Cited by 2,803Cancer-related Molecular PathwaysDNA Repair MechanismsMicrotubule and mitosis dynamics

The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.

Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage

Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., Vogelstein, B.·1998·Science

DOI 10.1126/science.282.5393.1497

Open this paper in CoChat — free account

Abstract

After DNA damage, many cells appear to enter a sustained arrest in the G 2 phase of the cell cycle. It is shown here that this arrest could be sustained only when p53 was present in the cell and capable of transcriptionally activating the cyclin-dependent kinase inhibitor p21. After disruption of either the p53 or the p21 gene, γ radiated cells progressed into mitosis and exhibited a G 2 DNA content only because of a failure of cytokinesis. Thus, p53 and p21 appear to be essential for maintaining the G 2 checkpoint in human cells.

Integrity signals

Registry

Crossref · 10.1126/science.282.5393.1497

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693
Participation of p53 protein in the cellular response to DNA damage.
Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761
Self-citation
p21 is a universal inhibitor of cyclin kinases
Xiong, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R., & Beach, D. (1993) · Nature · doi:10.1038/366701a0 · Cited by 3,691
Universal control mechanism regulating onset of M-phase
Nurse, P. (1990) · Nature · doi:10.1038/344503a0 · Cited by 2,798
Cell Cycle Control and Cancer
Hartwell, L. H., & Kastan, M. B. (1994) · Science · doi:10.1126/science.7997877 · Cited by 2,539
p53: puzzle and paradigm.Preprint
Ko, L. J., & Prives, C. L. (1996) · Genes & Development · doi:10.1101/gad.10.9.1054 · Cited by 2,346
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P. (1995) · Cell · doi:10.1016/0092-8674(95)90039-x · Cited by 2,113
Mutations of mitotic checkpoint genes in human cancers
Cahill, D. P., Lengauer, C., Yu, J., Riggins, G. J., Willson, J. K. V., Markowitz, S. D., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/32688 · Cited by 1,490
Self-citation
Mitotic and G 2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216
Peng, C.-Y., Graves, P. R., Thoma, R. S., Wu, Z., Shaw, A. S., & Piwnica-Worms, H. (1997) · Science · doi:10.1126/science.277.5331.1501 · Cited by 1,341
Is a p53-Regulated Inhibitor of G2/M Progression
Hermeking, H., Lengauer, C., Polyak, K., He, T.-C., Zhang, L., Thiagalingam, S., Kinzler, K. W., & Vogelstein, B. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80002-7 · Cited by 1,251
Self-citation

Show all 50 references

Research works printed but not linked: 13

Kastan M. B., Onyekwere O., Sidransky D., Vogelstein B., Craig R. W., Cancer Res. 51, 6304 (1991);
Waldman T., Kinzler K. W., Vogelstein B., Cancer Res. 55, 5187 (1995).
Powell S. N., et al., Cancer Res. 55, 1643 (1995);
Fan S., et al., Cancer Res. 55, 1649 (1995);
Russell K. J., et al., ibid. 55, 1639 (1995).
Khan S. H., Wahl G. M., Cancer Res. 58, 396 (1998);
Michieli P., et al., Cancer Res. 54, 3391 (1994);
Paules R. S., et al., Cancer Res 55, 1763 (1995);
Stewart N., Hicks G. G., Paraskeva F., Mowat M., Oncogene 10, 109 (1995).
Li Y., Jenkins C. W., Nichols M. A., Xiong Y., Oncogene 9, 2261 (1994).
Niculescu A. B., et al., Mol. Cell. Biol. 18, 629 (1998). · DOI
El-Deiry W. S., et al., Cancer Res. 55, 2910 (1995);
Kaufmann K., et al., Cell Growth. Diff. 8, 1105 (1997);

