In Situ Visualization of DNA Double-Strand Break Repair in Human Fibroblasts

The double-strand-break repair model for recombination

Szostak, J. W., Orr-Weaver, T. L., Rothstein, R. J., & Stahl, F. W. (1983) · Cell · doi:10.1016/0092-8674(83)90331-8 · Cited by 2,437

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900

DNA Strand Breaks: the DNA Template Alterations That Trigger p53-Dependent DNA Damage Response Pathways

Nelson, W. G., & Kastan, M. B. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1815 · Cited by 855

Human Rad51 Protein Promotes ATP-Dependent Homologous Pairing and Strand Transfer Reactions In Vitro

Baumann, P., Benson, F. E., & West, S. C. (1996) · Cell · doi:10.1016/s0092-8674(00)81394-x · Cited by 689

Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes.

Haaf, T., Golub, E. I., Reddy, G., Radding, C. M., & Ward, D. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.6.2298 · Cited by 552

DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA

Sung, P., & Robberson, D. L. (1995) · Cell · doi:10.1016/0092-8674(95)90434-4 · Cited by 501

hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

Maser, R. S., Monsen, K. J., Nelms, B. E., & Petrini, J. H. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.10.6087 · Cited by 499

ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart

Shiloh, Y. (1997) · Annual Review of Genetics · doi:10.1146/annurev.genet.31.1.635 · Cited by 482

Visualization of replication factories attached to a nucleoskeleton

Hozák, P., Hassan, A. B., Jackson, D. A., & Cook, P. R. (1993) · Cell · doi:10.1016/0092-8674(93)90235-i · Cited by 466

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest.

Huang, L. C., Clarkin, K. C., & Wahl, G. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4827 · Cited by 384

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

Rogakou, E. P., Boon, C., Redon, C., & Bonner, W. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.5.905 · Cited by 2,422

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., & Bonner, W. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00610-2 · Cited by 2,098

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966

Spatial and temporal expression of short, long/medium or both opsins in human fetal cones

Xiao (2000) · doi:10.1002/1096-9861(20001002)425:4

DNA Damage Foci at Dysfunctional Telomeres

Takai, H., Smogorzewska, A., & de Lange, T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00542-6 · Cited by 1,409

Sensing and repairing DNA double-strand breaks

Jackson, S. P. (2002) · Carcinogenesis · doi:10.1093/carcin/23.5.687 · Cited by 1,149

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

Polo, S. E., & Jackson, S. P. (2011) · Genes & Development · doi:10.1101/gad.2021311 · Cited by 1,092

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060

Involvement of the TIP60 Histone Acetylase Complex in DNA Repair and Apoptosis

Ikura, T., Ogryzko, V. V., Grigoriev, M., Groisman, R., Wang, J., Horikoshi, M., Scully, R., Qin, J., & Nakatani, Y. (2000) · Cell · doi:10.1016/s0092-8674(00)00051-9 · Cited by 1,029

H2AX: the histone guardian of the genome

Fernández-Capetillo, Ó., Lee, A., Nussenzweig, M. C., & Nussenzweig, A. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.024 · Cited by 1,031

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

Mimitou, E. P., & Symington, L. S. (2008) · Nature · doi:10.1038/nature07312 · Cited by 1,060

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

Celeste, A., Fernandez-Capetillo, O., Kruhlak, M. J., Pilch, D. R., Staudt, D. W., Lee, A., Bonner, R. F., Bonner, W. M., & Nussenzweig, A. (2003) · Nature Cell Biology · doi:10.1038/ncb1004 · Cited by 989

Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair

Symington, L. S. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.4.630-670.2002 · Cited by 989

P53 Binding Protein 1 (53bp1) Is an Early Participant in the Cellular Response to DNA Double-Strand Breaks

Schultz, L. B., Chehab, N. H., Malikzay, A., & Halazonetis, T. D. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.7.1381 · Cited by 916

Choreography of the DNA Damage Response

Lisby, M., Barlow, J. H., Burgess, R. C., & Rothstein, R. (2004) · Cell · doi:10.1016/j.cell.2004.08.015 · Cited by 891

