The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain
Abstract
Programmed cell death (apoptosis) occurs during normal development of the central nervous system. However, the mechanisms that determine which neurons will succumb to apoptosis are poorly understood. Blockade of N -methyl- d -aspartate (NMDA) glutamate receptors for only a few hours during late fetal or early neonatal life triggered widespread apoptotic neurodegeneration in the developing rat brain, suggesting that the excitatory neurotransmitter glutamate, acting at NMDA receptors, controls neuronal survival. These findings may have relevance to human neurodevelopmental disorders involving prenatal (drug-abusing mothers) or postnatal (pediatric anesthesia) exposure to drugs that block NMDA receptors.
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In the citing paper
“For instance, exposure to N-methyl-D-aspartate (NMDA) antagonist, ethanol, or general anesthetics, causes a significant increase in neuronal degeneration at P6–P7456.”
From Transient blockade of ERK phosphorylation in the critical period causes autistic phenotypes as an adult in mice (2015) · cites this paper as [5]
In the citing paper
“Early post-natal, but not adolescent, deletion of Grin1 in mouse forebrain interneurons reduced their expression of parvalbumin and glutamate decarboxylase 1 (GAD1, also known as GAD67), and caused cortical disinhibition and asynchrony 30,31 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [30]
In the citing paper
“The behavioural deficits induced by interneuronal Grin1 deletion are exacerbated by social isolation stress 30 , which models aspects of known environmental risks for schizophrenia, including childhood maltreatment and psychosocial adverse events 1 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [30]
Citations
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Research works printed but not linked: 5
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Cited by
Sorted by citations
Items 1,001–1,002 of 1,002
Sedation in the emergency department: A complex and multifactorial challenge
Kennedy, R. M. (2015) · Pediatric Sedation Outside of the Operating Room · doi:10.1007/978-1-4939-1390-9_19 · Cited by 4
Sedation in the Emergency Department: A Complex and Multifactorial Challenge
Kennedy, R. M. (2021) · Pediatric Sedation Outside of the Operating Room · doi:10.1007/978-3-030-58406-1_22 · Cited by 1
Metadata
- Authors
- Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vöckler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L., & Olney, J. W.
- Affiliations
- Washington University in St. Louis (US)
- C. Ikonomidou, F. Bosch, M. Miksa, P. Bittigau, J. Vöckler, V. Stefovska, Department of Pediatric Neurology, Charité-Virchow Clinics, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany. K. Dikranian, T. I. Tenkova, J. W. Olney, Department of Psychiatry, Washington University School of Medicine, 4940 Children's Place, St. Louis, MO 63110, USA. L. Turski, Eisai London Research Laboratories, Bernard Katz Building, University College London, Gower Street, London WC1E 6BT, UK.
- Corresponding author
- Ikonomidou, Chrysanthy
- Venue
- Science
- Published
- 1999-01
- Volume
- 283
- Issue
- 5398
- Pages
- 70-74
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036650593
- Cited by
- 2,055
- References
- 33
- Citations by year
- 2026: 17 · 2025: 36 · 2024: 41 · 2023: 43 · 2022: 49 · 2021: 73 · 2020: 63 · 2019: 148 · 2018: 85 · 2017: 86 · 2016: 112 · 2015: 98 · 2014: 94 · 2013: 92 · 2012: 92
- FWCI
- 13.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k05mh038894-20)
- National Institute on Aging (AG11355, P01AG011355)
- National Institute of Mental Health (MH-38894)
- National Institute on Drug Abuse (R01DA005072, DA05072)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- NMDA receptor blockade, apoptosis, neuronal survival, glutamate excitotoxicity, brain development, fetal brain development, neonatal brain development, neurodevelopmental disorders, prenatal drug exposure, pediatric anesthesia, excitatory neurotransmitter
- MeSH terms
- Animals, Brain, Calcium Channel Blockers, Dose-Response Relationship, Drug, Fetus, Haloperidol, Immunohistochemistry, Microscopy, Electron, Nerve Degeneration, Neurons, Quinoxalines, Scopolamine, Receptors, N-Methyl-D-Aspartate, Dizocilpine Maleate, Apoptosis, Dopamine Antagonists, Excitatory Amino Acid Antagonists, Muscarinic Antagonists, In Situ Nick-End Labeling, Rats
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