Sorted by citations

Items 801–900 of 1,018

Immune recognition of cyclin B1 as a tumor antigen is a result of its overexpression in human tumors that is caused by non-functional p53
Yu, M., Zhan, Q., & Finn, O. J. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(02)00026-3 · Cited by 74
Molecular aspects of esophageal squamous cell carcinoma carcinogenesis
Lehrbach, D. M., Nita, M. E., & Cecconello, I. (2003) · Arquivos de Gastroenterologia · doi:10.1590/s0004-28032003000400011 · Cited by 73
Sanguinarine causes DNA damage and p53-independent cell death in human colon cancer cell lines
Matkar, S. S., Wrischnik, L. A., & Hellmann‐Blumberg, U. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2007.12.006 · Cited by 73
iASPP and Chemoresistance in Ovarian Cancers: Effects on Paclitaxel-Mediated Mitotic Catastrophe
Jiang, L., Siu, M. K. Y., Wong, O. G., Tam, K.-F., Lü, X., Lam, E. W. ‐., Ngan, H., Le, X., Wong, E. S. Y., Monteiro, L. J., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0588 · Cited by 75
Non-Coding RNAs and Resistance to Anticancer Drugs in Gastrointestinal Tumors
Hahne, J. C., & Valeri, N. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00226 · Cited by 74
Transcription Factor Yin Yang 1 Stimulates Poly(ADP-Ribosyl)ation and DNA Repair
Oei, S. L., & Shi, Y. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4985 · Cited by 73
Gene Targeting in Human Cells Without Isogenic DNA
Sedivy, J. M., Vogelstein, B., Liber, H. L., Hendrickson, E. A., & Rosmarin, A. G. (1999) · Science · doi:10.1126/science.283.5398.9a · Cited by 73
Self-citation
Progress in cancer genetics: Lessons from pancreatic cancer
Goggins, M., Kern, S. E., Offerhaus, J. G. A., & Hruban, R. H. (1999) · Annals of Oncology · doi:10.1093/annonc/10.suppl_4.s4 · Cited by 75
Cell Cycle Checkpoint Function in Bladder Cancer
Doherty, S. C., McKEOWN, S. R., McKelvey‐Martin, V. J., Downes, C. S., Atala, A., Yoo, J. J., Simpson, D. A., & Kaufmann, W. K. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg120 · Cited by 73
Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive.
Guo, N., Faller, D. V., & Vaziri, C. (2002) · PubMed · Cited by 73
The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation
Tabach, Y., Milyavsky, M., Shats, I., Brosh, R., Zuk, O., Yitzhaky, A., Mantovani, R., Domany, E., Rotter, V., & Pilpel, Y. (2005) · Molecular Systems Biology · doi:10.1038/msb4100030 · Cited by 72
Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2
Xu, R., Garcı́a-Barros, M., Wen, S., Li, F., Lin, C., Hannun, Y. A., Obeid, L. M., & Mao, C. (2017) · Cell Death and Differentiation · doi:10.1038/s41418-017-0018-y · Cited by 73
p53: From Fundamental Biology to Clinical Applications in Cancer
Capuozzo, M., Santorsola, M., Bocchetti, M., Perri, F., Cascella, M., Granata, V., Celotto, V., Gualillo, O., Cossu, A. M., Nasti, G., et al. (2022) · Biology · doi:10.3390/biology11091325 · Cited by 74
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis.
Lee, C., Blum, J. M., & Kirsch, D. G. (2013) · PubMed · Cited by 72
Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control
Klein, D. K., Hoffmann, S., Ahlskog, J. K., O’Hanlon, K. A., Quaas, M., Larsen, B. D., Rolland, B., Rösner, H. I., Walter, D., Kousholt, A. N., et al. (2015) · Nature Communications · doi:10.1038/ncomms6800 · Cited by 72
Chromosomal breaks during mitotic catastrophe trigger γH2AX–ATM–p53-mediated apoptosis
Imreh, G., Norberg, H. V., Imreh, S., & Zhivotovsky, B. (2011) · Journal of Cell Science · doi:10.1242/jcs.081612 · Cited by 72
Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells
Tao, Y., Zhang, P., Frascogna, V., Lécluse, Y., Auperin, A., Bourhis, J., & Deutsch, É. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6604083 · Cited by 72
Wild-type p53 and p73 negatively regulate expression of proliferation related genes
Scian, M. J., Carchman, E. H., Mohanraj, L., Stagliano, K. E., Anderson, M. A. E., Deb, D., Crane, B., Kiyono, T., Windle, B. E., Deb, S., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210898 · Cited by 73
Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells
Campregher, C., Luciani, M. G., & Gasché, C. (2008) · Gut · doi:10.1136/gut.2007.141556 · Cited by 75
Pharmacologic p53 Activation Blocks Cell Cycle Progression but Fails to Induce Senescence in Epithelial Cancer Cells
Huang, B., Deo, D. D., Xia, M., & Vassilev, L. T. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0144 · Cited by 73
α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere
Sathyan, K. M., Fachinetti, D., & Foltz, D. R. (2017) · Nature Communications · doi:10.1038/ncomms14678 · Cited by 72
Lanthanide-doped nanoparticles conjugated with an anti-CD33 antibody and a p53-activating peptide for acute myeloid leukemia therapy
Niu, F., Yan, J., Ma, B., Li, S., Shao, Y., He, P., Zhang, W., He, W., Ma, P. X., & Lu, W. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.03.025 · Cited by 72
WT1-p53 Interactions in Insulin-like Growth Factor-I Receptor Gene Regulation
Idelman, G., Glaser, T., Roberts, C. T., & Werner, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211606200 · Cited by 72
Disruption of the Rad9/Rad1/Hus1 (9–1–1) complex leads to checkpoint signaling and replication defects
Bao, S., Lu, T., Wang, X. A., Zheng, H., Wang, L., Wei, Q., Hittelman, W. N., & Li, L. (2004) · Oncogene · doi:10.1038/sj.onc.1207753 · Cited by 72
The molecular control of DNA damage-induced cell death
Coultas, L., & Strasser, A. (2000) · APOPTOSIS · doi:10.1023/a:1009617727938 · Cited by 72
Distinct Roles of Ape1 Protein in the Repair of DNA Damage Induced by Ionizing Radiation or Bleomycin
Fung, H., & Demple, B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.146498 · Cited by 71
Goniothalamin induces cell cycle-specific apoptosis by modulating the redox status in MDA-MB-231 cells
Chen, W.-Y., Wu, C., Lan, Y., Chang, F., Teng, C., & Wu, Y. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.08.047 · Cited by 71
Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells
Wendt, J., Radetzki, S., von Haefen, C., Hemmati, P., Güner, D., Schulze‐Osthoff, K., Dörken, B., & Daniel, P. T. (2005) · Oncogene · doi:10.1038/sj.onc.1209031 · Cited by 71
Negative regulation of p21 by β-catenin/TCF signaling: a novel mechanism by which cell adhesion molecules regulate cell proliferation
Kamei, J., Toyofuku, T., & Hori, M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.10.129 · Cited by 71
A Mortalin/HSPA9-Mediated Switch in Tumor-Suppressive Signaling of Raf/MEK/Extracellular Signal-Regulated Kinase
Wu, P., Hong, S., Veeranki, S., Karkhanis, M. S., Starenki, D., Plaza, J. A., & Park, J. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00021-13 · Cited by 71
Checkpoint adaptation in human cells
Syljuåsen, R. G. (2007) · Oncogene · doi:10.1038/sj.onc.1210402 · Cited by 78
Disruption of Cell Cycle Kinetics by Benzo[a]pyrene: Inverse Expression Patterns of BRCA-1 and p53 in MCF-7 Cells Arrested in S and G2
Jeffy, B. D., Chen, E. J., Gudas, J. M., & Romagnolo, D. F. (2000) · Neoplasia · doi:10.1038/sj.neo.7900104 · Cited by 71
The p53-regulated Cyclin-dependent Kinase Inhibitor, p21 (cip1, waf1, sdi1), Is Not Required for Global Genomic and Transcription-coupled Nucleotide Excision Repair of UV-induced DNA Photoproducts
Adimoolam, S., Lin, C., & Ford, J. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102240200 · Cited by 71
Models of reactive oxygen species in cancer
Lu, W., Ogasawara, M. A., & Huang, P. (2007) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2007.10.005 · Cited by 72
Synthesis of cytochrome c oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death
Wanka, C., Brucker, D. P., Bähr, O., Ronellenfitsch, M. W., Weller, M., Steinbach, J. P., & Rieger, J. (2011) · Oncogene · doi:10.1038/onc.2011.530 · Cited by 73
p53- and p21-dependent premature APC/C–Cdh1 activation in G2 is part of the long-term response to genotoxic stress
