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Evolution of the human lifespan, past, present, and future: phases in the evolution of human life expectancy in relation to the inflammatory load.

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T cell receptor-mediated activation is a potent inducer of macroautophagy in human CD8(+)CD28(+) T cells but not in CD8(+)CD28(-) T cells

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Impaired Immune Response to Primary but Not to Booster Vaccination Against Hepatitis B in Older Adults

Weinberger, B., Haks, M. C., de Paus, R. A., Ottenhoff, T. H. M., Bauer, T., & Grubeck‐Loebenstein, B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01035 · Cited by 39 · see citing works

Differences in clinical characteristics of IgG4-related disease across age groups: a prospective study of 737 patients

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Pulmonary Diseases and Ageing

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DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus

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Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis

Lü, X., Yang, Y.-M., & Lu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.917293 · Cited by 35 · see citing works

Effect of aging on microRNAs and regulation of pathogen recognition receptors

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Tuberculosis, the Disrupted Immune-Endocrine Response and the Potential Thymic Repercussion As a Contributing Factor to Disease Physiopathology

D’Attilio, L., Santucci, N. E., Bongiovanni, B., Bay, M. L., & Bottasso, O. A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00214 · Cited by 35 · see citing works

CD8+HLADR+ Regulatory T Cells Change With Aging: They Increase in Number, but Lose Checkpoint Inhibitory Molecules and Suppressive Function

Yani, S. L., Keller, M., Melzer, F. L., Weinberger, B., Pangrazzi, L., Sopper, S., Trieb, K., Lobina, M., Orrù, V., Fiorillo, E., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01201 · Cited by 33 · see citing works

The immunoregulatory effects of CMV-infection in human fibroblasts and the impact on cellular senescence

Wolf, J., Weinberger, B., & Grubeck‐Loebenstein, B. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-1 · Cited by 33 · see citing works

Altered regulation of CXCR4 expression during aging contributes to increased CXCL12‐dependent chemotactic migration of CD4+ T cells

Canè, S., Ponnappan, S., & Ponnappan, U. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00830.x · Cited by 32 · see citing works

Vaccines for the Elderly

Giudice, G. D., Weinberger, B., & Grubeck‐Loebenstein, B. (2014) · Gerontology · doi:10.1159/000366162 · Cited by 32 · see citing works

Phase I, randomized, observer-blind, placebo-controlled studies to evaluate the safety, reactogenicity and immunogenicity of an investigational non-typeable Haemophilus influenzae (NTHi) protein vaccine in adults

Leroux-Roels, G. G., Damme, P. V., Haazen, W., Shakib, S., Caubet, M., Aris, E., Devaster, J., & Peeters, M. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.04.051 · Cited by 32 · see citing works

Age-Associated Changes in Estrogen Receptor Ratios Correlate with Increased Female Susceptibility to Coxsackievirus B3-Induced Myocarditis

Koenig, A., Buskiewicz, I. A., & Huber, S. A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01585 · Cited by 32 · see citing works

Concentric and Eccentric Endurance Exercise Reverse Hallmarks of T-Cell Senescence in Pre-diabetic Subjects

Philippe, M., Gatterer, H., Burtscher, M., Weinberger, B., Keller, M., Grubeck‐Loebenstein, B., Fleckenstein, J., Alack, K., & Krüger, K. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00684 · Cited by 32 · see citing works

Age-Dependent Gender Disparities in Post Lung Transplant Survival Among Patients With Idiopathic Pulmonary Fibrosis

Sheikh, S. I., Hayes, D., Kirkby, S. E., Tobias, J. D., & Tumin, D. (2016) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2016.08.083 · Cited by 31 · see citing works

Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice

Huang, T., Chen, C.-C., Liu, H.-M., Lee, T.-Y., & Shieh, S.-H. (2017) · Scientific Reports · doi:10.1038/s41598-017-02881-z · Cited by 27 · see citing works

Effect of Different Immunosuppressive Drugs on Immune Cells from Young and Old Healthy Persons