The DNA-dependent protein kinasePreprint

Smith, G. C. M., & Jackson, S. P. (1999) · Genes & Development · doi:10.1101/gad.13.8.916 · Cited by 903

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T. K., Hampton, G. M., & Wahl, G. M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00520-8 · Cited by 876

The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling

D'Amours, D., & Jackson, S. P. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm805 · Cited by 874

DNA Double-Strand Break Repair: All's Well that Ends Well

Wyman, C., & Kanaar, R. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090451 · Cited by 830

DNA damage responses to oxidative stress

Barzilai, A., & Yamamoto, K.-I. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.002 · Cited by 796

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

Lim, D.-S., Kim, S.-T., Xu, B., Maser, R. S., Lin, J., Petrini, J. H. J., & Kastan, M. B. (2000) · Nature · doi:10.1038/35007091 · Cited by 786

V(D)J Recombination: RAG Proteins, Repair Factors, and Regulation

Gellert, M. F. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.150203 · Cited by 771

Nano-Flares: Probes for Transfection and mRNA Detection in Living Cells

Seferos, D. S., Giljohann, D. A., Hill, H. D., Prigodich, A. E., & Mirkin, C. A. (2007) · Journal of the American Chemical Society · doi:10.1021/ja0776529 · Cited by 711

Interfaces Between the Detection, Signaling, and Repair of DNA Damage

Rouse, J. W., & Jackson, S. P. (2002) · Science · doi:10.1126/science.1074740 · Cited by 696

Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response

Zhong, Q., Chen, C.-F., Li, S., Chen, Y., Wang, C.-C., Xiao, J., Chen, P.-L., Sharp, Z. D., & Lee, W.-H. (1999) · Science · doi:10.1126/science.285.5428.747 · Cited by 626

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

Zhu, X., Küster, B., Mann, M., Petrini, J. H. J., & de Lange, T. (2000) · Nature Genetics · doi:10.1038/77139 · Cited by 619

Mechanisms of human DNA repair: an update

Christmann, M., Tomicic, M. T., Roos, W. P., & Kaina, B. (2003) · Toxicology · doi:10.1016/s0300-483x(03)00287-7 · Cited by 599

Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer

Lin, C., Yang, L., Tanasa, B., Hutt, K., Ju, B.-G., Ohgi, K. A., Zhang, J., Rose, D. W., Fu, X.-D., Glass, C. K., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.030 · Cited by 576

Regulation and mechanisms of mammalian double-strand break repair

Valerie, K. C., & Povirk, L. F. (2003) · Oncogene · doi:10.1038/sj.onc.1206679 · Cited by 594

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

Paull, T. T., & Gellert, M. (1999) · Genes & Development · doi:10.1101/gad.13.10.1276 · Cited by 551

DNA Ligase IV Mutations Identified in Patients Exhibiting Developmental Delay and Immunodeficiency

O’Driscoll, M., Cerosaletti, K. M., Girard, P.-M., Dai, Y., Stümm, M., Kysela, B. P., Hirsch, B. A., Gennery, A. R., Palmer, S. E., Seidel, J., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00408-7 · Cited by 565

Molecular mechanisms of DNA double-strand break repair

Kanaar, R., Hoeijmakers, J. H. J., & van Gent, D. C. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01383-x · Cited by 527

Adenovirus oncoproteins inactivate the Mre11–Rad50–NBS1 DNA repair complex

Stracker, T. H., Carson, C. T., & Weitzman, M. D. (2002) · Nature · doi:10.1038/nature00863 · Cited by 522

Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

Kruhlak, M. J., Celeste, A., Dellaire, G., Fernandez-Capetillo, O., Müller, W. G., McNally, J. G., Bazett-Jones, D. P., & Nussenzweig, A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200510015 · Cited by 518

Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease

Lovell, M. A., & Markesbery, W. R. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm821 · Cited by 515

