The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Prevention of Mucosal Escherichia coli Infection by FimH-Adhesin-Based Systemic Vaccination
Abstract
Virtually all uropathogenic strains of Escherichia coli , the primary cause of cystitis, assemble adhesive surface organelles called type 1 pili that contain the FimH adhesin. Sera from animals vaccinated with candidate FimH vaccines inhibited uropathogenic E. coli from binding to human bladder cells in vitro. Immunization with FimH reduced in vivo colonization of the bladder mucosa by more than 99 percent in a murine cystitis model, and immunoglobulin G to FimH was detected in urinary samples from protected mice. Furthermore, passive systemic administration of immune sera to FimH also resulted in reduced bladder colonization by uropathogenic E. coli . This approach may represent a means of preventing recurrent and acute infections of the urogenital mucosa.
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Citations
Cites
Beachey, E. H. (1981) · Journal of Infectious Diseases · doi:10.1093/infdis/143.3.325 · Cited by 1,411
Pilus and nonpilus bacterial adhesins: Assembly and function in cell recognition
Hultgren, S. J., Abraham, S., Caparon, M., Falk, P., Geme, J. W. S., & Normark, S. (1993) · Cell · doi:10.1016/0092-8674(93)90269-v · Cited by 409
Self-citation
Cited by
Johnson, J. R., & Stell, A. L. (2000) · The Journal of Infectious Diseases · doi:10.1086/315217 · Cited by 1,269
Russo, T. A., & Johnson, J. R. (2003) · Microbes and Infection · doi:10.1016/s1286-4579(03)00049-2 · Cited by 801
Type 1 pilus-mediated bacterial invasion of bladder epithelial cells
Martinez, J. J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.12.2803 · Cited by 758
Origins and virulence mechanisms of uropathogenic Escherichia coli
Wiles, T. J., Kulesus, R. R., & Mulvey, M. A. (2008) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2008.03.007 · Cited by 606
Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis
Kain, R., Exner, M., Brandes, R., Ziebermayr, R., Cunningham, D., Alderson, C. A., Davidovits, A., Raab, I., Jahn, R., Ashour, O., et al. (2008) · Nature Medicine · doi:10.1038/nm.1874 · Cited by 455
Metadata
- Authors
- Langermann, S., Palaszynski, S., Barnhart, M., Auguste, G., Pinkner, J. S., Burlein, J., Barren, P., Koenig, S., Leath, S., Jones, C. H., & Hultgren, S. J.
- Venue
- Science
- Published
- 1997-04-25
- Volume
- 276
- Issue
- 5312
- Pages
- 607-611
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2162749433
- Cited by
- 577
- References
- 2
- FWCI
- 18.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Langermann, S., Palaszynski, S., Barnhart, M., Auguste, G., Pinkner, J. S., Burlein, J., Barren, P., Koenig, S., Leath, S., Jones, C. H., & Hultgren, S. J. (1997). Prevention of Mucosal Escherichia coli Infection by FimH-Adhesin-Based Systemic Vaccination. Science. https://doi.org/10.1126/science.276.5312.607
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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