Cited by 500DNA Repair MechanismsEffects of Radiation ExposurePARP inhibition in cancer therapy

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

In Situ Visualization of DNA Double-Strand Break Repair in Human Fibroblasts

Nelms, Benjamin E., Maser, Richard S., MacKay, James F., Lagally, Max G., Petrini, John H. J.·1998·Science

Open this paper in CoChat — free account

Abstract

A method was developed to examine DNA repair within the intact cell. Ultrasoft x-rays were used to induce DNA double-strand breaks (DSBs) in defined subnuclear volumes of human fibroblasts and DNA repair was visualized at those sites. The DSBs remained in a fixed position during the initial stages of DNA repair, and the DSB repair protein hMre11 migrated to the sites of damage within 30 minutes. In contrast, hRad51, a human RecA homolog, did not localize at sites of DNA damage, a finding consistent with the distinct roles of these proteins in DNA repair.

Integrity signals

Registry

Crossref · 10.1126/science.280.5363.590

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The double-strand-break repair model for recombination
Szostak, J. W., Orr-Weaver, T. L., Rothstein, R. J., & Stahl, F. W. (1983) · Cell · doi:10.1016/0092-8674(83)90331-8 · Cited by 2,437
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900
DNA Strand Breaks: the DNA Template Alterations That Trigger p53-Dependent DNA Damage Response Pathways
Nelson, W. G., & Kastan, M. B. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1815 · Cited by 855
Human Rad51 Protein Promotes ATP-Dependent Homologous Pairing and Strand Transfer Reactions In Vitro
Baumann, P., Benson, F. E., & West, S. C. (1996) · Cell · doi:10.1016/s0092-8674(00)81394-x · Cited by 689
Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes.
Haaf, T., Golub, E. I., Reddy, G., Radding, C. M., & Ward, D. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.6.2298 · Cited by 552
DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA
Sung, P., & Robberson, D. L. (1995) · Cell · doi:10.1016/0092-8674(95)90434-4 · Cited by 501
hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †
Maser, R. S., Monsen, K. J., Nelms, B. E., & Petrini, J. H. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.10.6087 · Cited by 499
Self-citation
ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart
Shiloh, Y. (1997) · Annual Review of Genetics · doi:10.1146/annurev.genet.31.1.635 · Cited by 482
Visualization of replication factories attached to a nucleoskeleton
Hozák, P., Hassan, A. B., Jackson, D. A., & Cook, P. R. (1993) · Cell · doi:10.1016/0092-8674(93)90235-i · Cited by 466
Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest.
Huang, L. C., Clarkin, K. C., & Wahl, G. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4827 · Cited by 384

Flagged first, then by citations

Show all 38 references

Research works printed but not linked: 4

J. F. MacKay et al. Med. Phys. in press.
B. E. Nelms et al. Radiat. Res. in press.
R. P. Virsik-Peuckert in Radiation-Induced Chromosome Damage in Man I. Ishihara and M. S. Sasaki Eds. (Liss New York 1983) vol. 4 pp. 51–69.
E. L. Ivanov N. Sugawara C. I. White J. E. Haber ibid. 14 3414 (1994). · DOI