Positional stability of single double-strand breaks in mammalian cells

Soutoglou, E., Dorn, J. F., Sengupta, K., Jasin, M., Nussenzweig, A., Ried, T., Danuser, G., & Misteli, T. (2007) · Nature Cell Biology · doi:10.1038/ncb1591 · Cited by 509

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpointPreprint

Yazdi, P. T., Wang, Y., Zhao, S., Patel, N., Lee, E. Y.-H. P., & Qin, J. (2002) · Genes & Development · doi:10.1101/gad.970702 · Cited by 519

Distribution and Dynamics of Chromatin Modification Induced by a Defined DNA Double-Strand Break

Shroff, R., Arbel‐Eden, A., Pilch, D. R., Ira, G., Bonner, W. M., Petrini, J. H. J., Haber, J. E., & Lichten, M. (2004) · Current Biology · doi:10.1016/j.cub.2004.09.047 · Cited by 524

The Mre11 complex is required for ATM activation and the G2/M checkpoint

Carson, C. T., Schwartz, R. A., Stracker, T. H., Lilley, C. E., Lee, D. V., & Weitzman, M. D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg630 · Cited by 502

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatinPreprint

Zou, L., Cortez, D., & Elledge, S. J. (2002) · Genes & Development · doi:10.1101/gad.950302 · Cited by 498

Dynamics of DNA Double-Strand Breaks Revealed by Clustering of Damaged Chromosome Domains

Aten, J. A., Stap, J., Krawczyk, P. M., van Oven, C. H., Hoebe, R. A., Essers, J., & Kanaar, R. (2004) · Science · doi:10.1126/science.1088845 · Cited by 491

DNA Damage ResponsePreprint

Giglia‐Mari, G., Zotter, A., & Vermeulen, W. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000745 · Cited by 525

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

Zhao, S., Weng, Y., Yuan, S. F., Lin, Y.-T., Hsu, H.-C., Lin, S. J., Gerbino, E., Song, M., Zdzienicka, M. Z., Gatti, R. A., et al. (2000) · Nature · doi:10.1038/35013083 · Cited by 491

The emerging role of nuclear architecture in DNA repair and genome maintenance

Misteli, T., & Soutoglou, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2651 · Cited by 501

ATM-dependent phosphorylation of nibrin in response to radiation exposure

Gatei, M., Young, D., Cerosaletti, K. M., Desai-Mehta, A., Spring, K., Kozlov, S., Lavin, M. F., Gatti, R. A., Concannon, P., & Khanna, K. (2000) · Nature Genetics · doi:10.1038/75508 · Cited by 468

The MRN complex in double‐strand break repair and telomere maintenance

Lamarche, B. J., Orazio, N. I., & Weitzman, M. D. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.07.029 · Cited by 446

The Nuclease Activity of Mre11 Is Required for Meiosis but Not for Mating Type Switching, End Joining, or Telomere Maintenance

Moreau, S., Ferguson, J. R., & Symington, L. S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.556 · Cited by 447

Homologous recombinational repair of DNA ensures mammalian chromosome stability

Thompson, L. H., & Schild, D. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00115-4 · Cited by 435

The FHA domain

Durocher, D., & Jackson, S. P. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03294-x · Cited by 425

DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

Dasika, G. K., Lin, S.-C. J., Zhao, S., Sung, P., Tomkinson, A., & Lee, E. Y.-H. P. (1999) · Oncogene · doi:10.1038/sj.onc.1203283 · Cited by 427

Recombinational DNA repair and human disease

Thompson, L. H., & Schild, D. (2002) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(02)00224-5 · Cited by 417

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

Luo, G., Yao, M. S., Bender, C. F., Mills, M., Bladl, A. R., Bradley, A., & Petrini, J. H. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7376 · Cited by 415

The Many Interfaces of Mre11

Haber, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81626-8 · Cited by 406

DNA Damage-Dependent Nuclear Dynamics of the Mre11 Complex

Mirzoeva, O. K., & Petrini, J. H. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.281-288.2001 · Cited by 387

A DNA Damage Response Pathway Controlled by Tel1 and the Mre11 Complex

Usui, T., Ogawa, H., & Petrini, J. H. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00270-2 · Cited by 384