Wiebusch, L., & Hagemeier, C. (2010) · Oncogene · doi:10.1038/onc.2010.99 · Cited by 72
Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells
Taylor, W. R., Fedorka, S. R., Gad, I., Shah, R. V., Alqahtani, H. D., Koranne, R., Kuganesan, N., Dlamini, S., Rogers, T., Al-Hamashi, A. A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-42251-5 · Cited by 71
p53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1
Asher, G., Lotem, J., Tsvetkov, P., Reiss, V., Sachs, L., & Shaul, Y. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436329100 · Cited by 70
E2F Mediates Sustained G2 Arrest and Down-regulation of Stathmin and AIM-1 Expression in Response to Genotoxic Stress
Polager, S., & Ginsberg, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210327200 · Cited by 70
Regulation of p53 by TopBP1: a Potential Mechanism for p53 Inactivation in Cancer
Liu, K., Bellam, N., Lin, H., Wang, B., Stockard, C. R., Grizzle, W. E., & Lin, W.-C. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01140-08 · Cited by 70
Critical Role for Mouse Hus1 in an S-Phase DNA Damage Cell Cycle Checkpoint
Weiss, R. S., Leder, P., & Vaziri, C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.791-803.2003 · Cited by 71
Up-regulation, Modification, and Translocation of S100A6 Induced by Exposure to Ionizing Radiation Revealed by Proteomics Profiling
Orre, L. M., Pernemalm, M., Lengqvist, J., Lewensohn, R., & Lehtiö, J. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700202-mcp200 · Cited by 70
Human T-cell leukemia virus type 1 Tax interacts with Chk1 and attenuates DNA-damage induced G2 arrest mediated by Chk1
Park, H. U., Jeong, J., Chung, J. H., & Brady, J. N. (2004) · Oncogene · doi:10.1038/sj.onc.1207644 · Cited by 74
DNA damage induces the IL-6/STAT3 signaling pathway, which has anti-senescence and growth-promoting functions in human tumors
Yun, U. J., Park, S. E., Jo, Y. S., Kim, J., & Shin, D. Y. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.04.003 · Cited by 69
The Structure of the Human Cell Cycle
Stallaert, W., Kedziora, K. M., Taylor, C. D., Zikry, T. M., Ranek, J. S., Sobon, H. K., Taylor, S. R., Young, C. L., Cook, J. G., & Purvis, J. E. (2021) · Cell Systems · doi:10.1016/j.cels.2021.10.007 · Cited by 80
Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium
Moding, E. J., Lee, C., Castle, K. D., Oh, P., Mao, L., Zha, S., Min, H. D., Ma, Y., Das, S. K., & Kirsch, D. G. (2014) · Journal of Clinical Investigation · doi:10.1172/jci73932 · Cited by 73
A critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation
Jiang, P., Du, W., & Yang, X. (2013) · Cell Cycle · doi:10.4161/cc.27267 · Cited by 71
Dietary Isothiocyanates Inhibit Caco-2 Cell Proliferation and Induce G2/M Phase Cell Cycle Arrest, DNA Damage, and G2/M Checkpoint Activation
Visanji, J. M., Thompson, D. G., Padfield, P. J., Duthie, S. J., & Pirie, L. P. (2004) · Journal of Nutrition · doi:10.1093/jn/134.11.3121 · Cited by 69
Roles of p53 and Caspases in the Induction of Cell Cycle Arrest and Apoptosis by HIV-1 vpr
Shostak, L. D., Ludlow, J. W., Fisk, J., Pursell, S., Rimel, B. J., Nguyen, D. X., Rosenblatt, J. D., & Planelles, V. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4568 · Cited by 69
DNA Damage Triggers p21WAF1-dependent Emi1 Down-Regulation That Maintains G2 Arrest
Lee, J., Kim, J. A., Barbier, V., Fotedar, A., & Fotedar, R. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-08-0818 · Cited by 68
Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other Gq-coupled receptors
Becker, J. A. J., Mirjolet, J.-F., Bernard, J., Burgeon, E., Simons, M.-J., Vassart, G., Parmentier, M., & Libert, F. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.094 · Cited by 69
Inhibition of matrix metalloproteinase‐2 enhances radiosensitivity by abrogating radiation‐induced FoxM1‐mediated G2/M arrest in A549 lung cancer cells
Chetty, C., Bhoopathi, P., Rao, J. S., & Lakka, S. S. (2008) · International Journal of Cancer · doi:10.1002/ijc.24209 · Cited by 68