Sorted by citations

Items 101–200 of 499

Lessons learned from BRCA1 and BRCA2
Zheng, L., Li, S., Boyer, T., & Lee, W. (2000) · Oncogene · doi:10.1038/sj.onc.1203968 · Cited by 187
The Mammalian Mre11-Rad50-Nbs1 Protein Complex: Integration of Functions in the Cellular DNA–Damage Response
Petrini, J. H. J. (1999) · The American Journal of Human Genetics · doi:10.1086/302391 · Cited by 183
Self-citation
Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex
Grenon, M., Gilbert, C., & Lowndes, N. F. (2001) · Nature Cell Biology · doi:10.1038/ncb0901-844 · Cited by 184
Recruitment of Cellular Recombination and Repair Proteins to Sites of Herpes Simplex Virus Type 1 DNA Replication Is Dependent on the Composition of Viral Proteins within Prereplicative Sites and Correlates with the Induction of the DNA Damage Response
Wilkinson, D. E., & Weller, S. K. (2004) · Journal of Virology · doi:10.1128/jvi.78.9.4783-4796.2004 · Cited by 187
The Response to and Repair of RAG-Mediated DNA Double-Strand Breaks
Helmink, B. A., & Sleckman, B. P. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101320 · Cited by 199
Relationship between Expression of Bcl-2 Genes and Growth Factors in Ischemic Acute Renal Failure in the Rat
Gobe, G. C., Zhang, X., Willgoss, D. A., Schoch, E. M., Hogg, N., & Endre, Z. H. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v113454 · Cited by 183
NaCeF 4 :Gd,Tb Scintillator as an X-ray Responsive Photosensitizer for Multimodal Imaging-Guided Synchronous Radio/Radiodynamic Therapy
Zhong, X., Wang, X., Zhan, G., Tang, Y., Yao, Y., Dong, Z., Hou, L., Zhao, H., Zeng, S., Hu, J., et al. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b03682 · Cited by 183
Aprataxin, a novel protein that protects against genotoxic stress
Gueven, N. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh122 · Cited by 177
Checkpoint Failure and Chromosomal Instability without Lymphomagenesis in Mre11ATLD1/ATLD1 Mice
Theunissen, J.-W. F., Kaplan, M. I., Hunt, P. A., Williams, B. R., Ferguson, D. O., Alt, F. W., & Petrini, J. H. J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00455-6 · Cited by 173
Self-citation
Cellular radiosensitivity: How much better do we understand it?
Jeggo, P. A., & Lavin, M. F. (2009) · International Journal of Radiation Biology · doi:10.3109/09553000903261263 · Cited by 175
Werner helicase relocates into nuclear foci in response to DNA damaging agents and co‐localizes with RPA and Rad51
Sakamoto, S., Nishikawa, K., Heo, S., Goto, M., Furuichi, Y., & Shimamoto, A. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00433.x · Cited by 170
DNA Double-Strand Break Repair by Homologous Recombination
van den Bosch, M., Lohman, P. H. M., & Pastink, A. (2002) · Biological Chemistry · doi:10.1515/bc.2002.095 · Cited by 168
The Inherited Basis of Human Radiosensitivity
Gatti, R. A. (2001) · Acta Oncologica · doi:10.1080/02841860152619115 · Cited by 173
The biogenesis of chromosome translocations
Roukos, V., & Misteli, T. (2014) · Nature Cell Biology · doi:10.1038/ncb2941 · Cited by 174
Activation of multiple DNA repair pathways by sub-nuclear damage induction methods
Dinant, C., de Jager, M., Essers, J., van Cappellen, W. A., Kanaar, R., Houtsmuller, A. B., & Vermeulen, W. (2007) · Journal of Cell Science · doi:10.1242/jcs.004523 · Cited by 172
Biological Imaging of Heavy Charged-Particle Tracks
Jakob, B., Scholz, M., & Taucher-Scholz, G. (2003) · Radiation Research · doi:10.1667/0033-7587(2003)159[0676:biohct]2.0.co;2 · Cited by 156
C. elegans mre-11 is required for meiotic recombination and DNA repair but is dispensable for the meiotic G2 DNA damage checkpointPreprint
Chin, G. M., & Villeneuve, A. M. (2001) · Genes & Development · doi:10.1101/gad.864101 · Cited by 167
The Forkhead-associated Domain of NBS1 Is Essential for Nuclear Foci Formation after Irradiation but Not Essential for hRAD50·hMRE11·NBS1 Complex DNA Repair Activity
Tauchi, H., Kobayashi, J., Morishima, K.-I., Matsuura, S., Nakamura, A., Shiraishi, T., Ito, E., Masnada, D., Delia, D., & Komatsu, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000578200 · Cited by 156
Mechanisms that Promote and Suppress Chromosomal Translocations in Lymphocytes
Gostissa, M., Alt, F. W., & Chiarle, R. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101329 · Cited by 164
Association of Mre11p with Double-Strand Break Sites during Yeast Meiosis
