Cited by 500DNA Repair MechanismsEffects of Radiation ExposurePARP inhibition in cancer therapy

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In Situ Visualization of DNA Double-Strand Break Repair in Human Fibroblasts

Nelms, Benjamin E., Maser, Richard S., MacKay, James F., Lagally, Max G., Petrini, John H. J.·1998·Science

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Abstract

A method was developed to examine DNA repair within the intact cell. Ultrasoft x-rays were used to induce DNA double-strand breaks (DSBs) in defined subnuclear volumes of human fibroblasts and DNA repair was visualized at those sites. The DSBs remained in a fixed position during the initial stages of DNA repair, and the DSB repair protein hMre11 migrated to the sites of damage within 30 minutes. In contrast, hRad51, a human RecA homolog, did not localize at sites of DNA damage, a finding consistent with the distinct roles of these proteins in DNA repair.

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Authors: Nelms, B. E., Maser, R. S., MacKay, J. F., Lagally, M. G., & Petrini, J. H. J.
Affiliations: University of Wisconsin System (US)
Corresponding author: Nelms, Benjamin E.
Maser, Richard S.
Petrini, John H. J.
ORCID: Petrini, John H. J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-04-24
Volume: 280
Issue: 5363
Pages: 590-592
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.280.5363.590
OpenAlex: W2054889035
Cited by: 500
References: 38
Citations by year: 2025: 1 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 10 · 2019: 3 · 2018: 11 · 2017: 7 · 2016: 13 · 2015: 5 · 2014: 21 · 2013: 16 · 2012: 13
FWCI: 12.98
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (T32GM008349, T32GM007133)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: DNA double-strand break repair, human fibroblasts, in situ visualization, ultrasoft X-rays, RecA homolog, subnuclear localization, DNA damage response, protein localization
MeSH terms: Bromodeoxyuridine, Cell Line, Cell Nucleus, DNA, DNA Damage, DNA Repair, DNA-Binding Proteins, Fibroblasts, Fluorescent Antibody Technique, Humans, Fluorescein-5-isothiocyanate, Microscopy, Confocal, Rad51 Recombinase

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In Situ Visualization of DNA Double-Strand Break Repair in Human Fibroblasts

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