Eukaryotic Translation Elongation Factor 1-Alpha 1 Inhibits p53 and p73 Dependent Apoptosis and Chemotherapy Sensitivity
Blanch, A., Robinson, F., Watson, I. R., Cheng, L. S., & Irwin, M. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066436 · Cited by 68
Loss of G 1 /S Checkpoint in Human Immunodeficiency Virus Type 1-Infected Cells Is Associated with a Lack of Cyclin-Dependent Kinase Inhibitor p21/Waf1
Clark, E., Santiago, F., Deng, L., Chong, S. Y., de la Fuente, C., Wang, L., Fu, P., Stein, D., Denny, T. N., Lanka, V. K., et al. (2000) · Journal of Virology · doi:10.1128/jvi.74.11.5040-5052.2000 · Cited by 68
Targeting Colorectal Cancer Proliferation, Stemness and Metastatic Potential Using Brassicaceae Extracts Enriched in Isothiocyanates: A 3D Cell Model-Based Study
Pereira, L. P., Silva, P., Duarte, M., Rodrigues, L. A., Duarte, C. M. M., Albuquerque, C. M., & Serra, T. (2017) · Nutrients · doi:10.3390/nu9040368 · Cited by 70
Combined modality radioimmunotherapy for human prostate cancer xenografts with taxanes and 90yttrium‐DOTA‐peptide‐ChL6
OʼDonnell, R. T., DeNardo, S. J., Miers, L. A., Lamborn, K. R., Kukis, D. L., DeNardo, G. L., & Meyers, F. J. (2001) · The Prostate · doi:10.1002/pros.10029 · Cited by 68
Abolition of Cyclin-Dependent Kinase Inhibitor p16 Ink4a and p21 Cip1/Waf1 Functions Permits Ras-Induced Anchorage-Independent Growth in Telomerase-Immortalized Human Fibroblasts
Wei, W., Jobling, W. A., Chen, W., Hahn, W. C., & Sedivy, J. M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.8.2859-2870.2003 · Cited by 68
Self-citation
p53 controls low DNA damage-dependent premeiotic checkpoint and facilitates DNA repair during spermatogenesis.
Schwartz, D., Goldfinger, N., Kam, Z., & Rotter, V. (1999) · PubMed · Cited by 68
Protein Kinase D as a Potential Chemotherapeutic Target for Colorectal Cancer
Wei, N., Chu, E., Wipf, P., & Schmitz, J. C. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0880 · Cited by 67
Cyclin B1/Cdk1 Phosphorylation of Mitochondrial p53 Induces Anti-Apoptotic Response
Nantajit, D., Fan, M., Duru, N., Wen, Y., Reed, J. C., & Li, J. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012341 · Cited by 68
Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement
af Hällström, T., Jäämaa, S., Mönkkönen, M., Peltonen, K., Andersson, L. C., Medema, R. H., Peehl, D. M., & Laiho, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609299104 · Cited by 68
Human tumor suppressor p53 and DNA viruses
Collot-Teixeira, S., Bass, J., Denis, F., & Ranger‐Rogez, S. (2004) · Reviews in Medical Virology · doi:10.1002/rmv.431 · Cited by 69
Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents
Ribeiro, C. J. A., Amaral, J. D., Rodrigues, C. M. P., Moreira, R., & Santos, M. M. M. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.10.048 · Cited by 67
Gadd45-α and Gadd45-γ utilize p38 and JNK signaling pathways to induce cell cycle G2/M arrest in Hep-G2 hepatoma cells
Zhu, N., Shao, Y., Xu, L., Yu, L., & Sun, L. (2008) · Molecular Biology Reports · doi:10.1007/s11033-008-9419-9 · Cited by 67
Cdk2-dependent phosphorylation of the NF-Y transcription factor is essential for the expression of the cell cycle-regulatory genes and cell cycle G1/S and G2/M transitions
Chae, H.-D., Yun, J., Bang, Y., & Shin, D. Y. (2004) · Oncogene · doi:10.1038/sj.onc.1207482 · Cited by 67
Antisense Bcl-xl down-regulation switches the response to topoisomerase I inhibition from senescence to apoptosis in colorectal cancer cells, enhancing global cytotoxicity.
Hayward, R. L., Macpherson, J. S., Cummings, J., Monia, B. P., Smyth, J. F., & Jodrell, D. I. (2003) · PubMed · Cited by 67
Computerized Video Time-Lapse Microscopy Studies of Ionizing Radiation-Induced Rapid-Interphase and Mitosis-Related Apoptosis in Lymphoid Cells
Endlich, B., Radford, I. R., Forrester, H. B., & Dewey, W. C. (2000) · Radiation Research · doi:10.1667/0033-7587(2000)153[0036:cvtlms]2.0.co;2 · Cited by 66
