The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
The Biology of Being Frazzled
Abstract
Under stress, our brain works differently. From our own experiences we know this, but now several lines of research are defining the neurobiology behind these changes. In her commentary, Arnsten summarizes recent work that demonstrates that some kinds of memory become enhanced (such as the image of a gruesome accident), while higher order thinking, mediated by a region of the brain called the prefrontal cortex, becomes impaired.
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In the citing paper
“We now understand that the types of tasks that were impaired by stress were those that required PFC operations13, whereas engrained habits that rely on basal ganglia circuits were spared or enhanced14.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [13]
In the citing paper
“Exposure to an acute, uncontrollable stress impairs the performance of PFC cognitive tasks in rodents, monkeys and humans25.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [25]
In the citing paper
“adolescents seem particularly prone to have their decision-making influenced by exciting, emotionally charged and/or stressful situations”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Arnsten, 1998
In the citing paper
“adolescents seem particularly prone to have their decision-making influenced by exciting, emotionally charged and/or stressful situations (so called “hot cognitions” – e.g., Arnsten, 1998; Dahl, 2001; Figner et al, 2009).”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Arnsten, 1998
In the citing paper
“stressors tending to increase activation in the ventral striatum, amygdala and other subcortical regions such as the hippocampus, while attenuating functional efficacy within the PFC (Arnsten, 1998, Liston et al, 2009)”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Arnsten, 1998
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Metadata
- Authors
- Arnsten, A. F. T.
- Affiliations
- Yale University (US)
- Corresponding author
- Arnsten, Amy F. T.
- ORCID
- Arnsten, Amy F. T.
- Venue
- Science
- Published
- 1998-06-12
- Volume
- 280
- Issue
- 5370
- Pages
- 1711-1712
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1572413306
- Cited by
- 341
- References
- 16
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 10 · 2022: 18 · 2021: 9 · 2020: 14 · 2019: 19 · 2018: 11 · 2017: 12 · 2016: 20 · 2015: 16 · 2014: 13 · 2013: 20 · 2012: 19
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- stress, neurobiology of stress, memory enhancement, prefrontal cortex, cognitive impairment, emotional memory, stress hormones
- MeSH terms
- Amygdala, Animals, Attention, Mental Disorders, Catecholamines, Dopamine, Humans, Memory, Norepinephrine, Receptors, Adrenergic, beta, Stress, Physiological, Prefrontal Cortex, Receptors, Dopamine D1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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