Borde, V., Lin, W., Novikov, E. G., Petrini, J. H. J., Lichten, M., & Nicolas, A. G. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00034-6 · Cited by 143
Self-citation
Role for the BRCA1 C-terminal Repeats (BRCT) Protein 53BP1 in Maintaining Genomic Stability
Morales, J. C., Xia, Z., Lu, T., Aldrich, M. B., Wang, B., Rosales, C., Kellems, R. E., Hittelman, W. N., Elledge, S. J., & Carpenter, P. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212484200 · Cited by 142
Disruption of CNTNAP2 and additional structural genome changes in a boy with speech delay and autism spectrum disorder
Poot, M., Beyer, V., Schwaab, I., Damatova, N., van’t Slot, R., Prothero, J., Holder, S. E., & Haaf, T. (2010) · neurogenetics · doi:10.1007/s10048-009-0205-1 · Cited by 137
Chromatin dynamics during DSB repair
Falk, M., Lukášová, E., Gabrielova, B., Ondřej, V., & Kozubek, S. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.07.002 · Cited by 138
Review: ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia
Lavin, M. F. (1999) · International Journal of Radiation Biology · doi:10.1080/095530099139359 · Cited by 137
RAG-dependent primary immunodeficiencies
Sobacchi, C., Marrella, V., Rucci, F., Vezzoni, P., & VILLA, A. M. (2006) · Human Mutation · doi:10.1002/humu.20408 · Cited by 142
The contribution of homologous recombination in preserving genome integrity in mammalian cells
Thompson, L. H., & Schild, D. (1999) · Biochimie · doi:10.1016/s0300-9084(99)80042-x · Cited by 129
Higher-order chromatin structure in DSB induction, repair and misrepair
Falk, M., Lukášová, E., & Kozubek, S. (2010) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2010.01.013 · Cited by 137
Oxidative stress triggers the preferential assembly of base excision repair complexes on open chromatin regions
Amouroux, R., Campalans, A., Epe, B., & Radicella, J. P. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp1247 · Cited by 140
Regulation of E2F1 by BRCT Domain-Containing Protein TopBP1
Liu, K., Lin, F., Ruppert, J. M., & Lin, W.-C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.9.3287-3304.2003 · Cited by 132
Visualization of DNA double‐strand break repair in live bacteria reveals dynamic recruitment of Bacillus subtilis RecF, RecO and RecN proteins to distinct sites on the nucleoids
Kidane, D., Sánchez, H., Alonso, J. C., & Graumann, P. L. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04102.x · Cited by 130
Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen Breakage Syndrome 1.
Wu, G., Jiang, X., Lee, W., & Chen, P. (2003) · PubMed · Cited by 128
53BP1 exchanges slowly at the sites of DNA damage and appears to require RNA for its association with chromatin
Pryde, F. E., Khalili, S., Robertson, K., Selfridge, J., Ritchie, A., Melton, D. W., Jullien, D., & Adachi, Y. (2005) · Journal of Cell Science · doi:10.1242/jcs.02336 · Cited by 131
Human Cytomegalovirus Disrupts both Ataxia Telangiectasia Mutated Protein (ATM)- and ATM-Rad3-Related Kinase-Mediated DNA Damage Responses during Lytic Infection
Luo, M. H., Rosenke, K., Czornak, K., & Fortunato, E. A. (2006) · Journal of Virology · doi:10.1128/jvi.01670-06 · Cited by 129
Pathological and Physiological Double-Strand Breaks
Lieber, M. R. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65716-1 · Cited by 122
H2AX chromatin structures and their response to DNA damage revealed by 4Pi microscopy
Bewersdorf, J., Bennett, B. T., & Knight, K. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608709103 · Cited by 125
Dimerization, Translocation and Localization of Ku70 and Ku80 Proteins
Koike, M. (2002) · Journal of Radiation Research · doi:10.1269/jrr.43.223 · Cited by 119
Accurate in Vitro End Joining of a DNA Double Strand Break with Partially Cohesive 3′-Overhangs and 3′-Phosphoglycolate Termini
Chen, S., Inamdar, K. V., Pfeiffer, P., Feldmann, E., Hannah, M. F., Yu, Y., Lee, J.-W., Zhou, T., Lees‐Miller, S. P., & Povirk, L. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010544200 · Cited by 120
In situ visualization of ultraviolet-light-induced DNA damage repair in locally irradiated human fibroblasts
Katsumi, S., Kobayashi, N., Imoto, K., Nakagawa, A., Yamashina, Y., Muramatsu, T., Shirai, T., Miyagawa, S., Sugiura, S., Hanaoka, F., et al. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01540.x · Cited by 119
The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells
Li, L., Sharipo, A., Chaves‐Olarte, E., Masucci, M. G., Levitsky, V., Thelestam, M., & Frisan, T. (2002) · Cellular Microbiology · doi:10.1046/j.1462-5822.2002.00174.x · Cited by 119
The Nijmegen Breakage Syndrome Protein Is Essential for Mre11 Phosphorylation upon DNA Damage
Dong, Z., Zhong, Q., & Chen, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19513 · Cited by 123
Regulated Genomic Instability and Neoplasia in the Lymphoid Lineage
Vanasse, G. J., CONCANNON, P. J., & Willerford, D. M. (1999) · Blood · doi:10.1182/blood.v94.12.3997 · Cited by 114
Roles for Mismatch Repair Factors in Regulating Genetic Recombination
Evans, E., & Alani, E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.7839-7844.2000 · Cited by 112
Visualization of Chromatin Decompaction and Break Site Extrusion as Predicted by Statistical Polymer Modeling of Single-Locus Trajectories
Amitai, A., Seeber, A., Gasser, S. M., & Holcman, D. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.018 · Cited by 112
DNA lesions sequestered in micronuclei induce a local defective-damage response
Terradas, M., Martín, M., Tusell, L., & Genescà, A. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.07.004 · Cited by 110
A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues.
Krynetski, E. Y., Krynetskaia, N. F., Bianchi, M. E., & Evans, W. E. (2003) · PubMed · Cited by 108
Evidence for the Direct Binding of Phosphorylated p53 to Sites of DNA Breaks In vivo
Rashid, S. T. A., Dellaire, G., Cuddihy, A. R., Jalali, F., Vaid, M., Coackley, C. L., Folkard, M., Xu, Y., Chen, B. P. C., Chen, D. J., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0729 · Cited by 107
Mobility and immobility of chromatin in transcription and genome stability
Soutoglou, E., & Misteli, T. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2007.08.004 · Cited by 108
Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains
Jacobsen, E. A., Beach, T. G., Shen, Y., Li, R., & Chang, Y. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.05.023 · Cited by 105
The Pathogenesis of Ataxia-Telangiectasia
Gatti, R. A., Becker-Catania, S., Chun, H. H., Sun, X., Mitui, M., Lai, C.-H., Khanlou, N., Babaei, M., Cheng, R., Clark, C., et al. (2001) · Clinical Reviews in Allergy & Immunology · doi:10.1385/criai:20:1:87 · Cited by 101
The role of SMC proteins in the responses to DNA damage
Lehmann, A. R. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.07.009 · Cited by 101
Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process
Chung, D. K. C., Chan, J. N. Y., Strecker, J., Zhang, W., Ebrahimi‐Ardebili, S., Lu, T., Abraham, K. J., Durocher, D., & Mekhail, K. (2015) · Nature Communications · doi:10.1038/ncomms8742 · Cited by 106
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis
Jullien, D., Vagnarelli, P., Earnshaw, W. C., & Adachi, Y. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.1.71 · Cited by 100
A requirement for polymerized actin in DNA double-strand break repair
Andrin, C., McDonald, D., Attwood, K. M., Rodrigue, A., Ghosh, S., Mirzayans, R., Masson, J., Dellaire, G., & Hendzel, M. J. (2012) · Nucleus · doi:10.4161/nucl.21055 · Cited by 103
Telomere dysfunction in genome instability syndromes
Callén, E., & Surrallés, J. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2004.06.003 · Cited by 106
XRCC2 Is a Nuclear RAD51-like Protein Required for Damage-dependent RAD51 Focus Formation without the Need for ATP Binding
O’Regan, P., Wilson, C. R., Townsend, S., & Thacker, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102396200 · Cited by 99
Focus Formation of DNA Repair Proteins in Normal and Repair-Deficient Cells Irradiated with High-LET Ions
Karlsson, K. H., & Stenerlöw, B. (2004) · Radiation Research · doi:10.1667/rr3171 · Cited by 100
Imaging of protein movement induced by chromosomal breakage: tiny ‘local’ lesions pose great ‘global’ challenges
Lukas, C., Bártek, J., & Lukas, J. (2005) · Chromosoma · doi:10.1007/s00412-005-0011-y · Cited by 100
Radiation‐induced chromosome aberrations: Insights gained from biophysical modeling
Hlatky, L., Sachs, R. K., Vázquez, M., & Cornforth, M. N. (2002) · BioEssays · doi:10.1002/bies.10126 · Cited by 98
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks
Helmink, B. A., Bredemeyer, A. L., Lee, B.-S., Huang, C., Sharma, G. G., Walker, L. M., Bednarski, J. J., Lee, W.-L., Pandita, T. K., Bassing, C. H., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081326 · Cited by 103
The Saccharomyces cerevisiae Msh2 Mismatch Repair Protein Localizes to Recombination Intermediates In Vivo
Evans, E., Sugawara, N., Haber, J. E., & Alani, E. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80319-6 · Cited by 95
Coordinated response of mammalian Rad51 and Rad52 to DNA damage
Liu, Y., & Maizels, N. (2000) · EMBO Reports · doi:10.1093/embo-reports/kvd002 · Cited by 95
Retention but Not Recruitment of Crb2 at Double-Strand Breaks Requires Rad1 and Rad3 Complexes
Du, L.-L., Nakamura, T., Moser, B. A., & Russell, P. R. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.17.6150-6158.2003 · Cited by 94
Mutations in Mre11 Phosphoesterase Motif I That Impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 Complex Stability in Addition to Nuclease Activity
Krogh, B. O., Llorente, B., Lam, A. F., & Symington, L. S. (2005) · Genetics · doi:10.1534/genetics.105.049478 · Cited by 96
915 MHz microwaves and 50 Hz magnetic field affect chromatin conformation and 53BP1 foci in human lymphocytes from hypersensitive and healthy persons
Belyaev, I. Y., Hillert, L., Protopopova, M., Tamm, C., Malmgren, L. O. G., Persson, B., Selivanova, G., & Harms‐Ringdahl, M. (2005) · Bioelectromagnetics · doi:10.1002/bem.20103 · Cited by 92
Ion implantation of organisms
Feng, H. X., YU, Z., & Chu, P. K.-H. (2006) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2006.11.001 · Cited by 91
SV40 T antigen interacts with Nbs1 to disrupt DNA replication controlPreprint
Wu, X., Avni, D., Chiba, T., Feng, Y., Zhao, Q., Lin, Y., Heng, H. H., & Livingston, D. M. (2004) · Genes & Development · doi:10.1101/gad.1182804 · Cited by 90
Role of the Mre11 Complex in Preserving Genome Integrity
Oh, J., & Symington, L. S. (2018) · Genes · doi:10.3390/genes9120589 · Cited by 90
A Glycine-Arginine Domain in Control of the Human MRE11 DNA Repair Protein
Déry, U., Coulombe, Y., Rodrigue, A., Stasiak, A., Richard, S., & Masson, J. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02025-07 · Cited by 90
Repair of Laser-localized DNA Interstrand Cross-links in G1 Phase Mammalian Cells
Muniandy, P. A., Thapa, D., Thazhathveetil, A. K., Liu, S.-T., & Seidman, M. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.029025 · Cited by 86
Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM−/− and c-Abl−/− cells
Yuan, S. F., Chang, H.-L., & Lee, E. Y.-H. P. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(03)00009-5 · Cited by 87
Dynamic formation of RecA filaments at DNA double strand break repair centers in live cells
Kidane, D., & Graumann, P. L. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412090 · Cited by 85
Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia
Digweed, M. (2002) · Carcinogenesis · doi:10.1093/carcin/23.7.1121 · Cited by 87
Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs
Thapar, R. (2018) · Molecules · doi:10.3390/molecules23112789 · Cited by 86
The Mre11-Rad50-Nbs1 Complex Acts Both Upstream and Downstream of Ataxia Telangiectasia Mutated and Rad3-related Protein (ATR) to Regulate the S-phase Checkpoint following UV Treatment
Olson, E. E., Nievera, C. J., Lee, A. Y., Chen, L., & Wu, X. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702162200 · Cited by 86
NF-κB activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage
Wuerzberger‐Davis, S. M., Nakamura, Y., Seufzer, B. J., & Miyamoto, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209815 · Cited by 82
The Mre11 Complex Mediates the S-Phase Checkpoint through an Interaction with Replication Protein A
Olson, E. E., Nievera, C. J., Liu, E., Lee, A. Y., Chen, L., & Wu, X. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00532-07 · Cited by 83
DNA damage repair and genetic polymorphisms: Assessment of individual sensitivity and repair capacity
Cornetta, T., Festa, F., Testa, A., & Cozzi, R. (2006) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2006.06.037 · Cited by 80
Probing Single Molecules in Single Living Cells
Byassee, T. A., Chan, W. C. W., & Nie, S. (2000) · Analytical Chemistry · doi:10.1021/ac000705j · Cited by 79
ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining
Rahal, E. A., Henricksen, L. A., Li, Y., Williams, R. S., Tainer, J. A., & Dixon, K. (2010) · Cell Cycle · doi:10.4161/cc.9.14.12363 · Cited by 78
