CoChat
Sign Up
Cited by 696

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21 WAF1/CIP1 Mediated by STAT1

Chin, Yue E., Kitagawa, Motoo, Su, Wu-Chou S., You, Zhi-Hao, Iwamoto, Yoshiki, Fu, Xin-Yuan·1996·Science
DOI 10.1126/science.272.5262.719
Open this paper in CoChat — free account

Abstract

Signal transducers and activators of transcription (STAT) proteins can be conditionally activated in response to epidermal growth factor (EGF) and interferon (IFN)-γ. STAT activation was correlated with cell growth inhibition in response to EGF and IFN-γ. Activated STAT proteins specifically recognized the conserved STAT-responsive elements in the promoter of the gene encoding the cyclin-dependent kinase (CDK) inhibitor p21 WAF1/CIP1 and regulated the induction of p21 messenger RNA. IFN-γ did not inhibit the growth of U3A cells, which are deficient in STAT1, but did inhibit the growth of U3A cells into which STAT1α was reintroduced. Thus, STAT1 protein is essential for cell growth suppression in response to IFN-γ. The STAT signaling pathway appears to negatively regulate the cell cycle by inducing CDK inhibitors in response to cytokines.

Overview

Integrity signals

Registry

Crossref · 10.1126/science.272.5262.719

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 3 references

Research works printed but not linked: 38

  1. AUSUBEL F.M., CURRENT PROTOCOLS MO (1987).
  2. BRAVO R, STIMULATION AND INHIBITION OF GROWTH BY EGF IN DIFFERENT A431 CELL CLONES IS ACCOMPANIED BY THE RAPID INDUCTION OF C-FOS AND C-MYC PROTO-ONCOGENES, EMBO JOURNAL 4, 1193 (1985). · DOI
  3. 10.1126/science.8197455 · DOI · Paper page
  4. ELDEIRY W.S., WAF1/CIP1 IS INDUCED IN P53-MEDIATED G(1) ARREST AND APOPTOSIS, CANCER RESEARCH 54, 1169 (1994).
  5. ELDEIRY W.S., WAF1, A POTENTIAL MEDIATOR OF P53 TUMOR SUPPRESSION, CELL 75, 817 (1993). · DOI · Paper page
  6. FAN Z, PROLONGED INDUCTION OF P21(CIP1/WAF1)/CDK2/PCNA COMPLEX BY EPIDERMAL GROWTH-FACTOR RECEPTOR ACTIVATION MEDIATES LIGAND-INDUCED A431 CELL-GROWTH INHIBITION, JOURNAL OF CELL BIOLOGY 131, 235 (1995). · DOI
  7. FU X.Y., A TRANSCRIPTION FACTOR WITH SH2 AND SH3 DOMAINS IS DIRECTLY ACTIVATED BY AN INTERFERON-ALPHA-INDUCED CYTOPLASMIC PROTEIN TYROSINE KINASE(S), CELL 70, 323 (1992). · DOI
  8. FU X.Y., TRANSCRIPTION FACTOR P91 INTERACTS WITH THE EPIDERMAL GROWTH-FACTOR RECEPTOR AND MEDIATES ACTIVATION OF THE C-FOS GENE PROMOTER, CELL 74, 1135 (1993). · DOI
  9. FU X.Y., INDUCIBLE GENE EXPRE 2, 99 (1995).
  10. FU X.Y., A DIRECT SIGNALING PATHWAY THROUGH TYROSINE KINASE ACTIVATION OF SH2 DOMAIN-CONTAINING TRANSCRIPTION FACTORS, JOURNAL OF LEUKOCYTE BIOLOGY 57, 529 (1995). · DOI
  11. FU X.Y., ISGF3, THE TRANSCRIPTIONAL ACTIVATOR INDUCED BY INTERFERON-ALPHA, CONSISTS OF MULTIPLE INTERACTING POLYPEPTIDE-CHAINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87, 8555 (1990).
  12. FU X.Y., THE PROTEINS OF ISGF-3, THE INTERFERON ALPHA-INDUCED TRANSCRIPTIONAL ACTIVATOR, DEFINE A GENE FAMILY INVOLVED IN SIGNAL TRANSDUCTION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89, 7840 (1992).
  13. GILL G.N., INCREASED PHOSPHOTYROSINE CONTENT AND INHIBITION OF PROLIFERATION IN EGF-TREATED A431 CELLS, NATURE 293, 305 (1981). · DOI
  14. GU Y, INHIBITION OF CDK2 ACTIVITY IN-VIVO BY AN ASSOCIATED 20K REGULATORY SUBUNIT, NATURE 366, 707 (1993). · DOI
  15. GUTCH M.J., TYROSINE PHOSPHORYLATION IS REQUIRED FOR ACTIVATION OF AN ALPHA-INTERFERON-STIMULATED TRANSCRIPTION FACTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89, 11411 (1992). · DOI
  16. HAMBURGER A.W., PRIMARY BIOASSAY OF HUMAN TUMOR STEM-CELLS, SCIENCE 197, 461 (1977). · DOI
  17. HARPER J.W., THE P21 CDK-INTERACTING PROTEIN CIP1 IS A POTENT INHIBITOR OF G1 CYCLIN-DEPENDENT KINASES, CELL 75, 805 (1993). · DOI · Paper page
