors, AMPA, Patch-Clamp Techniques, Rats, In Vitro Techniques

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Bidirectional Control of Quantal Size by Synaptic Activity in the Hippocampus

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