F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress
Malonia, S. K., Dutta, P., Santra, M. K., & Green, M. R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510929112 · Cited by 66
Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F₁F₀-ATP synthase
Bergeaud, M., Mathieu, L., Guillaume, A., Moll, U. M., Mignotte, B., Floch, N. L., Vayssière, J., & Rincheval, V. (2013) · Cell Cycle · doi:10.4161/cc.25870 · Cited by 74
p53-Based cyclotherapy: exploiting the ‘guardian of the genome’ to protect normal cells from cytotoxic therapy
Rao, B., Laı́n, S., & Thompson, A. M. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.702 · Cited by 66
A Genetic Screen Identifies TCF3/E2A and TRIAP1 as Pathway-Specific Regulators of the Cellular Response to p53 Activation
Andrysík, Z., Kim, J., Tan, A. C., & Espinosa, J. M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.014 · Cited by 68
Clastogenicity of the fungicide afugan in cultured human lymphocytes
Yüzbaşıoğlu, D., Çelık, M., Yılmaz, S., Ünal, F. Ş., & Aksoy, H. (2006) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2006.01.001 · Cited by 66
Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage
Logan, I. R., McNeill, H. V., Cook, S., Lü, X., Meek, D. W., Fuller-Pace, F. V., Lunec, J., & Robson, C. N. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp180 · Cited by 68
Cooperative actions of p21WAF1 and p53 induce Slug protein degradation and suppress cell invasion
Kim, J., Bae, S., An, S., Park, J. K., Kim, E. M., Hwang, S., Kim, W., & Um, H. (2014) · EMBO Reports · doi:10.15252/embr.201438587 · Cited by 66
hSSB1 regulates both the stability and the transcriptional activity of p53
Xu, S., Wu, Y., Chen, Q., Cao, J., Hu, K., Tang, J., Sang, Y., Lai, F., Wang, L., Zhang, R., et al. (2012) · Cell Research · doi:10.1038/cr.2012.162 · Cited by 68
Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target
da Costa, D. C. F., Fialho, E., & Silva, J. L. (2017) · Molecules · doi:10.3390/molecules22061014 · Cited by 68
EphA2 Up-regulation induced by deoxycholic acid in human colon carcinoma cells, an involvement of extracellular signal-regulated kinase and p53-independence
Li, Z., Tanaka, M., Kataoka, H., Nakamura, R., Sanjar, R., Shinmura, K., & Sugimura, H. (2003) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-003-0493-z · Cited by 66
p53-Independent Expression of p21CIP1/WAF1in Plasmacytic Cells during G2Cell Cycle Arrest Induced byActinobacillus actinomycetemcomitansCytolethal Distending Toxin
Sato, T., Koseki, T., Yamato, K., Saiki, K., Konishi, K., Yoshikawa, M., Ishikawa, I., & Nishihara, T. (2002) · Infection and Immunity · doi:10.1128/iai.70.2.528-534.2002 · Cited by 66
Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53
Calvisi, D. F., Simile, M. M., Ladu, S., Frau, M., Evert, M., Tomasi, M. L., Demartis, M. I., Daino, L., Seddaiu, M. A., Brozzetti, S., et al. (2011) · Hepatology · doi:10.1002/hep.24174 · Cited by 65
The p53/microRNA Network in Cancer: Experimental and Bioinformatics Approaches
Hünten, S., Siemens, H., Kaller, M., & Hermeking, H. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-5590-1_5 · Cited by 66
Design and advanced characterization of quercetin-loaded nano-liposomes prepared by high-pressure homogenization
Melchior, S., Codrich, M., Gorassini, A., Méhn, D., Ponti, J., Verardo, G., Tell, G., Calzolai, L., & Calligaris, S. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.136680 · Cited by 65
ATR mediates cisplatin resistance in a p53 genotype-specific manner
Sangster‐Guity, N., Conrad, B., Papadopoulos, N., & Bunz, F. (2011) · Oncogene · doi:10.1038/onc.2010.624 · Cited by 65
Self-citation
Gambogic acid triggers DNA damage signaling that induces p53/p21Waf1/CIP1 activation through the ATR-Chk1 pathway
Rong, J., Hu, R., Song, X., Ha, J., Lu, N., Qi, Q., Tao, L., You, Q., & Guo, Q. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.03.016 · Cited by 65