  18. HARPER J.W., INHIBITION OF CYCLIN-DEPENDENT KINASES BY P21, MOLECULAR BIOLOGY OF THE CELL 6, 387 (1995). · DOI
  19. HUNTER T, CYCLINS AND CANCER .2. CYCLIN-D AND CDK INHIBITORS COME OF AGE, CELL 79, 573 (1994). · DOI
  20. IHLE J.N., CYTOKINE RECEPTOR SIGNALING, NATURE 377, 591 (1995). · DOI
  21. KARIN M, TRANSCRIPTIONAL CONTROL BY PROTEIN-PHOSPHORYLATION - SIGNAL TRANSMISSION FROM THE CELL-SURFACE TO THE NUCLEUS, CURRENT BIOLOGY 5, 747 (1995). · DOI
  22. KATOH K, IMPROVED MAMMALIAN VECTORS FOR HIGH EXPRESSION OF G418 RESISTANCE, CELL STRUCTURE AND FUNCTION 12, 575 (1987). · DOI
  23. KWOK T.T., UP-REGULATION OF A MUTANT FORM OF P53 BY DOXORUBICIN IN HUMAN SQUAMOUS CARCINOMA-CELLS, CANCER RESEARCH 54, 2834 (1994).
  24. LAMER A.C., SCIENCE 261, 1730 (1993). · DOI
  25. LEVY D.E., CYTOPLASMIC ACTIVATION OF ISGF3, THE POSITIVE REGULATOR OF INTERFERON-ALPHA-STIMULATED TRANSCRIPTION, RECONSTITUTED INVITRO, GENES & DEVELOPMENT 3, 1362 (1989). · DOI
  26. MCKENDRY R, HIGH-FREQUENCY MUTAGENESIS OF HUMAN-CELLS AND CHARACTERIZATION OF A MUTANT UNRESPONSIVE TO BOTH ALPHA INTERFERON AND GAMMA INTERFERON, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88, 11455 (1991). · DOI
  27. MULLER M, COMPLEMENTATION OF A MUTANT-CELL LINE - CENTRAL ROLE OF THE 91-KDA POLYPEPTIDE OF ISGF3 IN THE INTERFERON-ALPHA AND INTERFERON-GAMMA SIGNAL-TRANSDUCTION PATHWAYS, EMBO JOURNAL 12, 4221 (1993). · DOI · Paper page
  28. MULLER M, THE PROTEIN-TYROSINE KINASE JAK1 COMPLEMENTS DEFECTS IN INTERFERON-ALPHA/BETA AND INTERFERON-GAMMA SIGNAL-TRANSDUCTION, NATURE 366, 129 (1993). · DOI
  29. RESNITZKY D, INTERFERONS AND INTERLEUKIN-6 SUPPRESS PHOSPHORYLATION OF THE RETINOBLASTOMA PROTEIN IN GROWTH-SENSITIVE HEMATOPOIETIC-CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89, 402 (1992). · DOI
  30. RUFFJAMISON S, EPIDERMAL GROWTH-FACTOR AND LIPOPOLYSACCHARIDE ACTIVATE STAT3 TRANSCRIPTION FACTOR IN MOUSE-LIVER, JOURNAL OF BIOLOGICAL CHEMISTRY 269, 21933 (1994). · DOI
  31. RUFFJAMISON S, INDUCTION BY EGF AND INTERFERON-GAMMA OF TYROSINE-PHOSPHORYLATED DNA-BINDING PROTEINS IN MOUSE-LIVER NUCLEI, SCIENCE 261, 1733 (1993). · DOI
  32. SADOWSKI H.B., CELL-FREE ACTIVATION OF A DNA-BINDING PROTEIN BY EPIDERMAL GROWTH-FACTOR, NATURE 362, 79 (1993). · DOI
  33. SADOWSKI H.B., A COMMON NUCLEAR SIGNAL-TRANSDUCTION PATHWAY ACTIVATED BY GROWTH-FACTOR AND CYTOKINE RECEPTORS, SCIENCE 261, 1739 (1993). · DOI
  34. SHERR C.J., INHIBITORS OF MAMMALIAN G(1) CYCLIN-DEPENDENT KINASES, GENES & DEVELOPMENT 9, 1149 (1995). · DOI
  35. VELAZQUEZ L, A PROTEIN TYROSINE KINASE IN THE INTERFERON-ALPHA/BETA SIGNALING PATHWAY, CELL 70, 313 (1992). · DOI
  36. WAGNER B.J., THE SIF BINDING-ELEMENT CONFERS SIS/PDGF INDUCIBILITY ONTO THE C-FOS PROMOTER, EMBO JOURNAL 9, 4477 (1990). · DOI · Paper page
  37. 10.1038/366701a0 · DOI
  38. ZHANG H, P21-CONTAINING CYCLIN KINASES EXIST IN BOTH ACTIVE AND INACTIVE STATES, GENES & DEVELOPMENT 8, 1750 (1994). · DOI

Cited by

See all 696

Metadata

Authors
Chin, Y. E., Kitagawa, M., Su, W.-C. S., You, Z.-H., Iwamoto, Y., & Fu, X.-Y.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1996-05-03
Volume
272
Issue
5262
Pages
719-722
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.272.5262.719
Cited by
696
References
3
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21 WAF1/CIP1 Mediated by STAT1. https://app.cochat.ai/papers/10.1126/science.272.5262.719
The paper
Chin, Y. E., Kitagawa, M., Su, W.-C. S., You, Z.-H., Iwamoto, Y., & Fu, X.-Y. (1996). Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21 WAF1/CIP1 Mediated by STAT1. Science. https://doi.org/10.1126/science.272.5262.719