Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444

Cell Death: The Significance of Apoptosis

Wyllie, A. H., Kerr, J. F. R., & Currie, A. R. (1980) · International review of cytology · doi:10.1016/s0074-7696(08)62312-8 · Cited by 7,151

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90210-0 · Cited by 3,535

RECOGNITION OF THE FETAL ALCOHOL SYNDROME IN EARLY INFANCY

Jones, K., & Smith, D. (1973) · The Lancet · doi:10.1016/s0140-6736(73)91092-1 · Cited by 2,780

Comparative aspects of the brain growth spurt

Dobbing, J., & Sands, J. (1979) · Early Human Development · doi:10.1016/0378-3782(79)90022-7 · Cited by 2,506

Ketamine—its pharmacology and therapeutic uses

white, P. F., Way, W. L., & Trevor, A. J. (1982) · Anesthesiology · doi:10.1097/00000542-198202000-00007 · Cited by 1,474

Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons

Lovinger, D. M., White, G., & Weight, F. F. (1989) · Science · doi:10.1126/science.2467382 · Cited by 1,448

In situ detection of fragmented DNA (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note*1

Kraupp, B. G., Ruttkay-Nedecký, B., Koudelka, H., Bukowska, K., Bursch, W., & Schulte‐Hermann, R. (1995) · Hepatology · doi:10.1002/hep.1840210534 · Cited by 1,223

Modulation of Neuronal Migration by NMDA Receptors

Komuro, H., & RAKIC, P. T. (1993) · Science · doi:10.1126/science.8096653 · Cited by 1,041

GABAA, NMDA and AMPA receptors: a developmentally regulated 'ménage à trois'

Ben‐Ari, Y. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01147-8 · Cited by 807

Nitrative and Oxidative Stress in Toxicology and Disease

Roberts, R. A., Laskin, D. L., Smith, C. V., Robertson, F. M., Allen, E. M. G., Doorn, J. A., & Slikker, W. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp179 · Cited by 257

Effect of Anesthesia on the Developing Brain: Infant and Fetus

Andropoulos, D. B. (2017) · Fetal Diagnosis and Therapy · doi:10.1159/000475928 · Cited by 247

Biochemical, cellular, and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: Lessons learned from the bedside

Kochanek, P. M., Clark, R. S. B., Ruppel, R. A., Adelson, P. D., Bell, M. J., Whalen, M. J., Robertson, C., Satchell, M. A., Seidberg, N. A., Marion, D. W., et al. (2000) · Pediatric Critical Care Medicine · doi:10.1097/00130478-200007000-00003 · Cited by 245

Hypothermic neuroprotection

Gunn, A. J., & Thoresen, M. (2006) · NeuroRx · doi:10.1016/j.nurx.2006.01.007 · Cited by 245

Vulnerability of the developing brain

Bhutta, A. T., & Anand, K. J. S. (2002) · Clinics in Perinatology · doi:10.1016/s0095-5108(02)00011-8 · Cited by 249

Alcoholic neuropathy is clinicopathologically distinct from thiamine‐deficiency neuropathy

Koike, H., Iijima, M., Sugiura, M., Mori, K., Hattori, N., Ito, H., Hirayama, M., & Sobue, G. (2003) · Annals of Neurology · doi:10.1002/ana.10550 · Cited by 242

Ethanol-Induced Caspase-3 Activation in the in Vivo Developing Mouse Brain

Olney, J. W., Tenkova, T. I., Dikranian, K. T., Muglia, L. J., Jermakowicz, W. J., D’Sa-Eipper, C., & Roth, K. A. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0475 · Cited by 240

Xenon and Hypothermia Combine Additively, Offering Long-Term Functional and Histopathologic Neuroprotection After Neonatal Hypoxia/Ischemia

Hobbs, C., Thoresen, M., Tucker, A. M., Aquilina, K., Chakkarapani, E., & Dingley, J. (2008) · Stroke · doi:10.1161/strokeaha.107.499822 · Cited by 241

