Cited by 2,803Cancer-related Molecular PathwaysDNA Repair MechanismsMicrotubule and mitosis dynamics

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Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage

Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., Vogelstein, B.·1998·Science

DOI 10.1126/science.282.5393.1497

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Abstract

After DNA damage, many cells appear to enter a sustained arrest in the G 2 phase of the cell cycle. It is shown here that this arrest could be sustained only when p53 was present in the cell and capable of transcriptionally activating the cyclin-dependent kinase inhibitor p21. After disruption of either the p53 or the p21 gene, γ radiated cells progressed into mitosis and exhibited a G 2 DNA content only because of a failure of cytokinesis. Thus, p53 and p21 appear to be essential for maintaining the G 2 checkpoint in human cells.

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p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693
Participation of p53 protein in the cellular response to DNA damage.
Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761
Self-citation
p21 is a universal inhibitor of cyclin kinases
Xiong, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R., & Beach, D. (1993) · Nature · doi:10.1038/366701a0 · Cited by 3,691
Universal control mechanism regulating onset of M-phase
Nurse, P. (1990) · Nature · doi:10.1038/344503a0 · Cited by 2,798
Cell Cycle Control and Cancer
Hartwell, L. H., & Kastan, M. B. (1994) · Science · doi:10.1126/science.7997877 · Cited by 2,539
p53: puzzle and paradigm.Preprint
Ko, L. J., & Prives, C. L. (1996) · Genes & Development · doi:10.1101/gad.10.9.1054 · Cited by 2,346
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P. (1995) · Cell · doi:10.1016/0092-8674(95)90039-x · Cited by 2,113
Mutations of mitotic checkpoint genes in human cancers
Cahill, D. P., Lengauer, C., Yu, J., Riggins, G. J., Willson, J. K. V., Markowitz, S. D., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/32688 · Cited by 1,490
Self-citation
Mitotic and G 2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216
Peng, C.-Y., Graves, P. R., Thoma, R. S., Wu, Z., Shaw, A. S., & Piwnica-Worms, H. (1997) · Science · doi:10.1126/science.277.5331.1501 · Cited by 1,341
Is a p53-Regulated Inhibitor of G2/M Progression
Hermeking, H., Lengauer, C., Polyak, K., He, T.-C., Zhang, L., Thiagalingam, S., Kinzler, K. W., & Vogelstein, B. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80002-7 · Cited by 1,251
Self-citation

Show all 50 references

Research works printed but not linked: 13

Kastan M. B., Onyekwere O., Sidransky D., Vogelstein B., Craig R. W., Cancer Res. 51, 6304 (1991);
Waldman T., Kinzler K. W., Vogelstein B., Cancer Res. 55, 5187 (1995).
Powell S. N., et al., Cancer Res. 55, 1643 (1995);
Fan S., et al., Cancer Res. 55, 1649 (1995);
Russell K. J., et al., ibid. 55, 1639 (1995).
Khan S. H., Wahl G. M., Cancer Res. 58, 396 (1998);
Michieli P., et al., Cancer Res. 54, 3391 (1994);
Paules R. S., et al., Cancer Res 55, 1763 (1995);
Stewart N., Hicks G. G., Paraskeva F., Mowat M., Oncogene 10, 109 (1995).
Li Y., Jenkins C. W., Nichols M. A., Xiong Y., Oncogene 9, 2261 (1994).
Niculescu A. B., et al., Mol. Cell. Biol. 18, 629 (1998). · DOI
El-Deiry W. S., et al., Cancer Res. 55, 2910 (1995);
Kaufmann K., et al., Cell Growth. Diff. 8, 1105 (1997);

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APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis.
Robles, A. I., Bemmels, N. A., Foraker, A. B., & Harris, C. C. (2001) · PubMed · Cited by 190
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Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells
Serebriiskii, I. G., Castelló-Cros, R., Lamb, A., Golemis, E. A., & Cukierman, E. (2008) · Matrix Biology · doi:10.1016/j.matbio.2008.02.008 · Cited by 174
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Gottifredi, V., Karni-Schmidt, O., Shieh, S.-Y., & Prives, C. L. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1066-1076.2001 · Cited by 174
Activation of the p53 DNA Damage Response Pathway after Inhibition of DNA Methyltransferase by 5-Aza-2′-deoxycytidine
Karpf, A. R., Moore, B. C., Ririe, T. O., & Jones, D. A. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.4.751 · Cited by 174
POLYPLOID GIANT CELLS PROVIDE A SURVIVAL MECHANISM FOR p53 MUTANT CELLS AFTER DNA DAMAGE
Illidge, T., Cragg, M. S., Fringes, B., Olive, P. L., & Erenpreisa, J. A. (2000) · Cell Biology International · doi:10.1006/cbir.2000.0557 · Cited by 175
p53 Activation by Small Molecules: Application in Oncology
Vassilev, L. T. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm058174k · Cited by 174
Ribosomal Proteins RPL37, RPS15 and RPS20 Regulate the Mdm2-p53-MdmX Network
Daftuar, L., Zhu, Y. Y., Jacq, X., & Prives, C. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068667 · Cited by 179
MDM2-Regulated Degradation of HIPK2 Prevents p53Ser46 Phosphorylation and DNA Damage-Induced Apoptosis
Rinaldo, C., Prodosmo, A., Mancini, F., Iacovelli, S., Sacchi, A., Moretti, F., & Soddu, S. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.02.008 · Cited by 175
Prognostic Values of microRNAs in Colorectal Cancer
Xi, Y., Formentini, A., Chien, M., Weir, D. B., Russo, J. J., Ju, J., Kornmann, M., & Ju, J. (2006) · Biomarker Insights · doi:10.1177/117727190600100009 · Cited by 172
General aspects of the cellular response to low- and high-LET radiation
Pouget, J., & Mather, S. J. (2001) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s002590100484 · Cited by 183
Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities
Porter, D. C., Farmaki, E., Altilia, S., Schools, G. P., West, D. K., Chen, M., Chang, B.-D., Puzyrev, A. T., Lim, C., Rokow-Kittell, R., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206906109 · Cited by 177
Human papillomaviruses and associated malignancies.
Alani, R. M., & Münger, K. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.1.330 · Cited by 171
H2AX Is Required for Cell Cycle Arrest via the p53/p21 Pathway
Fragkos, M., Jurvansuu, J., & Beard, P. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01830-08 · Cited by 176
p53 from complexity to simplicity: mutant p53 stabilization, gain‐of‐function, and dominant‐negative effect
Blagosklonny, M. V. (2000) · The FASEB Journal · doi:10.1096/fj.99-1078rev · Cited by 170
MDM2-Dependent Downregulation of p21 and hnRNP K Provides a Switch between Apoptosis and Growth Arrest Induced by Pharmacologically Activated p53
Enge, M., Bao, W., Hedström, E., Jackson, S. P., Moumen, A., & Selivanova, G. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.019 · Cited by 172
The tumour suppressor protein p53 can repress transcription of cyclin B
Krause, K. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.22.4410 · Cited by 169
NF-Y Mediates the Transcriptional Inhibition of thecyclin B1, cyclin B2, and cdc25CPromoters upon Induced G2 Arrest
Manni, I., Mazzaro, G., Gurtner, A., Mantovani, R., Haugwitz, U., Krause, K., Engeland, K., Sacchi, A., Soddu, S., & Piaggio, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006052200 · Cited by 168
Human mdm2 Mediates Multiple Mono-ubiquitination of p53 by a Mechanism Requiring Enzyme Isomerization
Lai, Z., Ferry, K. V., Diamond, M. A., Wee, K. E., Kim, Y. B., Ma, J., Yang, T., Benfield, P. A., Copeland, R. A., & Auger, K. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011517200 · Cited by 170
Orchestration of DNA Damage Checkpoint Dynamics across the Human Cell Cycle
Chao, H. X., Poovey, C. E., Privette, A. A., Grant, G. D., Chao, H. Y., Cook, J. G., & Purvis, J. E. (2017) · Cell Systems · doi:10.1016/j.cels.2017.09.015 · Cited by 167
Potent inhibition of tumor survival in vivo by β-lapachone plus taxol: Combining drugs imposes different artificial checkpoints
Li, C. J., Li, Y.-Z., Pinto, A. V., & Pardee, A. B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13369 · Cited by 167
Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy
Vogel, C., Kienitz, A., Hofmann, I., Müller, R., & Bastians, H. (2004) · Oncogene · doi:10.1038/sj.onc.1207860 · Cited by 171
p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells
Chang, B.-D., Broude, E. V., Fang, J., Kalinichenko, T. V., Abdryashitov, R. I., Poole, J. C., & Roninson, I. B. (2000) · Oncogene · doi:10.1038/sj.onc.1203573 · Cited by 168
BAF180 Is a Critical Regulator of p21 Induction and a Tumor Suppressor Mutated in Breast Cancer
Xia, W., Nagase, S., Montia, A. G., Kalachikov, S. M., Keniry, M. E., Su, T., Memeo, L., Hibshoosh, H. H., & Parsons, R. E. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5276 · Cited by 166
Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction
Rew, Y., Sun, D., de Turiso, F. G.-L., Bartberger, M. D., Beck, H. P., Canon, J. R., Chen, A., Chow, D. T., Deignan, J., Fox, B. M., et al. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300354j · Cited by 170
Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents
Nitta, M., Kobayashi, O., Honda, S., Hirota, T., Kuninaka, S., Marumoto, T., Ushio, Y., & Saya, H. (2004) · Oncogene · doi:10.1038/sj.onc.1207873 · Cited by 166