Roles of p53 in Herpes Simplex Virus 1 Replication
Maruzuru, Y., Fujii, H., Oyama, M., Kozuka‐Hata, H., Kato, A., & Kawaguchi, Y. (2013) · Journal of Virology · doi:10.1128/jvi.01581-13 · Cited by 66
Rbm24, an RNA-binding Protein and a Target of p53, Regulates p21 Expression via mRNA Stability
Jiang, Y., Zhang, M., Qian, Y., Xu, E., Zhang, J., & Chen, X. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.524413 · Cited by 65
The molecular mechanism of G2/M cell cycle arrest induced by AFB1 in the jejunum
Yin, H., Jiang, M., Peng, X., Cui, H., Zhou, Y., He, M., Zuo, Z., Ouyang, P., Fan, J., & Fang, J. S. (2016) · Oncotarget · doi:10.18632/oncotarget.9594 · Cited by 65
Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes
Tran, T. Q., Gabra, M. B. I., Lowman, X. H., Yang, Y., Reid, M. A., Pan, M., O'Connor, T. R., & Kong, M. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2002810 · Cited by 65
Yin Yang 1 promotes the Warburg effect and tumorigenesis via glucose transporter GLUT3
Wang, Y., Wu, S., Huang, C., Li, Y., Zhao, H., & Kasim, V. (2018) · Cancer Science · doi:10.1111/cas.13662 · Cited by 65
Role of reactive oxygen species in cells overexpressing manganese superoxide dismutase: mechanism for induction of radioresistance.
Takada, Y., Hachiya, M., Park, S., Osawa, Y., Ozawa, T., & Akashi, M. (2002) · PubMed · Cited by 65
Defects in transforming growth factor-β signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes
Glick, A. B., Popescu, N. C., Alexander, V., Ueno, H., Böttinger, E. P., & Yuspa, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14949 · Cited by 65
Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs
Iwasa, T., Okamoto, I., Takezawa, K., Yamanaka, K., Nakahara, T., Kita, A., Koutoku, H., Sasamata, M., Hatashita, E., Yamada, Y., et al. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605713 · Cited by 64
Endonuclease G: A role for the enzyme in recombination and cellular proliferation
Huang, K.-J., Ku, C., & Lehman, I. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603445103 · Cited by 64
HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53
Hällgren, O., Gustafsson, L., Irjala, H., Selivanova, G., Orrenius, S., & Svanborg, C. (2006) · APOPTOSIS · doi:10.1007/s10495-006-3607-7 · Cited by 64
p53 Targets Simian Virus 40 Large T Antigen for Acetylation by CBP
Poulin, D. L., Kung, A. L., & DeCaprio, J. A. (2004) · Journal of Virology · doi:10.1128/jvi.78.15.8245-8253.2004 · Cited by 64
p21B, a variant of p21Waf1/Cip1, is induced by the p53 family
Nozell, S. E., & Chen, X. (2002) · Oncogene · doi:10.1038/sj.onc.1205191 · Cited by 65
Oxidative stress-induced cyclin D1 depletion and its role in cell cycle processing
Pyo, C.-W., Choi, J. H., Oh, S.-M., & Choi, S.-Y. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.07.030 · Cited by 64
Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade
Chang, H.-L., Chen, C., Hsu, Y.-F., Kuo, W.-S., Ou, G., Chiu, P.-T., Huang, Y., & Hsu, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.04.011 · Cited by 68
p53 and Cell Cycle Dependent Transcription of kinesin family member 23 (KIF23) Is Controlled Via a CHR Promoter Element Bound by DREAM and MMB Complexes
Fischer, M., Grundke, I., Sohr, S., Quaas, M., Hoffmann, S., Knörck, A., Gumhold, C., & Rother, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063187 · Cited by 64
Identification of Tcf-4 as a transcriptional target of p53 signalling
Rother, K., Johne, C., Spiesbach, K., Haugwitz, U., Tschöp, K., Wasner, M., Klein‐Hitpaß, L., Möröy, T., Mössner, J., & Engeland, K. (2004) · Oncogene · doi:10.1038/sj.onc.1207464 · Cited by 65
Combining chemotherapeutic agents and netrin‐1 interference potentiates cancer cell death
Paradisi, A., Creveaux, M., Gibert, B., Devailly, G., Redoulez, E., Neves, D., Cleyssac, E., Treilleux, I., Klein, C., Niederfellner, G. J., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201302654 · Cited by 63