From genotype to phenotype: A clinical, pathological, and biochemical investigation of frontotemporal dementia and parkinsonism (FTDP-17) caused by the P301L tau mutation

Nasreddine, Z. S., Loginov, M., Clark, L. N., Lamarche, J. B., Miller, B. L., Lamontagne, A., Zhukareva, V. A., Lee, V. M. ‐., Wilhelmsen, K. C., & Geschwind, D. H. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199906)45:6 · Cited by 135

A Pharmacological Model for Psychosis Based on N-methyl-D-aspartate Receptor Hypofunction: Molecular, Cellular, Functional and Behavioral Abnormalities

Rujescu, D., Bender, A., Keck, M. E., Hartmann, A. M., Ohl, F., Ræder, H., Giegling, I., Genius, J., McCarley, R. W., Möller, H., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.029 · Cited by 241

Neurofunctional deficits and potentiated apoptosis by neonatal NMDA antagonist administration

Fredriksson, A., Archer, T., Alm, H., Gordh, T., & Eriksson, P. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.12.026 · Cited by 238

General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain

Lu, L. X., Yon, J. H., Carter, L. B., & Jevtović‐Todorović, V. (2006) · APOPTOSIS · doi:10.1007/s10495-006-8762-3 · Cited by 236

Preconditioning Doses of NMDA Promote Neuroprotection by Enhancing Neuronal Excitability

Soriano, F. X., Papadia, S., Hofmann, F., Hardingham, N. R., Bading, H., & Hardingham, G. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0455-06.2006 · Cited by 236

Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system

Hanslick, J. L., Lau, K., Noguchi, K., Olney, J. W., Zorumski, C. F., Mennerick, S. J., & Farber, N. B. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.11.006 · Cited by 235

The epidemiology and patterns of acute and chronic toxicity associated with recreational ketamine use

Kalsi, S. S., Wood, D. M., & Dargan, P. I. (2011) · Emerging Health Threats Journal · doi:10.3402/ehtj.v4i0.7107 · Cited by 235

Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: implications for schizophrenia

Wang, C., McInnis, J., Ross-Sanchez, M., Shinnick‐Gallagher, P., Wiley, J. L., & Johnson, K. M. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00384-0 · Cited by 234

Postnatal growth and morphological development of the brain: a species comparison

Watson, R. E., DeSesso, J. M., Hurtt, M. E., & Cappon, G. D. (2006) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20090 · Cited by 234

Potentiation of NMDA Receptor Function by the Serine Protease Thrombin

Gingrich, M. B., Junge, C., Lyuboslavsky, P. N., & Traynelis, S. F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04582.2000 · Cited by 231

Comparative Milestones in Rodent and Human Postnatal Central Nervous System Development

Zeiss, C. J. (2021) · Toxicologic Pathology · doi:10.1177/01926233211046933 · Cited by 241

Oxygen causes cell death in the developing brain

Felderhoff‐Mueser, U., Bittigau, P., Sifringer, M., Jarosz, B., Korobowicz, E. M., Mahler, L., Piening, T., Moysich, A., Grune, T., Thor, F., et al. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.07.019 · Cited by 229

NMDA Receptors Activated by Subventricular Zone Astrocytic Glutamate Are Critical for Neuroblast Survival Prior to Entering a Synaptic Network

Platel, J., Dave, K. A., Gordon, V., Lacar, B., Rubio, M. E., & Bordey, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.009 · Cited by 225

Ontogeny of the N-Methyl-D-Aspartate (NMDA) Receptor System and Susceptibility to Neurotoxicity

Haberny, K. A. (2002) · Toxicological Sciences · doi:10.1093/toxsci/68.1.9 · Cited by 218

Ketamine Reduces the Cell Death Following Inflammatory Pain in Newborn Rat Brain

Anand, K. J. S., Garg, S., Rovnaghi, C. R., Narsinghani, U., Bhutta, A. T., & Hall, R. W. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e3180986d2f · Cited by 218

Potential Neurotoxicity of Ketamine in the Developing Rat Brain

Zou, X., Patterson, T. A., Sadovova, N., Twaddle, N. C., Doerge, D. R., Zhang, X., Fu, X., Hanig, J. P., Paule, M. G., Slikker, W., et al. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfn270 · Cited by 221

The cellular and molecular processes associated with scopolamine-induced memory deficit: A model of Alzheimer's biomarkers

Tang, K. S. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116695 · Cited by 223

Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: A challenge for neuroprotection

Puyal, J., Ginet, V., & Clarke, P. G. H. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.03.002 · Cited by 224

Neonatal seizures

Silverstein, F. S., & Jensen, F. E. (2007) · Annals of Neurology · doi:10.1002/ana.21167 · Cited by 216

Apoptotic mechanisms in the pathophysiology of schizophrenia

Jarskog, L. F., Glantz, L. A., Gilmore, J. H., & Lieberman, J. A. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.03.010 · Cited by 219

Anandamide, but not 2‐arachidonoylglycerol, accumulates during in vivo neurodegeneration

Hansen, H. H., Schmid, P. C., Bittigau, P., Lastres‐Becker, I., Berrendero, F., Manzanares, J., Ikonomidou, C., Schmid, H. H. O., Fernández‐Ruiz, J. J., & Hansen, H. S. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00542.x · Cited by 215

Impact of anaesthetics and surgery on neurodevelopment: an update

Sanders, R. D., Hassell, J. K., Davidson, A. J., Robertson, N. J., & Ma, D. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet054 · Cited by 219

The Impact of Age at Surgery on Long-Term Neuropsychological Outcomes in Sagittal Craniosynostosis

Patel, A., Yang, J. F., Hashim, P. W., Travieso, R., Terner, J. S., Mayes, L. C., Kanev, P. M., Duncan, C. C., Jane, J. A., Jane, J. A., et al. (2014) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000000511 · Cited by 212

Isoflurane Causes Greater Neurodegeneration Than an Equivalent Exposure of Sevoflurane in the Developing Brain of Neonatal Mice

Liang, G., Ward, C., Peng, J., Zhao, Y., Huang, B., & Wei, H. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181d94da5 · Cited by 210

Phosphatidylinositol 3‐kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones

Perkinton, M. S., Ip, J. E., Wood, G. L., Crossthwaite, A. J., & Williams, R. J. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00699.x · Cited by 212

Anesthesia for Cesarean Delivery and Learning Disabilities in a Population-based Birth Cohort

Šprung, J., Flick, R. P., Wilder, R. T., Katusic, S. K., Pike, T. L., Dingli, M., Gleich, S. J., Schroeder, D. R., Barbaresi, W. J., Hanson, A. C., et al. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181adf481 · Cited by 205

Newly formed excitatory pathways provide a substrate for hyperexcitability in experimental temporal lobe epilepsy

Esclapez, M., Hirsch, J. C., Ben-Ari, Y., & Bernard, C. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990614)408:4 · Cited by 270

Teratogenic mechanisms of medical drugs

van Gelder, M. M. H. J., van Rooij, I. A. L. M., Miller, R. K., Zielhuis, G. A., den Berg, L. T. W. D. J.-V., & Roeleveld, N. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmp052 · Cited by 210

Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain

Young, C., Klocke, B. J., Tenkova, T. I., Choi, J., Labruyere, J., Qin, Y.-Q., Holtzman, D. M., Roth, K. A., & Olney, J. W. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401277 · Cited by 201

Neonatal Desflurane Exposure Induces More Robust Neuroapoptosis than Do Isoflurane and Sevoflurane and Impairs Working Memory

Kodama, M., Satoh, Y., Otsubo, Y., Araki, Y., Yonamine, R., Masui, K., & Kazama, T. (2011) · Anesthesiology · doi:10.1097/aln.0b013e318234228b · Cited by 201

Excitotoxicity: Still Hammering the Ischemic Brain in 2020

Choi, D. W. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.579953 · Cited by 204