A role for Brca1 in chromosome end maintenance
McPherson, J. P., Hande, M. P., Poonepalli, A., Lemmers, B., Matysiak‐Zablocki, E., Migon, E., Shehabeldin, A., Porras, A., Karásková, J., Vukovic, B., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl002 · Cited by 79
Positional Stability of Damaged Chromatin Domains along Radiation Tracks in Mammalian Cells
Jakob, B., Splinter, J., & Taucher-Scholz, G. (2009) · Radiation Research · doi:10.1667/rr1520.1 · Cited by 81
The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks
Lavin, M. F. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.07.001 · Cited by 82
Cell and tissue responses to genotoxic stress
Coates, P. J., Lorimore, S. A., & Wright, E. G. (2005) · The Journal of Pathology · doi:10.1002/path.1701 · Cited by 77
PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation
Deng, R., Tang, J., Ma, J.-G., Chen, S.-P., Xia, L.-P., Zhou, W.-J., Li, D., Feng, G.-K., Zeng, Y.-X., & Zhu, X.-F. (2010) · Oncogene · doi:10.1038/onc.2010.467 · Cited by 77
hMRE11: genomic structure and a null mutation identified in a transcript protected from nonsense-mediated mRNA decay
Pitts, S. A. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.11.1155 · Cited by 75
Nibrin Forkhead-associated Domain and Breast Cancer C-terminal Domain Are Both Required for Nuclear Focus Formation and Phosphorylation
Cerosaletti, K. M., & Concannon, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211689200 · Cited by 74
Homologous recombinational repair proteins in mouse meiosis
Bannister, L., & Schimenti, J. C. (2004) · Cytogenetic and Genome Research · doi:10.1159/000080597 · Cited by 74
Two recombination-dependent DNA replication pathways of bacteriophage T4, and their roles in mutagenesis and horizontal gene transfer
Mosig, G., Gewin, J., Luder, A., Colowick, N. E., & Vo, D. X. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131007398 · Cited by 72
The importance of XRCC2 in RAD51-related DNA damage repair
Tambini, C. E., Spink, K. G., Ross, C. J., Hill, M. A., & Thacker, J. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.01.016 · Cited by 71
Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses
Zhao, S. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf612 · Cited by 72
Cell Cycle-dependent Regulation of a Human DNA Helicase That Localizes in DNA Damage Foci
Gu, J., Xia, X., Yan, P., Liu, H., Podust, V. N., Reynolds, A. B., & Fanning, E. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-03-0227 · Cited by 70
Localization and dynamic relocalization of mammalian Rad52 during the cell cycle and in response to DNA damage
Liu, Y., Li, M.-J., Lee, E. Y.-H. P., & Maizels, N. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80427-8 · Cited by 70
An anticlastogenic function for the Polycomb Group gene Bmi1
Chagraoui, J., Hébert, J., Girard, S., & Sauvageau, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014263108 · Cited by 73
Analysis of ionizing radiation-induced foci of DNA damage repair proteins
van Veelen, L. R., Cervelli, T., van de Rakt, M. W. M. M., Theil, A. F., Essers, J., & Kanaar, R. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.01.019 · Cited by 71
Chromosome territories reposition during DNA damage-repair response
Mehta, I. S., Kulashreshtha, M., Chakraborty, S., Kolthur‐Seetharam, U., & Rao, B. J. (2013) · Genome biology · doi:10.1186/gb-2013-14-12-r135 · Cited by 71
Chromosomal breakage syndromes
Carney, J. P. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)80074-0 · Cited by 68
UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles
Campalans, A., Amouroux, R., Bravard, A., Epe, B., & Radicella, J. P. (2006) · Journal of Cell Science · doi:10.1242/jcs.03312 · Cited by 67
Four radiation hypersensitivity cases and their implications for clinical radiotherapy
Rogers, P. B., Plowman, P. N., Harris, S., & Arlett, C. F. (2000) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(00)00249-8 · Cited by 73
DNA damage repair: anytime, anywhere?
Essers, J., Vermeulen, W., & Houtsmuller, A. B. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.03.004 · Cited by 67
Medulloblastoma With Adverse Reaction to Radiation Therapy in Nijmegen Breakage Syndrome
Bakhshi, S., Cerosaletti, K. M., CONCANNON, P. J., Bawle, E. V., Fontanesi, J., Gatti, R. A., & Bhambhani, K. J. (2003) · Journal of Pediatric Hematology/Oncology · doi:10.1097/00043426-200303000-00013 · Cited by 69

