Cited by 2,055Anesthesia and Neurotoxicity ResearchNeuroscience and Neuropharmacology ResearchCell death mechanisms and regulation

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain

Ikonomidou, Chrysanthy, Bosch, Friederike, Miksa, Michael, Bittigau, Petra, Vöckler, Jessica, Dikranian, Krikor, Tenkova, Tanya I., Stefovska, Vanya, Turski, Lechoslaw, Olney, John W.·1999·Science

DOI 10.1126/science.283.5398.70

Open this paper in CoChat — free account

Abstract

Programmed cell death (apoptosis) occurs during normal development of the central nervous system. However, the mechanisms that determine which neurons will succumb to apoptosis are poorly understood. Blockade of N -methyl- d -aspartate (NMDA) glutamate receptors for only a few hours during late fetal or early neonatal life triggered widespread apoptotic neurodegeneration in the developing rat brain, suggesting that the excitatory neurotransmitter glutamate, acting at NMDA receptors, controls neuronal survival. These findings may have relevance to human neurodevelopmental disorders involving prenatal (drug-abusing mothers) or postnatal (pediatric anesthesia) exposure to drugs that block NMDA receptors.

Integrity signals

Registry

Crossref · 10.1126/science.283.5398.70

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444
Cell Death: The Significance of Apoptosis
Wyllie, A. H., Kerr, J. F. R., & Currie, A. R. (1980) · International review of cytology · doi:10.1016/s0074-7696(08)62312-8 · Cited by 7,151
Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90210-0 · Cited by 3,535
RECOGNITION OF THE FETAL ALCOHOL SYNDROME IN EARLY INFANCY
Jones, K., & Smith, D. (1973) · The Lancet · doi:10.1016/s0140-6736(73)91092-1 · Cited by 2,780
Comparative aspects of the brain growth spurt
Dobbing, J., & Sands, J. (1979) · Early Human Development · doi:10.1016/0378-3782(79)90022-7 · Cited by 2,506
Ketamine—its pharmacology and therapeutic uses
white, P. F., Way, W. L., & Trevor, A. J. (1982) · Anesthesiology · doi:10.1097/00000542-198202000-00007 · Cited by 1,474
Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons
Lovinger, D. M., White, G., & Weight, F. F. (1989) · Science · doi:10.1126/science.2467382 · Cited by 1,448
In situ detection of fragmented DNA (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note*1
Kraupp, B. G., Ruttkay-Nedecký, B., Koudelka, H., Bukowska, K., Bursch, W., & Schulte‐Hermann, R. (1995) · Hepatology · doi:10.1002/hep.1840210534 · Cited by 1,223
Modulation of Neuronal Migration by NMDA Receptors
Komuro, H., & RAKIC, P. T. (1993) · Science · doi:10.1126/science.8096653 · Cited by 1,041
GABAA, NMDA and AMPA receptors: a developmentally regulated 'ménage à trois'
Ben‐Ari, Y. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01147-8 · Cited by 807

Show all 33 references

Research works printed but not linked: 5

Cruz-Orive L. L., Weibel E. R., Am. J. Physiol. 258, L148 (1990);
Ishimaru M. J., Ikonomidou C., Dikranian K., Olney J. W., Soc. Neurosci. Abstr. 23, 895 (1997);
Vezzani A., et al., J. Pharmacol. Exp. Ther. 249, 278 (1989);
Valentine J. L., Arnold L. W., Owens S. M., J. Pharmacol. Exp. Ther. 269, 1079 (1994);
White P. F., Marietta M. P., Pudwill C. R., Way W. L., Trevor A. J., J. Pharmacol. Exp. Ther. 196, 545 (1976);

Sorted by citations

Items 501–600 of 1,002

Postnatal intermittent hypoxia alters baroreflex function in adult rats
Soukhova, G. K., Cheng, Z. J., Roberts, A. M., & Gozal, D. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00767.2005 · Cited by 62
Early-life seizures alter synaptic calcium-permeable AMPA receptor function and plasticity
Bell, J. J. L., Zhou, C., Sun, H., Feske, J. S., & Jensen, F. E. (2016) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2016.08.002 · Cited by 62
The Role of D-Amino Acids in Alzheimer’s Disease
Piubelli, L., Murtas, G., Rabattoni, V., & Pollegioni, L. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201217 · Cited by 63
Developmental neurotoxicology
Bondy, S. C., & Campbell, A. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20589 · Cited by 62
Balancing paediatric anaesthesia: preclinical insights into analgesia, hypnosis, neuroprotection, and neurotoxicity
Sanders, R. D., Ma, D., Brooks, P. A., & Maze, M. (2008) · British Journal of Anaesthesia · doi:10.1093/bja/aen263 · Cited by 62
The glutamate-based genetic immune hypothesis in obsessive-compulsive disorder. An integrative approach from genes to symptoms
Rotgé, J., Aouizerate, B., Tignol, J.-P., Bioulac, B. H., Burbaud, P., & Guehl, D. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.10.043 · Cited by 63
Ethanol causes and lithium prevents neuroapoptosis and suppression of pERK in the infant mouse brain
Young, C., Straiko, M. M. W., Johnson, S. A., Creeley, C. E., & Olney, J. W. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.009 · Cited by 61
Self-citation
Isoflurane Impairs Immature Astroglia Development In Vitro: The Role of Actin Cytoskeleton
Lunardi, N., Hucklenbruch, C., Latham, J. R., Scarpa, J. R., & Jevtović‐Todorović, V. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31821284e9 · Cited by 61
Isoflurane suppresses early cortical activity
Ситдикова, Г. Ф., Zakharov, A., Janáčková, S., Gerasimova, E., Lebedeva, J., Inácio, A. R. L., Zaynutdinova, D., Minlebaev, M., Holmes, G. L., & Khazipov, R. (2013) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.16 · Cited by 61
The impact of the perioperative period on neurocognitive development, with a focus on pharmacological concerns
Istaphanous, G. K., Ward, C. G., & Loepke, A. W. (2010) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2010.02.013 · Cited by 60
Effects of the NMDA Antagonist Ketamine on Task-Switching Performance: Evidence for Specific Impairments of Executive Control
Stoet, G., & Snyder, L. H. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300930 · Cited by 61
Repeated Exposure to Anesthetic Ketamine Can Negatively Impact Neurodevelopment in Infants
Yan, J., Li, Y., Zhang, Y., Lu, Y., & Jiang, H. (2014) · Journal of Child Neurology · doi:10.1177/0883073813517508 · Cited by 61
Sex-dependent programming effects of prenatal glucocorticoid treatment on the developing serotonin system and stress-related behaviors in adulthood
Hiroi, R., Carbone, D. L., Zuloaga, D. G., Bimonte‐Nelson, H. A., & Handa, R. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.055 · Cited by 62
The Toxic Effects of S(+)-Ketamine on Differentiating Neurons In Vitro as a Consequence of Suppressed Neuronal Ca2+ Oscillations
Sinner, B., Friedrich, O., Zink, W., Zausig, Y. A., & Graf, B. M. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31822747df · Cited by 61
Overlap in the neural circuitry and molecular mechanisms underlying ketamine abuse and its use as an antidepressant
Kokane, S. S., Armant, R. J., Bolaños‐Guzmán, C. A., & Perrotti, L. I. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112548 · Cited by 63
Alivin 1, a Novel Neuronal Activity-Dependent Gene, Inhibits Apoptosis and Promotes Survival of Cerebellar Granule Neurons
Ono, T., Sekino‐Suzuki, N., Kikkawa, Y., Yonekawa, H., & Kawashima, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05887.2003 · Cited by 61
The protective effects of omega−3 fatty acids against MK-801-induced neurotoxicity in prefrontal cortex of rat