Neurotoxicity of low-level lead exposure: History, mechanisms of action, and behavioral effects in humans and preclinical models

Rocha, A., & Trujillo, K. A. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.02.021 · Cited by 206

Kainic acid-induced seizures produce necrotic, not apoptotic, neurons with internucleosomal DNA cleavage: implications for programmed cell death mechanisms

Fujikawa, D. G., Shinmei, S. S., & Cai, B. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00085-3 · Cited by 198

Ca2+-Permeable AMPA Receptors Induce Phosphorylation of cAMP Response Element-Binding Protein through a Phosphatidylinositol 3-Kinase-Dependent Stimulation of the Mitogen-Activated Protein Kinase Signaling Cascade in Neurons

Perkinton, M. S., Sihra, T. S., & Williams, R. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05861.1999 · Cited by 198

Differential Regulation of Mitogen-Activated Protein Kinases ERK1/2 and ERK5 by Neurotrophins, Neuronal Activity, and cAMP in Neurons

Cavanaugh, J. E., Ham, J., Hetman, M., Poser, S., Yan, C., & Xia, Z. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00434.2001 · Cited by 196

Excitotoxicity: Perspectives Based on N-Methyl-d-Aspartate Receptor Subtypes

Lynch, D. R., & Guttmann, R. P. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.3.717 · Cited by 196

d-glutamate and Gut Microbiota in Alzheimer’s Disease

Chang, C.-H., Lin, C.-H., & Lane, H.-Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082676 · Cited by 191

Death of developing neurons: New insights and implications for connectivity

Dekkers, M. P. J., Nikoletopoulou, V., & Barde, Y. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201306136 · Cited by 204

Ca2+-Permeable AMPA Receptors Regulate Growth of Human Glioblastoma via Akt Activation

Ishiuchi, S., Yoshida, Y., Sugawara, K., Aihara, M., Ohtani, T., Watanabe, T., Saito, N., Tsuzuki, K., Okado, H., Miwa, A., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2180-07.2007 · Cited by 193

Isoflurane and sevoflurane affect cell survival and BCL-2/BAX ratio differently

Wei, H., Kang, B., Wei, W., Liang, G., Meng, Q. C., Li, Y., & Eckenhoff, R. G. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.009 · Cited by 193

New Insights and New Issues in Developmental Neurotoxicology

Olney, J. W. (2002) · NeuroToxicology · doi:10.1016/s0161-813x(01)00092-4 · Cited by 191

Molecular determinants of retinal ganglion cell development, survival, and regeneration

Isenmann, S. (2003) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(03)00027-2 · Cited by 192

Mitochondria: hub of injury responses in the developing brain

Hagberg, H., Mallard, C. E., Rousset, C. I., & Thornton, C. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70261-8 · Cited by 199

RESEARCH ARTICLE: Clinical Anesthesia Causes Permanent Damage to the Fetal Guinea Pig Brain

Rizzi, S., Carter, L. B., Ori, C., & Jevtović‐Todorović, V. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00116.x · Cited by 188

The role of the N-methyl-d-aspartate receptor in ketamine-induced apoptosis in rat forebrain culture

Wang, C., Sadovova, N., Fu, X., Schmued, L. C., Scallet, A. C., Hanig, J. P., & Slikker, W. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.01.053 · Cited by 189

Long‐term consequences of early postnatal seizures on hippocampal learning and plasticity

Lynch, M., Sayın, Ü., Bownds, J., Janumpalli, S., & Sutula, T. P. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00117.x · Cited by 192

Neuronal death enhanced by N -methyl- d -aspartate antagonists

Ikonomidou, C., Stefovska, V. G., & Turski, L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220412197 · Cited by 197

Does general anesthesia affect neurodevelopment in infants and children?

