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Persistent Site-Specific Remodeling of a Nucleosome Array by Transient Action of the SWI/SNF Complex

Owen-Hughes, T., Utley, R. T., Côté, J., Peterson, C. L., Workman, J. L.·1996·Science
DOI 10.1126/science.273.5274.513
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Abstract

The SWI/SNF complex participates in the restructuring of chromatin for transcription. The function of the yeast SWI/SNF complex in the remodeling of a nucleosome array has now been analyzed in vitro. Binding of the purified SWI/SNF complex to a nucleosome array disrupted multiple nucleosomes in an adenosine triphosphate-dependent reaction. However, removal of SWI/SNF left a deoxyribonuclease I-hypersensitive site specifically at a nucleosome that was bound by derivatives of the transcription factor Gal4p. Analysis of individual nucleosomes revealed that the SWI/SNF complex catalyzed eviction of histones from the Gal4-bound nucleosomes. Thus, the transient action of the SWI/SNF complex facilitated irreversible disruption of transcription factor-bound nucleosomes.

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Research works printed but not linked: 34

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Cited by

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Metadata

Authors
Owen-Hughes, T., Utley, R. T., Côté, J., Peterson, C. L., & Workman, J. L.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1996-07-26
Volume
273
Issue
5274
Pages
513-516
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.273.5274.513
OpenAlex
W2064205106
Cited by
224
References
0
FWCI
10.64
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Persistent Site-Specific Remodeling of a Nucleosome Array by Transient Action of the SWI/SNF Complex. https://app.cochat.ai/papers/10.1126/science.273.5274.513
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Owen-Hughes, T., Utley, R. T., Côté, J., Peterson, C. L., & Workman, J. L. (1996). Persistent Site-Specific Remodeling of a Nucleosome Array by Transient Action of the SWI/SNF Complex. Science. https://doi.org/10.1126/science.273.5274.513

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