Özyurt, B., Sarsılmaz, M., Akpolat, N., Özyurt, H., Akyol, Ö., Herken, H., & Kuş, İ. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.08.002 · Cited by 60
Effect of Propofol in the Immature Rat Brain on Short- and Long-Term Neurodevelopmental Outcome
Karen, T., Schlager, G. W., Bendix, I., Sifringer, M., Herrmann, R., Pantazis, C., Enot, D. P., Keller, M., Kerner, T., & Felderhoff‐Mueser, U. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064480 · Cited by 61
Nurr1 Protein Is Required for N-Methyl-d-aspartic Acid (NMDA) Receptor-mediated Neuronal Survival
Barneda‐Zahonero, B., Servitja, J., Badiola, N., Miñano-Molina, A. J., Fadó, R., Saura, C. A., & Rodrı́guez-Álvarez, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.272427 · Cited by 60
Small-molecule TrkB agonist 7,8-dihydroxyflavone reverses cognitive and synaptic plasticity deficits in a rat model of schizophrenia
Yang, Y., Li, Y., Wang, W., Wan, J.-G., Yu, B., Mei-zhen, W., & Hu, B. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.03.013 · Cited by 60
The injury response in the term newborn brain: can we neuroprotect?
Hamrick, S. E. G., & Ferriero, D. M. (2003) · Current Opinion in Neurology · doi:10.1097/01.wco.0000063775.81810.79 · Cited by 60
Familial Alzheimer's disease: Site of mutation influences clinical phenotype
Lippa, C. F., Swearer, J. M., Kane, K., Nochlin, D., Bird, T. D., Ghetti, B. F., Nee, L. E., George‐Hyslop, P. S., Pollen, D. A., & Drachman, D. A. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200009)48:3 · Cited by 67
A Fluorescence in Situ Hybridization Map of 6q Deletions in Acute Lymphocytic Leukemia
Sinclair, P. B., Sorour, A., Martineau, M., Harrison, C. J., Mitchell, W. A., O’Neill, E., & Foroni, L. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1871 · Cited by 60
Calcium and activity-dependent signaling in the developing cerebral cortex
Arjun McKinney, A., Petrova, R., & Panagiotakos, G. (2022) · Development · doi:10.1242/dev.198853 · Cited by 55
Mechanism of Neuroprotective Function of Taurine
Wu, J., Wu, H., Jin, Y. H., Wei, J., Di, S., Prentice, H. M., Lee, H.-H., Lin, C.-H., Lee, Y., & Yang, L.-L. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-75681-3_17 · Cited by 60
Transient Effects of Anesthetics on Dendritic Spines and Filopodia in the Living Mouse Cortex
Yang, G., Chang, P. C.-Y., Bekker, A., Blanck, T. J. J., & Gan, W. (2011) · Anesthesiology · doi:10.1097/aln.0b013e318229a660 · Cited by 59
Genes Regulated in Neurons Undergoing Transcription-dependent Apoptosis Belong to Signaling Pathways Rather than the Apoptotic Machinery
Desagher, S., Séverac, D., Липкин, А. В., Bernis, C., Ritchie, W., Digarcher, A. L., & Journot, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408971200 · Cited by 59
Postnatal day 7 ethanol treatment causes persistent reductions in adult mouse brain volume and cortical neurons with sex specific effects on neurogenesis
Coleman, L. G., Oğuz, İ., Lee, J., Styner, M. A., & Crews, F. T. (2012) · Alcohol · doi:10.1016/j.alcohol.2012.01.003 · Cited by 59
N-Methyl-d-aspartate Receptors Regulate a Group of Transiently Expressed Genes in the Developing Brain
Sugiura, N., Patel, R. G., & Corriveau, R. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100011200 · Cited by 59
Confusion between neuronal apoptosis and activation of programmed cell death mechanisms in acute necrotic insults
Fujikawa, D. G. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01601-5 · Cited by 59
Transient blockade of ERK phosphorylation in the critical period causes autistic phenotypes as an adult in mice
Yufune, S., Satoh, Y., Takamatsu, I., Ohta, H., Kobayashi, Y., Takaenoki, Y., Pagès, G., Pouysségur, J., Endo, S., & Kazama, T. (2015) · Scientific Reports · doi:10.1038/srep10252 · Cited by 57
Early Developmental Exposure to Volatile Anesthetics Causes Behavioral Defects in Caenorhabditis elegans
Gentry, K. R., Steele, L. M., Sedensky, M. M., & Morgan, P. G. (2012) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31826d37c5 · Cited by 58
Neurodevelopmental Implications of the Use of Sedation and Analgesia in Neonates
Davidson, A. J., & Flick, R. P. (2013) · Clinics in Perinatology · doi:10.1016/j.clp.2013.05.009 · Cited by 58
NKCC1-Mediated GABAergic Signaling Promotes Postnatal Cell Death in Neocortical Cajal–Retzius Cells
Blanquie, O., Liebmann, L., Hübner, C. A., Luhmann, H. J., & Sinning, A. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw004 · Cited by 63
Homeostatic interplay between electrical activity and neuronal apoptosis in the developing neocortex
Blanquie, O., Kilb, W., Sinning, A., & Luhmann, H. J. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.06.030 · Cited by 61
Acute and long-term proteome changes induced by oxidative stress in the developing brain
Kaindl, A. M., Sifringer, M., Zabel, C., Nebrich, G., Wacker, M. A., Felderhoff‐Mueser, U., Endesfelder, S., von der Hagen, M., Stefovska, V. G., Klose, J., et al. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401796 · Cited by 57
Self-citation
Abnormal cognition and behavior in preterm neonates linked to smaller brain volumes
Bhutta, A. T. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01747-1 · Cited by 58
Inhibition of NMDA receptors induces delayed neuronal maturation and sustained proliferation of progenitor cells during neocortical development
Hirasawa, T., Wada, H., Kohsaka, S., & Uchino, S. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10795 · Cited by 58
Shakespeare in love—with NMDA receptors?
Lipton, S. A., & Nakanishi, N. (1999) · Nature Medicine · doi:10.1038/6481 · Cited by 58
Neurotrophic factor regulation of developing avian oculomotor neurons: Differential effects of BDNF and GDNF
Steljes, T. P. V., Kinoshita, Y., Wheeler, E. F., Oppenheim, R. W., & von Bartheld, C. S. (1999) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19991105)41:2 · Cited by 55
MK-801 Can Exacerbate or Attenuate Behavioral Alterations Associated With Neonatal Alcohol Exposure in the Rat, Depending on the Timing of Administration
Thomas, J. D., Fleming, S. L., & Riley, E. P. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-200105000-00018 · Cited by 58
Glycogen synthase kinase-3 inhibitors prevent caspase-dependent apoptosis induced by ethanol in cultured rat cortical neurons
Takadera, T., & Ohyashiki, T. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.115 · Cited by 58
NMDA neuroprotection against a phosphatidylinositol‐3 kinase inhibitor, LY294002 by NR2B‐mediated suppression of glycogen synthase kinase‐3β‐induced apoptosis
Habas, A., Kharebava, G., Szatmari, E. M., & Hetman, M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03543.x · Cited by 57
Impact of Ketamine on Learning and Memory Function, Neuronal Apoptosis and Its Potential Association with miR-214 and PTEN in Adolescent Rats
Wang, J., Zhou, M., Wang, X., Yang, X., Wang, M.-H., Zhang, C., Zhou, S., & Tang, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099855 · Cited by 57
Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats
Redrobe, J. P., Elster, L., Frederiksen, K., Bundgaard, C., de Jong, I. E. M., Smith, G. P., Bruun, A. T., Larsen, P. H., & Didriksen, M. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2593-9 · Cited by 59
Protective effects of 7-nitroindazole on ketamine-induced neurotoxicity in rat forebrain culture
Wang, C., Sadovova, N., Patterson, T. A., Zou, X., Fu, X., Hanig, J. P., Paule, M. G., Ali, S. F., Zhang, X., & Slikker, W. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2008.03.007 · Cited by 57
Irreversible loss of a subpopulation of cortical interneurons in the absence of glutamatergic network activity
de Lima, A. D., Opitz, T., & Voigt, T. B. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03403.x · Cited by 58
Neuroprotective Effects of Intravenous Anesthetics: A New Critical Perspective
Bilotta, F., Stazi, E., Zlotnik, A. A., Gruenbaum, S. E., & Rosa, G. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140325110113 · Cited by 57
