Cited by 2,803Cancer-related Molecular PathwaysDNA Repair MechanismsMicrotubule and mitosis dynamics

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Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage

Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., Vogelstein, B.·1998·Science

DOI 10.1126/science.282.5393.1497

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Abstract

After DNA damage, many cells appear to enter a sustained arrest in the G 2 phase of the cell cycle. It is shown here that this arrest could be sustained only when p53 was present in the cell and capable of transcriptionally activating the cyclin-dependent kinase inhibitor p21. After disruption of either the p53 or the p21 gene, γ radiated cells progressed into mitosis and exhibited a G 2 DNA content only because of a failure of cytokinesis. Thus, p53 and p21 appear to be essential for maintaining the G 2 checkpoint in human cells.

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Authors: Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., & Vogelstein, B.
Affiliations: Howard Hughes Medical Institute (US)
F. Bunz, S. Zhou, B. Vogelstein, The Howard Hughes Medical Institute and The Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA. C. Lengauer and K. W. Kinzler, The Johns Hopkins Oncology Center, Baltimore, MD 21231, USA. A. Dutriaux, J. P. Brown, J. Sedivy, Department of Molecular Biology, Cell Biology, and Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA. T. Waldman, Program in Human Genetics and the Johns Hopkins Oncology...
Corresponding author: Vogelstein, B.
ORCID: Bunz, F.
Dutriaux, A.
Waldman, T.
Zhou, S.
Brown, J. P.
Sedivy, J. M.
Kinzler, K. W.
Vogelstein, B.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-11-20
Volume: 282
Issue: 5393
Pages: 1497-1501
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.282.5393.1497
OpenAlex: W2080125477
Cited by: 2,803
References: 50
Citations by year: 2026: 28 · 2025: 39 · 2024: 42 · 2023: 60 · 2022: 69 · 2021: 86 · 2020: 77 · 2019: 76 · 2018: 98 · 2017: 101 · 2016: 103 · 2015: 97 · 2014: 113 · 2013: 155 · 2012: 120
FWCI: 41.60
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA 57345, CA43460, P50CA062924, CA 62924)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords: p53, p21, G2 checkpoint, DNA damage, cell cycle arrest, cyclin-dependent kinase inhibitors, transcriptional activation, gamma radiation, cytokinesis, mitosis, gene disruption
MeSH terms: Cell Line, DNA, DNA Damage, Gamma Rays, Gene Expression Regulation, Humans, Mitosis, Mutation, Tumor Cells, Cultured, Nocodazole, Genes, p53, Tumor Suppressor Protein p53, G2 Phase, CDC2 Protein Kinase, Cyclins, Apoptosis, Cyclin B, Cyclin-Dependent Kinase Inhibitor p21, Cyclin B1

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Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage

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