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Characterization of senescence biomarkers in rheumatoid arthritis: relevance to disease progression

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Spleen Cells from Young but Not Old Immunized Mice Eradicate Large Established Cancers

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Molecular Signatures of Immunity and Immunogenicity in Infection and Vaccination

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CD28null T cells in aging and diseases: From biology to assessment and intervention

Guan, Y., Cao, M., Wu, X., Yan, J., Hao, Y., & Zhang, C. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111807 · Cited by 26 · see citing works

The SENIEUR protocol and the efficacy of hepatitis B vaccination in healthy elderly persons by age, gender, and vaccine route

Edelman, R., Deming, M. E., Toapanta, F. R., Heuser, M. D., Chrisley, L., Barnes, R. S., Wasserman, S. S., Blackwelder, W. C., Handwerger, B. S., Pasetti, M. F., et al. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00179-9 · Cited by 24 · see citing works

Vaccine-preventable diseases: From paediatric to adult targets

Esposito, S., Durando, P., Bosis, S., Ansaldi, F., Tagliabue, C., & Icardi, G. (2014) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2013.12.004 · Cited by 24 · see citing works

The impact of oxidative stress, inflammation, and senescence on the maintenance of immunological memory in the bone marrow in old age

Naismith, E., & Pangrazzi, L. (2019) · Bioscience Reports · doi:10.1042/bsr20190371 · Cited by 24 · see citing works

Comprehensive Analysis of the Neutrophil‐to‐Lymphocyte Ratio for Preoperative Prognostic Prediction Nomogram in Gastric Cancer

Choi, J., Suh, Y., Choi, Y., Han, J., Kim, T. H., Park, S., Kong, S., Lee, H., & Yang, H. (2018) · World Journal of Surgery · doi:10.1007/s00268-018-4510-4 · Cited by 23 · see citing works

Immunosenescence of the CD8+ T cell compartment is associated with HIV-infection, but only weakly reflects age-related processes of adipose tissue, metabolism, and muscle in antiretroviral therapy-treated HIV-infected patients and controls

Tavenier, J., Langkilde, A., Haupt, T. H., Henriksen, J. H., Jensen, F. K., Petersen, J., & Andersen, O. (2015) · BMC Immunology · doi:10.1186/s12865-015-0136-6 · Cited by 22 · see citing works

BTLA expression declines on B cells of the aged and is associated with low responsiveness to the trivalent influenza vaccine

Kannan, S., Kurupati, R. K., Doyle, S. A., Freeman, G. J., Schmader, K. E., & Ertl, H. C. J. (2015) · Oncotarget · doi:10.18632/oncotarget.4597 · Cited by 21 · see citing works

Thymic Engraftment by in vitro-Derived Progenitor T Cells in Young and Aged Mice

Singh, J., Mohtashami, M., Anderson, G., & Zúñiga‐Pflücker, J. C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01850 · Cited by 20 · see citing works

The Hayflick Limit and Age-Related Adaptive Immune Deficiency

Gill, Z., Nieuwoudt, M., & Ndifon, W. O. (2017) · Gerontology · doi:10.1159/000478091 · Cited by 19 · see citing works

Clinical benefit of immune checkpoint inhibitors in elderly cancer patients: Current evidence from immunosenescence pathophysiology to clinical trial results

Ziogas, D. C., Theocharopoulos, C., Aravantinou-Fatorou, K., Boukouris, A. E., Stefanou, D. T., Anastasopoulou, A. N., Lialios, P., Lyrarakis, G., & Gogas, H. J. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104635 · Cited by 19 · see citing works

MLH1 Region Polymorphisms Show a Significant Association with CpG Island Shore Methylation in a Large Cohort of Healthy Individuals

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Novel Intervention in the Aging Population: A Primary Meningococcal Vaccine Inducing Protective IgM Responses in Middle-Aged Adults

van der Heiden, M., Boots, A. M. H., Marinović, A. A. B., de Rond, L., van Maurik, M., Tcherniaeva, I., Berbers, G. A. M., & Buisman, A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00817 · Cited by 17 · see citing works