McCann, M. E., & Soriano, S. G. (2019) · BMJ · doi:10.1136/bmj.l6459 · Cited by 187

Blockade of N-Methyl-D-Aspartate Receptors by Ketamine Produces Loss of Postnatal Day 3 Monkey Frontal Cortical Neurons in Culture

Wang, C., Sadovova, N., Hotchkiss, C. E., Fu, X., Scallet, A. C., Patterson, T. A., Hanig, J. P., Paule, M. G., & Slikker, W. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj144 · Cited by 188

Ketamine and phencyclidine: the good, the bad and the unexpected

Lodge, D., & Mercier, M. S. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13222 · Cited by 197

Gray Matters: Fetal Pollution Exposure and Human Capital Formation

Bharadwaj, P., Gibson, M., Zivin, J. G., & Neilson, C. (2017) · Journal of the Association of Environmental and Resource Economists · doi:10.1086/691591 · Cited by 190

NMDA receptors, cognition and schizophrenia – Testing the validity of the NMDA receptor hypofunction hypothesis

Gilmour, G., Dix, S. L., Fellini, L., Gastambide, F., Plath, N., Steckler, T., Talpos, J. C., & Tricklebank, M. D. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.03.015 · Cited by 190

Melatonin reduces the severity of anesthesia-induced apoptotic neurodegeneration in the developing rat brain

Yon, J. H., Carter, L. B., Reiter, R. J., & Jevtović‐Todorović, V. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.08.011 · Cited by 182

Pathological apoptosis in the developing brain

Blomgren, K., Leist, M., & Groc, L. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0754-4 · Cited by 183

Early Alterations of AMPA Receptors Mediate Synaptic Potentiation Induced by Neonatal Seizures

Rakhade, S. N., Zhou, C., Aujla, P. K., Fishman, R. E., Sucher, N. J., & Jensen, F. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1734-08.2008 · Cited by 182

General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain

Sanchez, V., Feinstein, S. D., Lunardi, N., Joksovic, P. M., Boscolo, A., Todorovic, S. M., & Jevtović‐Todorović, V. (2011) · Anesthesiology · doi:10.1097/aln.0b013e3182303a63 · Cited by 182

Sedative and anticonvulsant drugs suppress postnatal neurogenesis

Stefovska, V. G., Uckermann, O., Czuczwar, M., Smitka, M., Czuczwar, P., Kiś, J., Kaindl, A. M., Turski, L., Turski, W. A., & Ikonomidou, C. (2008) · Annals of Neurology · doi:10.1002/ana.21463 · Cited by 180

General Anesthesia Causes Long-Lasting Disturbances in the Ultrastructural Properties of Developing Synapses in Young Rats

Lunardi, N., Ori, C., Erişir, A., & Jevtović‐Todorović, V. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9088-z · Cited by 179

Stroke intervention pathways: NMDA receptors and beyond

Lai, T. W., Shyu, W., & Wang, Y. T. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.12.008 · Cited by 183

Riluzole in the Treatment of Mood and Anxiety Disorders

Pittenger, C., Coric, V., Banasr, M., Bloch, M., Krystal, J. H., & Sanacora, G. (2008) · CNS Drugs · doi:10.2165/00023210-200822090-00004 · Cited by 177

Regulation of Neuronal Cell Death by MST1-FOXO1 Signaling

Yuan, Z., Lehtinen, M. K., Merlo, P., Villén, J., Gygi, S. P., & Bonni, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900461200 · Cited by 178

Glutamate and its receptors in cancer

Stepulak, A., Rola, R., Polberg, K., & Ikonomidou, C. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1182-6 · Cited by 171

Anesthetic Agents and the Immature Brain: Are These Toxic or Therapeutic?

Anand, K. J. S., & Soriano, S. G. (2004) · Anesthesiology · doi:10.1097/00000542-200408000-00033 · Cited by 175

The Dichotomy of NMDA Receptor Signaling

Papadia, S., & Hardingham, G. E. (2007) · The Neuroscientist · doi:10.1177/10738584070130060401 · Cited by 180

Animal models of schizophrenia: a critical review.