Authors: Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., & Vogelstein, B.
Affiliations: Howard Hughes Medical Institute (US)
F. Bunz, S. Zhou, B. Vogelstein, The Howard Hughes Medical Institute and The Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA. C. Lengauer and K. W. Kinzler, The Johns Hopkins Oncology Center, Baltimore, MD 21231, USA. A. Dutriaux, J. P. Brown, J. Sedivy, Department of Molecular Biology, Cell Biology, and Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA. T. Waldman, Program in Human Genetics and the Johns Hopkins Oncology...
Corresponding author: Vogelstein, B.
ORCID: Bunz, F.
Dutriaux, A.
Waldman, T.
Zhou, S.
Brown, J. P.
Sedivy, J. M.
Kinzler, K. W.
Vogelstein, B.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-11-20
Volume: 282
Issue: 5393
Pages: 1497-1501
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.282.5393.1497
OpenAlex: W2080125477
Cited by: 2,803
References: 50
Citations by year: 2026: 28 · 2025: 39 · 2024: 42 · 2023: 60 · 2022: 69 · 2021: 86 · 2020: 77 · 2019: 76 · 2018: 98 · 2017: 101 · 2016: 103 · 2015: 97 · 2014: 113 · 2013: 155 · 2012: 120
FWCI: 41.60
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA 57345, CA43460, P50CA062924, CA 62924)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords: p53, p21, G2 checkpoint, DNA damage, cell cycle arrest, cyclin-dependent kinase inhibitors, transcriptional activation, gamma radiation, cytokinesis, mitosis, gene disruption
MeSH terms: Cell Line, DNA, DNA Damage, Gamma Rays, Gene Expression Regulation, Humans, Mitosis, Mutation, Tumor Cells, Cultured, Nocodazole, Genes, p53, Tumor Suppressor Protein p53, G2 Phase, CDC2 Protein Kinase, Cyclins, Apoptosis, Cyclin B, Cyclin-Dependent Kinase Inhibitor p21, Cyclin B1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks