The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Import of Mitochondrial Carriers Mediated by Essential Proteins of the Intermembrane Space
Abstract
In order to reach the inner membrane of the mitochondrion, multispanning carrier proteins must cross the aqueous intermembrane space. Two essential proteins of that space, Tim10p and Tim12p, were shown to mediate import of multispanning carriers into the inner membrane. Both proteins formed a complex with the inner membrane protein Tim22p. Tim10p readily dissociated from the complex and was required to transport carrier precursors across the outer membrane; Tim12p was firmly bound to Tim22p and mediated the insertion of carriers into the inner membrane. Neither protein was required for protein import into the other mitochondrial compartments. Both proteins may function as intermembrane space chaperones for the highly insoluble carrier proteins.
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Cites
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Self-citationPROTEIN IMPORT INTO MITOCHONDRIA
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Cited by
A Disulfide Relay System in the Intermembrane Space of Mitochondria that Mediates Protein Import
Mesecke, N., Terziyska, N., Kozany, C., Baumann, F., Neupert, W., Hell, K., & Herrmann, J. M. (2005) · Cell · doi:10.1016/j.cell.2005.04.011 · Cited by 557
PNPASE Regulates RNA Import into Mitochondria
Wang, G., Chen, H.-W., Oktay, Y., Zhang, J., Allen, E. L., Smith, G. M., Fan, K. C., Hong, J. S., French, S. W., McCaffery, J. M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.035 · Cited by 366
Self-citationHuman deafness dystonia syndrome is a mitochondrial disease
Koehler, C. M., Leuenberger, D., Merchant, S., Renold, A., Junne, T., & Schatz, G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2141 · Cited by 337
Self-citationProtein Insertion into the Mitochondrial Inner Membrane by a Twin-Pore Translocase
Rehling, P., Model, K., Brandner, K., Kovermann, P., Sickmann, A., Meyer, H. E., Kühlbrandt, W., Wagner, R., Truscott, K. N., & Pfanner, N. (2003) · Science · doi:10.1126/science.1080945 · Cited by 332
Allen, S., Balabanidou, V., Sideris, D. P., Lisowsky, T., & Tokatlidis, K. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.08.049 · Cited by 235
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Metadata
- Authors
- Koehler, C. M., Jarosch, E., Tokatlidis, K., Schmid, K., Schweyen, R. J., & Schatz, G.
- Venue
- Science
- Published
- 1998-01-16
- Volume
- 279
- Issue
- 5349
- Pages
- 369-373
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2039492407
- Cited by
- 326
- References
- 21
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Koehler, C. M., Jarosch, E., Tokatlidis, K., Schmid, K., Schweyen, R. J., & Schatz, G. (1998). Import of Mitochondrial Carriers Mediated by Essential Proteins of the Intermembrane Space. Science. https://doi.org/10.1126/science.279.5349.369
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