Marcotte, E. R., Pearson, D. M., & Srivastava, L. K. (2001) · PubMed Central · Cited by 175

Repeated administration of ketamine may lead to neuronal degeneration in the developing rat brain

Hayashi, H., Dikkes, P., & Soriano, S. G. (2002) · Pediatric Anesthesia · doi:10.1046/j.1460-9592.2002.00883.x · Cited by 174

Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey

Zou, X., Liu, F., Zhang, X., Patterson, T. A., Callicott, R. J., Liu, S., Hanig, J. P., Paule, M. G., Slikker, W., & Wang, C. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2011.06.003 · Cited by 173

Mechanisms leading to disseminated apoptosis following NMDA receptor blockade in the developing rat brain

Hansen, H. H., Briem, T. B., Dzietko, M., Sifringer, M., Voss, A., Rzeski, W., Zdzisińska, B., Thor, F., Heumann, R., Stepulak, A., et al. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.03.013 · Cited by 174

Postoperative cognitive dysfunction after inhalational anesthesia in elderly patients undergoing major surgery: the influence of anesthetic technique, cerebral injury and systemic inflammation

Qiao, Y., Feng, H., Zhao, T., Yan, H., Zhang, H., & Zhao, X. (2015) · BMC Anesthesiology · doi:10.1186/s12871-015-0130-9 · Cited by 170

Influence of the NR3A subunit on NMDA receptor functions

Henson, M. A., Roberts, A. C., Pérez‐Otaño, I., & Philpot, B. D. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.01.004 · Cited by 195

Are anaesthetics toxic to the brain?

Hudson, A. E., & Hemmings, H. C. (2011) · British Journal of Anaesthesia · doi:10.1093/bja/aer122 · Cited by 170

General anesthetics and the developing brain

Istaphanous, G. K., & Loepke, A. W. (2009) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e3283294c9e · Cited by 169

Neuronal Death and Perinatal Lethality in Voltage-Gated Sodium Channel αII-Deficient Mice

Planells‐Cases, R., Caprini, M., Zhang, J., Rockenstein, E. M., Rivera, R. R., Murre, C., Masliah, E., & Montal, M. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76829-9 · Cited by 168

A Rice Glutamate Receptor–Like Gene Is Critical for the Division and Survival of Individual Cells in the Root Apical Meristem

Li, J., Zhu, S., Song, X., Shen, Y., Chen, H., Yu, J., Yi, K., Liu, Y., Karplus, V. J., Wu, P., et al. (2005) · The Plant Cell · doi:10.1105/tpc.105.037713 · Cited by 168

Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated

Hardingham, G. E., & Bading, H. (2002) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/s1570-9639(02)00455-7 · Cited by 178

Anesthesia and neurotoxicity to the developing brain: the clinical relevance

Davidson, A. J. (2011) · Pediatric Anesthesia · doi:10.1111/j.1460-9592.2010.03506.x · Cited by 166

Neurodevelopmental Assessment in Kindergarten in Children Exposed to General Anesthesia before the Age of 4 Years

Graham, M. R., Brownell, M. D., Chateau, D. G., Drăgan, R., Burchill, C. A., & Fransoo, R. R. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001245 · Cited by 168

Pediatric traumatic brain injury: not just little adults

Giza, C. C., Mink, R. B., & Madikians, A. (2007) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e32808255dc · Cited by 164

Apoptosis in the in Vivo Mammalian Forebrain

Dikranian, K. T., Ishimaru, M. J., Tenkova, T. I., Labruyere, J., Qin, Y., Ikonomidou, C., & Olney, J. W. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0411 · Cited by 167

Long‐term behavioural, molecular and morphological effects of neonatal NMDA receptor antagonism

Harris, L. W., Sharp, T., Gartlon, J. E., Jones, D. N. C., & Harrison, P. J. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02902.x · Cited by 162

Use of Analgesic and Sedative Drugs in the NICU: Integrating Clinical Trials and Laboratory Data

