The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Maintenance of Acetylcholine Receptor Number by Neuregulins at the Neuromuscular Junction in Vivo
Abstract
ARIA (for acetylcholine receptor–inducing activity), a protein purified on the basis of its ability to stimulate acetylcholine receptor (AChR) synthesis in cultured myotubes, is a member of the neuregulin family and is present at motor endplates. This suggests an important role for neuregulins in mediating the nerve-dependent accumulation of AChRs in the postsynaptic membrane. Nerve-muscle synapses have now been analyzed in neuregulin-deficient animals. Mice that are heterozygous for the deletion of neuregulin isoforms containing an immunoglobulin-like domain are myasthenic. Postsynaptic AChR density is significantly reduced, as judged by the decrease in the mean amplitude of spontaneous miniature endplate potentials and bungarotoxin binding. On the other hand, the mean amplitude of evoked endplate potentials was not decreased, due to an increase in the number of quanta released per impulse, a compensation that has been observed in other myasthenic states. Thus, the density of AChRs in the postsynaptic membrane depends on immunoglobulin-containing neuregulin isoforms throughout the life of the animal.
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Citations
Cites
Requirement for neuregulin receptor erbB2 in neural and cardiac development
Lee, K.-F., Simon, H., Chen, H., Bates, B., Hung, M.-C., & Hauser, C. (1995) · Nature · doi:10.1038/378394a0 · Cited by 1,290
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
Gassmann, M., Casagranda, F., Orioli, D., Simon, H., Lai, C., Klein, R., & Lemke, G. (1995) · Nature · doi:10.1038/378390a0 · Cited by 1,148
Identification of Heregulin, a Specific Activator of p185 erbB2
Holmes, W. E., Sliwkowski, M. X., Akita, R. W., Henzel, W. J., Lee, J., Park, J. W., Yansura, D., Abadi, N., Raab, H., Lewis, G. D., et al. (1992) · Science · doi:10.1126/science.256.5060.1205 · Cited by 962
Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice
Gautam, M., Noakes, P. G., Moscoso, L., Rupp, F., Scheller, R. H., Merlie, J. P., & Sanes, J. R. (1996) · Cell · doi:10.1016/s0092-8674(00)81253-2 · Cited by 934
Synaptic structure and development: The neuromuscular junction
Hall, Z. W., & Sanes, J. R. (1993) · Cell · doi:10.1016/s0092-8674(05)80031-5 · Cited by 834
Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system
Marchionni, M. A., Goodearl, A. D. J., Su Chen, M., Bermingham-McDonogh, O., Kirk, C., Hendricks, M., Danehy, F., Misumi, D., Sudhalter, J., Kobayashi, K., et al. (1993) · Nature · doi:10.1038/362312a0 · Cited by 738
McMahan, U. J. (1990) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1990.055.01.041 · Cited by 641
Falls, D. (1993) · Cell · doi:10.1016/0092-8674(93)90407-h · Cited by 607
Wen, D., Peles, E., Cupples, R., Suggs, S. V., Bacus, S. S., Luo, Y., Trail, G., Hu, S., Silbiger, S. M., Levy, R. B., et al. (1992) · Cell · doi:10.1016/0092-8674(92)90456-m · Cited by 577
Gautam, M., Noakes, P. G., Mudd, J., Nichol, M., Chu, G. C., Sanes, J. R., & Merlie, J. P. (1995) · Nature · doi:10.1038/377232a0 · Cited by 545
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Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485
DEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION
Sanes, J. R., & Lichtman, J. W. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.389 · Cited by 1,532
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Mei, L., & Xiong, W.-C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2392 · Cited by 1,030
Severe neuropathies in mice with targeted mutations in the ErbB3 receptor
Riethmacher, D., Sonnenberg-Riethmacher, E., Brinkmann, V., Yamaai, T., Lewin, G. R., & Birchmeier, C. (1997) · Nature · doi:10.1038/39593 · Cited by 729
Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases
Mei, L., & Nave, K.-A. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.007 · Cited by 592
Metadata
- Authors
- Sandrock, A. W., Dryer, S. E., Rosen, K. M., Gozani, S. N., Kramer, R., Theill, L. E., & Fischbach, G. D.
- Venue
- Science
- Published
- 1997-04-25
- Volume
- 276
- Issue
- 5312
- Pages
- 599-603
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013331112
- Cited by
- 273
- References
- 36
- FWCI
- 17.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sandrock, A. W., Dryer, S. E., Rosen, K. M., Gozani, S. N., Kramer, R., Theill, L. E., & Fischbach, G. D. (1997). Maintenance of Acetylcholine Receptor Number by Neuregulins at the Neuromuscular Junction in Vivo. Science. https://doi.org/10.1126/science.276.5312.599
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