Tetanus Toxoid carrier protein induced T-helper cell responses upon vaccination of middle-aged adults

van der Heiden, M., Duizendstra, A. A., Berbers, G. A. M., Boots, A. M. H., & Buisman, A. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.08.056 · Cited by 17 · see citing works

T cell senescence predicts subclinical atherosclerosis in HIV-infected patients similarly to traditional cardiovascular risk factors

Bernal, E., Martínez, M. M., Torres, A., Guillamón, C. F., Alcaraz, A., García, M. J. A., Muñoz, Á., Valero, S., Botella, C., Campillo, J. A., et al. (2018) · Antiviral Research · doi:10.1016/j.antiviral.2018.12.014 · Cited by 16 · see citing works

The clinical trajectory of peripheral blood immune cell subsets, T-cell activation, and cytokines in septic patients

Lü, X., Song, C., Wang, P., Li, L., Lin, L.-Y., Jiang, S., Zhou, J.-N., Feng, M.-X., Yang, Y., & Lu, Y. (2023) · Inflammation Research · doi:10.1007/s00011-023-01825-w · Cited by 15 · see citing works

Treatment‐related risk factors for inhibitor development in non‐severe hemophilia A after 50 cumulative exposure days: A case‐control study

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The CD3-Zeta Chimeric Antigen Receptor Overcomes TCR Hypo-Responsiveness of Human Terminal Late-Stage T Cells

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Immune senescence: A key player in cancer biology

Yang, Y., Fan, L., Li, M., & Wang, Z. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.12.001 · Cited by 13 · see citing works

Pre-Existing Hypertension Is Related with Disproportions in T-Lymphocytes in Older Age

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B cell responses to the 2011/12-influenza vaccine in the aged

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EBV-specific CD8 T lymphocytes and B cells during glatiramer acetate therapy in patients with MS

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Limited restoration of T cell subset distribution and immune function in older people living with HIV-1 receiving HAART

Li, N., Zheng, H., Li, W., He, X.-Y., Zhang, M., Li, X., Tian, R.-R., Dong, X.-Q., Shen, Z., & Zheng, Y. (2025) · Immunity & Ageing · doi:10.1186/s12979-024-00497-2 · Cited by 12 · see citing works

Attenuation of migration properties of CD4+ T cells from aged mice correlates with decrease in chemokine receptor expression, response to retinoic acid, and RALDH expression compared to young mice

Park, J., Miyakawa, T., Shiokawa, A., Nakajima‐Adachi, H., Tanokura, M., & Hachimura, S. (2014) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2014.910099 · Cited by 11 · see citing works

Re-evaluating CD57 as a marker of T cell senescence: implications for immune ageing and differentiation

Autaa, G., Korenkov, D. A., van Beek, J., Pellegrin, I., Parfait, B., van Baarle, D., Launay, O., Tartour, É., & Appay, V. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00542-8 · Cited by 10 · see citing works

Chronic Stress and Latent Virus Reactivation: Effects on Immune Aging, Chronic Disease Morbidity, and Mortality

Klopack, E. T. (2023) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbad087 · Cited by 11 · see citing works

Aging, Immunity, and Neuroinflammation: The Modulatory Potential of Nutrition

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Grundlagen der biologischen Alterung

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T cells, aging and senescence

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Impact of Aging on T Cell Repertoire and Immunity

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Better safe than sorry: Naive T-cell dynamics in healthy ageing

de Boer, R. J., Tesselaar, K., & Borghans, J. A. M. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101839 · Cited by 19 · see citing works

General and individualized changes in T cell immunity during aging

Song, N., Elbahnasawy, M. A., & Weng, N. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkae033 · Cited by 11 · see citing works

Immunosenescence in Humans: Changes to the Aged T Lymphocyte Population in Response to Persistent Cytomegalovirus Infection

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