Durrmeyer, X., Vutskits, L., Anand, K. J. S., & Rimensberger, P. C. (2010) · Pediatric Research · doi:10.1203/pdr.0b013e3181c8eef3 · Cited by 161

Isoflurane-induced Neuroapoptosis in the Developing Brain of Nonhypoglycemic Mice

Johnson, S. A., Young, C., & Olney, J. W. (2008) · Journal of Neurosurgical Anesthesiology · doi:10.1097/ana.0b013e3181271850 · Cited by 161

Effect of Hypercarbia and Isoflurane on Brain Cell Death and Neurocognitive Dysfunction in 7-day-old Rats

Stratmann, G., May, L. D. V., Sall, J. W., Alvi, R. S., Bell, J. S., Ormerod, B. K., Rau, V., Hilton, J. F., Dai, R., Lee, M. T., et al. (2009) · Anesthesiology · doi:10.1097/aln.0b013e31819c7140 · Cited by 166

Postnatal Phencyclidine Administration Selectively Reduces Adult Cortical Parvalbumin-Containing Interneurons

Wang, C. Z., Yang, S. F., Xia, Y., & Johnson, K. M. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301647 · Cited by 161

Mode of action of taurine as a neuroprotector

Wu, H., Jin, Y. H., Wei, J., Jin, H., Di, S., & Wu, J. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.058 · Cited by 161

NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination

De Biase, L. M., Kang, S. H., Baxi, E. G., Fukaya, M., Pucak, M. L., Mishina, M., Calabresi, P. A., & Bergles, D. E. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2455-11.2011 · Cited by 161

Neurotoxic effects of postnatal thimerosal are mouse strain dependent

Hornig, M., Chian, D., & Lipkin, W. I. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001529 · Cited by 162

Neonatal Seizures: An Update on Mechanisms and Management

Jensen, F. E. (2009) · Clinics in Perinatology · doi:10.1016/j.clp.2009.08.001 · Cited by 160

Transient N-methyl-D-aspartate receptor blockade in early development causes lasting cognitive deficits relevant to schizophrenia

Stefani, M. R., & Moghaddam, B. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.031 · Cited by 157

Specific Targeting of Pro-Death NMDA Receptor Signals with Differing Reliance on the NR2B PDZ Ligand

Soriano, F. X., Martel, M., Papadia, S., Vaslin, A., Baxter, P. S., Rickman, C., Forder, J. P., Tymianski, M., Duncan, R. R., Aarts, M. M., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1207-08.2008 · Cited by 162

Environmental Agents That Have the Potential to Trigger Massive Apoptotic Neurodegeneration in the Developing Brain

Olney, J. W., Farber, N. B., Wozniak, D. F., Jevtović‐Todorović, V., & Ikonomidou, C. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s3383 · Cited by 157

N-Methyl d-Aspartate Receptor-mediated Bidirectional Control of Extracellular Signal-regulated Kinase Activity in Cortical Neuronal Cultures

Chandler, L. J., Sutton, G., Dorairaj, N. R., & Norwood, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m003390200 · Cited by 152

NMDA-induced apoptosis in the developing rat brain

Takai, H., Katayama, K., Yasoshima, A., Uetsuka, K., Nakayama, H., & Doi, K. (2003) · Experimental and Toxicologic Pathology · doi:10.1078/0940-2993-00294 · Cited by 8

Shakespeare in love—with NMDA receptors?

Lipton, S. A., & Nakanishi, N. (1999) · Nature Medicine · doi:10.1038/6481 · Cited by 58

How drugs might damage developing brains

Bradbury, J. (1999) · The Lancet · doi:10.1016/s0140-6736(05)76163-8

Ontogeny of the N-Methyl-D-Aspartate (NMDA) Receptor System and Susceptibility to Neurotoxicity

Haberny, K. A. (2002) · Toxicological Sciences · doi:10.1093/toxsci/68.1.9 · Cited by 218

NMDA receptor activation and apoptosis in developing brain

(1999) · The Neuroscientist · doi:10.1177/107385849900500302