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice

Zhu, J., Petersen, S., Tessarollo, L., & Nussenzweig, A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00019-7 · Cited by 385

Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage

Anderson, L., Henderson, C., & Adachi, Y. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.5.1719-1729.2001 · Cited by 367

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography

Thompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357

Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage

Raderschall, E., Golub, E. I., & Haaf, T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.1921 · Cited by 350

The cellular response to DNA double-strand breaks: defining the sensors and mediators

Petrini, J. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00170-3 · Cited by 339

Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery

Dion, V., Kalck, V., Horigome, C., Towbin, B. D., & Gasser, S. M. (2012) · Nature Cell Biology · doi:10.1038/ncb2465 · Cited by 337

Spatial Dynamics of Chromosome Translocations in Living Cells

Roukos, V., Voss, T. C., Schmidt, C. K., Lee, S., Wangsa, D., & Misteli, T. (2013) · Science · doi:10.1126/science.1237150 · Cited by 331

Response to RAG-Mediated V(D)J Cleavage by NBS1 and γ-H2AX

Chen, H. T., Bhandoola, A., Difilippantonio, M. J., Zhu, J., Brown, M. J., Tai, X., Rogakou, E. P., Brotz, T. M., Bonner, W. M., Ried, T., et al. (2000) · Science · doi:10.1126/science.290.5498.1962 · Cited by 326

Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences

Dudley, D. D., Chaudhuri, J., Bassing, C. H., & Alt, F. W. (2005) · Advances in immunology · doi:10.1016/s0065-2776(04)86002-4 · Cited by 347

Promotion of Dnl4-Catalyzed DNA End-Joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 Complexes

Chen, L., Trujillo, K. M., Ramos, W., Sung, P., & Tomkinson, A. E. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00388-4 · Cited by 316

Zip3 Provides a Link between Recombination Enzymes and Synaptonemal Complex Proteins

Agarwal, S., & Roeder, G. S. (2000) · Cell · doi:10.1016/s0092-8674(00)00029-5 · Cited by 302

ATM: Genome stability, neuronal development, and cancer cross paths

(2001) · Advances in Cancer Research · doi:10.1016/s0065-230x(01)83007-4 · Cited by 299

Association of DNA Polymerase μ (pol μ) with Ku and Ligase IV: Role for pol μ in End-Joining Double-Strand Break Repair

Mahajan, K. N., Nick McElhinny, S. A., Mitchell, B. S., & Ramsden, D. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5194-5202.2002 · Cited by 293

The MRN complex: coordinating and mediating the response to broken chromosomes

van den Bosch, M., Bree, R. T., & Lowndes, N. F. (2003) · The EMBO Reports · doi:10.1038/sj.embor.embor925 · Cited by 289

End Resection at Double-Strand Breaks: Mechanism and RegulationPreprint

Symington, L. S. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016436 · Cited by 307

Nuclear Retention of ATM at Sites of DNA Double Strand Breaks

Andegeko, Y., Moyal, L., Rotman, G., Shiloh, Y., Mittelman, L., & Tsarfaty, I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102986200 · Cited by 276

DNA Damage Response: Three Levels of DNA Repair Regulation

Sirbu, B. M., & Cortez, D. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012724 · Cited by 272

DNA double-strand break repair by homologous recombination

Dudáš, A., & Chovanec, M. (2003) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.07.001 · Cited by 283

Ataxia-telangiectasia-like disorder (ATLD)?its clinical presentation and molecular basis

Taylor, A. M. R., Groom, A., & Byrd, P. J. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.04.009 · Cited by 277

ATM, a central controller of cellular responses to DNA damage

Khanna, K. K., Lavin, M. F., Jackson, S. P., & Mulhern, T. D. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400874 · Cited by 260

Specific Recruitment of Human Cohesin to Laser-induced DNA Damage

Kim, J.-S., Krasieva, T. B., LaMorte, V. J., Taylor, A. M. R., & Yokomori, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209123200 · Cited by 257