Authors: Nelms, B. E., Maser, R. S., MacKay, J. F., Lagally, M. G., & Petrini, J. H. J.
Affiliations: University of Wisconsin System (US)
Corresponding author: Nelms, Benjamin E.
Maser, Richard S.
Petrini, John H. J.
ORCID: Petrini, John H. J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-04-24
Volume: 280
Issue: 5363
Pages: 590-592
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.280.5363.590
OpenAlex: W2054889035
Cited by: 500
References: 38
Citations by year: 2025: 1 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 10 · 2019: 3 · 2018: 11 · 2017: 7 · 2016: 13 · 2015: 5 · 2014: 21 · 2013: 16 · 2012: 13
FWCI: 12.98
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (T32GM008349, T32GM007133)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: DNA double-strand break repair, human fibroblasts, in situ visualization, ultrasoft X-rays, RecA homolog, subnuclear localization, DNA damage response, protein localization
MeSH terms: Bromodeoxyuridine, Cell Line, Cell Nucleus, DNA, DNA Damage, DNA Repair, DNA-Binding Proteins, Fibroblasts, Fluorescent Antibody Technique, Humans, Fluorescein-5-isothiocyanate, Microscopy, Confocal, Rad51 Recombinase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

In Situ Visualization of DNA Double-Strand Break Repair in Human Fibroblasts

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks