The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Role of Postreplicative DNA Mismatch Repair in the Cytotoxic Action of Thioguanine
Abstract
It is proposed here that the delayed cytotoxicity of thioguanine involves the postreplicative DNA mismatch repair system. After incorporation into DNA, the thioguanine is chemically methylated by S -adenosylmethionine to form S 6 -methylthioguanine. During DNA replication, the S 6 -methylthioguanine directs incorporation of either thymine or cytosine into the growing DNA strand, and the resultant S 6 -methylthioguanine-thymine pairs are recognized by the postreplicative mismatch repair system. Azathioprine, an immunosuppressant used in organ transplantation, is partly converted to thioguanine. Because the carcinogenicity of N -nitrosamines depends on formation of O 6 -alkylguanine in DNA, the formation of the analog S 6 -methylthioguanine during azathioprine treatment may partly explain the high incidence of cancer after transplantation.
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Cites
The purine path to chemotherapy
Elion, G. B. (1989) · Science · doi:10.1126/science.2649979 · Cited by 687
An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.
Kat, A., Thilly, W. G., Fang, W. H., Longley, M. J., Li, G. M., & Modrich, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6424 · Cited by 443
Rydberg, B., & Lindahl, T. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01149.x · Cited by 409
Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage
Branch, P., Aquilina, G., Bignami, M., & Karran, P. (1993) · Nature · doi:10.1038/362652a0 · Cited by 362
Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint.
Hawn, M. T., Umar, A., Carethers, J. M., Marra, G., Kunkel, T. A., Boland, C. R., & Koi, M. (1995) · PubMed · Cited by 360
DNA damage tolerance, mismatch repair and genome instability
Karran, P., & Bignami, M. (1994) · BioEssays · doi:10.1002/bies.950161110 · Cited by 310
Mismatch correction at O6-methylguanine residues in E. coli DNA
Karran, P., & Marinus, M. G. (1982) · Nature · doi:10.1038/296868a0 · Cited by 216
Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro
Barrows, L. R., & Magee, P. N. (1982) · Carcinogenesis · doi:10.1093/carcin/3.3.349 · Cited by 160
A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches.
Jiricny, J., Hughes, M., Corman, N., & Rudkin, B. B. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.8860 · Cited by 122
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Cited by
DNA repair pathways as targets for cancer therapy
Helleday, T., Petermann, E., Lundin, C., Hodgson, B., & Sharma, R. A. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2342 · Cited by 1,666
The multifaceted mismatch-repair system
Jiricny, J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1907 · Cited by 1,370
DNA Mismatch Repair: Functions and Mechanisms
Iyer, R. R., Pluciennik, A., Burdett, V., & Modrich, P. L. (2006) · Chemical Reviews · doi:10.1021/cr0404794 · Cited by 905
Karran, P., & Attard, N. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2292 · Cited by 477
NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity
Moriyama, T., Nishii, R., Perez-Andreu, V., Yang, W., Klussmann, F. A., Zhao, X., Lin, T.-N., Hoshitsuki, K., Nersting, J., Kihira, K., et al. (2016) · Nature Genetics · doi:10.1038/ng.3508 · Cited by 477
Metadata
- Authors
- Swann, P. F., Waters, T. R., Moulton, D. C., Xu, Y.-Z., Zheng, Q., Edwards, M., & Mace, R.
- Venue
- Science
- Published
- 1996-08-23
- Volume
- 273
- Issue
- 5278
- Pages
- 1109-1111
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1974292630
- Cited by
- 408
- References
- 18
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Swann, P. F., Waters, T. R., Moulton, D. C., Xu, Y.-Z., Zheng, Q., Edwards, M., & Mace, R. (1996). Role of Postreplicative DNA Mismatch Repair in the Cytotoxic Action of Thioguanine. Science. https://doi.org/10.1126/science.273.5278.1109
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