Authors: Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., & Vogelstein, B.
Affiliations: Howard Hughes Medical Institute (US)
F. Bunz, S. Zhou, B. Vogelstein, The Howard Hughes Medical Institute and The Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA. C. Lengauer and K. W. Kinzler, The Johns Hopkins Oncology Center, Baltimore, MD 21231, USA. A. Dutriaux, J. P. Brown, J. Sedivy, Department of Molecular Biology, Cell Biology, and Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA. T. Waldman, Program in Human Genetics and the Johns Hopkins Oncology...
Corresponding author: Vogelstein, B.
ORCID: Bunz, F.
Dutriaux, A.
Waldman, T.
Zhou, S.
Brown, J. P.
Sedivy, J. M.
Kinzler, K. W.
Vogelstein, B.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-11-20
Volume: 282
Issue: 5393
Pages: 1497-1501
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.282.5393.1497
OpenAlex: W2080125477
Cited by: 2,803
References: 50
Citations by year: 2026: 28 · 2025: 39 · 2024: 42 · 2023: 60 · 2022: 69 · 2021: 86 · 2020: 77 · 2019: 76 · 2018: 98 · 2017: 101 · 2016: 103 · 2015: 97 · 2014: 113 · 2013: 155 · 2012: 120
FWCI: 41.60
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA 57345, CA43460, P50CA062924, CA 62924)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords: p53, p21, G2 checkpoint, DNA damage, cell cycle arrest, cyclin-dependent kinase inhibitors, transcriptional activation, gamma radiation, cytokinesis, mitosis, gene disruption
MeSH terms: Cell Line, DNA, DNA Damage, Gamma Rays, Gene Expression Regulation, Humans, Mitosis, Mutation, Tumor Cells, Cultured, Nocodazole, Genes, p53, Tumor Suppressor Protein p53, G2 Phase, CDC2 Protein Kinase, Cyclins, Apoptosis, Cyclin B, Cyclin-Dependent Kinase Inhibitor p21, Cyclin B1

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Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage

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