An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage

Heffernan, T. P., Simpson, D. A., Frank, A. R., Heinloth, A. N., Paules, R. S., Cordeiro-Stone, M., & Kaufmann, W. K. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8552-8561.2002 · Cited by 251

Genomic integrity and the repair of double-strand DNA breaks

Pastink, A., Eeken, J. C. J., & Lohman, P. H. M. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00167-1 · Cited by 247

Xrcc3 Is Required for Assembly of Rad51 Complexes in Vivo

Bishop, D. K., Ear, U., Bhattacharyya, A., Calderone, C., Beckett, M., Weichselbaum, R. R., & Shinohara, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.34.21482 · Cited by 247

Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis

Goedecke, W., Eijpe, M., Offenberg, H. H., van Aalderen, M., & Heyting, C. (1999) · Nature Genetics · doi:10.1038/13821 · Cited by 235

Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint controlPreprint

Boisvert, F., Déry, U., Masson, J., & Richard, S. (2005) · Genes & Development · doi:10.1101/gad.1279805 · Cited by 241

The Mre11 complex and ATM: collaborating to navigate S phase

Petrini, J. H. J. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00091-0 · Cited by 233

Chromatin Movement in the Maintenance of Genome Stability

Dion, V., & Gasser, S. M. (2013) · Cell · doi:10.1016/j.cell.2013.02.010 · Cited by 241

Higher-order Genome Organization in Human DiseasePreprint

Misteli, T. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000794 · Cited by 223

Cancer predisposition and hematopoietic failure in Rad50 S/S mice

Bender, C. F., Sikes, M. L., Sullivan, R., Huye, L. E., Le Beau, M. M., Roth, D. B., Mirzoeva, O. K., Oltz, E. M., & Petrini, J. H. J. (2002) · Genes & Development · doi:10.1101/gad.1007902 · Cited by 213

Spatial genome organization in the formation of chromosomal translocations

Meaburn, K. J., Misteli, T., & Soutoglou, E. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.10.008 · Cited by 223

Mre11 Complex and DNA Replication: Linkage to E2F and Sites of DNA Synthesis

Maser, R. S., Mirzoeva, O. K., Wells, J. M., Olivares, H. A., Williams, B. R., Zinkel, R. A., Farnham, P., & Petrini, J. H. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.6006-6016.2001 · Cited by 215

UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, γ-H2AX formation, and Mre11 relocalization

Limoli, C. L., Giedzinski, E., Bonner, W. M., & Cleaver, J. E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231611798 · Cited by 210

The Role of the BRCA1 Tumor Suppressor in DNA Double-Strand Break Repair

Zhang, J., & Powell, S. N. (2005) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0192 · Cited by 213

ATM signaling and genomic stability in response to DNA damage

Lavin, M. F., Birrell, G. W., Chen, P., Kozlov, S., Scott, S. P., & Gueven, N. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.04.020 · Cited by 208

Rad51 Accumulation at Sites of DNA Damage and in Postreplicative Chromatin

Tashiro, S., Walter, J. K., Shinohara, A., Kamada, N., & Cremer, T. J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.2.283 · Cited by 208

Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization

Costes, S. V., Chiolo, I., Pluth, J. M., Barcellos‐Hoff, M. H., & Jakob, B. (2010) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2009.12.006 · Cited by 213

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A Review of Studies of Ionizing Radiation-Induced Double-Strand Break Clustering

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Live cell microscopy analysis of radiation-induced DNA double-strand break motion

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RPA2 Is a Direct Downstream Target for ATR to Regulate the S-phase Checkpoint

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DNA replication-dependent nuclear dynamics of the Mre11 complex.

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Human MRE11 is inactivated in mismatch repair‐deficient cancers

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hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

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Dynamics of DNA-repair factors and chromosomes studied by laser-UVA-microirradiation and laser-photobleaching

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In situ visualization of ultraviolet-light-induced DNA damage repair in locally irradiated human fibroblasts

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Rad51 Accumulation at Sites of DNA Damage and in

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Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage

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