The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
The Aging Immune System: Primer and Prospectus
Abstract
Changes in T lymphocyte populations underlie much of the age-related decline in the protective immune response. Aging leads to the replacement of virgin T cells by memory T cells and to the accumulation of cells with signal transduction defects. Studies of antibody gene assembly, accessory cell function, post-thymic T cell development, skewed selection of T cell receptor repertoire, and the clinical concomitants of immune senescence will shed new light on the causes and consequences of age-dependent immune failure.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The ageing immune system is characterised by a decline in stem cells, alterations in T-lymphocyte production, blunting of the B-cell led antibody response and reduced phagocytic activity of neutrophils, macrophages and natural killer cells (50, 51).”
From Frailty in elderly people (2013) · cites this paper as [51]
Citations
Cites
The Physiology of Reproduction
Legendre, M., & Jalabert, B. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-2-176_1 · Cited by 7,876
Daynes, R. A., Araneo, B. A., Ershler, W. B., Maloney, C., Li, G. Z., & Ryu, S. Y. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.12.5219 · Cited by 1,264
Posnett, D. N., Sinha, R., Kabak, S., & Russo, C. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.2.609 · Cited by 761
Cytotoxic T-cell memory without antigen
Lau, L. L., Jamieson, B. D., Somasundaram, T., & Ahmed, R. (1994) · Nature · doi:10.1038/369648a0 · Cited by 657
Letter: Hypoglycaemia in propranolol-treated dialysis patients.
Jensen, H. A., Bjaeldager, P., & Broch‐Møller, B. (1976) · PubMed · Cited by 649
Scollay, R. G., Butcher, E. C., & Weissman, I. L. (1980) · European Journal of Immunology · doi:10.1002/eji.1830100310 · Cited by 555
AGEING, IMMUNE RESPONSE, AND MORTALITY
Roberts-Thomson, I., Youngchaiyud, U., Whittingham, S., & Mackay, I. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91755-3 · Cited by 477
Gillis, S. A., Kozak, R. W., Durante, M., & Weksler, M. E. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110143 · Cited by 472
Human naive and memory T lymphocytes differ in telomeric length and replicative potential.
Weng, N., Levine, B. L., June, C. H., & Hodes, R. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11091 · Cited by 418
Ferguson, F. G., Wikby, A., Maxson, P., Olsson, J., & Johansson, B. (1995) · The Journals of Gerontology Series A · doi:10.1093/gerona/50a.6.b378 · Cited by 378
Flagged first, then by citations
Research works printed but not linked: 8
- CHEN Y, AGING IMMUNOL INFECT 4, 155 (1993).
- GAUCHAT J.F., AGING IMMUNOL INFECT 1, 191 (1988).
- KLINMAN N.R., AGING IMMUNOL INFECT 5, 203 (1994).
- LI S.P., AGING IMMUNOL INFECT 6, 79 (1995).
- MILLER C, AGING IMMUNOL INFECT 5, 249 (1994).
- MILLER R.A., HBK PHYSIOL: 555 (1995).
- MURASKO D.M., ANNU REV GERONTOL 10, 71 (1990).
- SCHULZE D.H., AGING IMMUNOL INFECT 3, 127 (1992).
Cited by
Sorted by citations
Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62167-9 · Cited by 9,503
Influenza-Associated Hospitalizations in the United States
Thompson, W. W. (2004) · JAMA · doi:10.1001/jama.292.11.1333 · Cited by 2,213
“Consideration should also be given to other influenza prevention methods for older Americans given the potential for decreased immune responsiveness to vaccines in the very elderly.(40,41) After the elderly, the second highest rates of influenza-associated hospitalizations are found in young children.”
BackgroundDisease Tolerance as a Defense Strategy
Medzhitov, R., Schneider, D. S., & Soares, M. P. (2012) · Science · doi:10.1126/science.1214935 · Cited by 1,718
DNA methylation-based measures of biological age: meta-analysis predicting time to death
Chen, B. H., Marioni, R. E., Colicino, E., Peters, M. J., Ward-Caviness, C. K., Tsai, P.-C., Roetker, N. S., Just, A. C., Demerath, E. W., Guan, W., et al. (2016) · Aging · doi:10.18632/aging.101020 · Cited by 1,126
Sex hormones and the immune response in humans
Bouman, A., Heineman, M. J., & Faas, M. M. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi008 · Cited by 1,131
“One of these factors may be related with ageing (Miller, 1996; Chakravarti and Abraham, 1999).”
Background
Metadata
- Authors
- Miller, R. A.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Miller, Richard A.
- ORCID
- Miller, Richard A.
- Venue
- Science
- Published
- 1996-07-05
- Volume
- 273
- Issue
- 5271
- Pages
- 70-74
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2043464691
- Cited by
- 1,165
- References
- 71
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 15 · 2023: 19 · 2022: 9 · 2021: 22 · 2020: 34 · 2019: 25 · 2018: 33 · 2017: 32 · 2016: 24 · 2015: 31 · 2014: 26 · 2013: 40 · 2012: 35
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- immunosenescence, aging, T cells, memory T cells, T cell receptor repertoire, signal transduction defects, accessory cell function, age-related immune decline
- MeSH terms
- Aged, Aged, 80 and over, Aging, Animals, Antibody Formation, Antigen-Presenting Cells, B-Lymphocytes, Cytotoxicity, Immunologic, Disease Susceptibility, Humans, Immune System, Immunologic Memory, Killer Cells, Natural, Longevity, Receptors, Antigen, T-Cell, T-Lymphocytes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