Neurotrophins in the Brain
Boschen, K. E., & Klintsova, A. Y. (2016) · Vitamins and hormones · doi:10.1016/bs.vh.2016.10.008 · Cited by 61
Anesthesia, brain changes, and behavior: Insights from neural systems biology
Colon, É., Bittner, E. A., Kussman, B. D., McCann, M. E., Soriano, S. G., & Borsook, D. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.01.005 · Cited by 58
Systematic review of the pharmacological agents that have been tested against spreading depolarizations
Klass, A., Sánchez-Porras, R., & Santos, E. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18771440 · Cited by 56
Perinatal brain injury and regulation of transcription
Chang, Y., & Huang, C. (2006) · Current Opinion in Neurology · doi:10.1097/01.wco.0000218229.73678.a8 · Cited by 57
NMDA Receptor ActivityIn UteroAverts Respiratory Depression and Anomalous Long-Term Depression in Newborn Mice
Poon, C., Zhou, Z., & Champagnat, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-09-j0003.2000 · Cited by 57
Magnesium induces neuronal apoptosis by suppressing excitability
Dribben, W. H., Eisenman, L. N., & Mennerick, S. J. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.39 · Cited by 55
Drug-Induced Apoptosis: Mechanism by which Alcohol and Many Other Drugs Can Disrupt Brain Development
Creeley, C. E., & Olney, J. W. (2013) · Brain Sciences · doi:10.3390/brainsci3031153 · Cited by 59
Self-citation
Lower Isoflurane Concentration Affects Spatial Learning and Neurodegeneration in Adult Mice Compared with Higher Concentrations
Valentim, A. M., Giminiani, P. D., Ribeiro, P. O., Rodrigues, P., Olsson, I. A. S., & Antunes, L. M. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181f79c7c · Cited by 56
Neonatal Seizures: Do They Damage the Brain?
Thibeault-Eybalin, M., Lortie, A., & Carmant, L. (2009) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2008.10.026 · Cited by 56
Guanfacine Extended Release: A New Pharmacological Treatment Option in Europe
Huß, M., Chen, W., & Ludolph, A. G. (2015) · Clinical Drug Investigation · doi:10.1007/s40261-015-0336-0 · Cited by 60
Metabolism of amino acid neurotransmitters: the synaptic disorder underlying inherited metabolic diseases
Kölker, S. (2018) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-018-0201-4 · Cited by 57
Neuroprotective effect of memantine combined with topiramate in hypoxic–ischemic brain injury
Liu, C., Lin, N., Wu, B., & Qiu, Y. (2009) · Brain Research · doi:10.1016/j.brainres.2009.05.071 · Cited by 56
Neurotoxic effects of dexmedetomidine in fetal cynomolgus monkey brains
Koo, E., Oshodi, T., Meschter, C. L., Ebrahimnejad, A., & Dong, G. (2014) · The Journal of Toxicological Sciences · doi:10.2131/jts.39.251 · Cited by 55
The effects of metabotropic glutamate receptor 7 allosteric agonist N,N′-dibenzhydrylethane-1,2-diamine dihydrochloride on developmental sevoflurane neurotoxicity: role of extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase signaling pathway
Wang, W., Wang, H., Luo, Y., Jia, L., Zhao, J., Zhang, H., Ma, Z., Xue, Q.-S., & Yu, B. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.039 · Cited by 55
Location- and Subunit-Specific NMDA Receptors Determine the Developmental Sevoflurane Neurotoxicity Through ERK1/2 Signaling
Wang, W., Jia, L., Luo, Y., Zhang, H., Cai, F., Mao, H., Xu, W., Fang, J., Peng, Z., Ma, Z., et al. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9005-1 · Cited by 56
Activated Src kinases interact with the N‐methyl‐ D ‐aspartate receptor after neonatal brain ischemia
Jiang, X., Mu, D., Biran, V., Faustino, J. V., Chang, S., Rincón, C. M., Sheldon, R. A., & Ferriero, D. M. (2008) · Annals of Neurology · doi:10.1002/ana.21365 · Cited by 55
Ketamine-induced oxidative stress at different developmental stages of zebrafish (Danio rerio) embryos
Félix, L. M., Vidal, A. M., Serafim, C., Valentim, A. M., Antunes, L. M., Campos, S., Matos, M., Monteiro, S. M., & Coimbra, A. M. (2016) · RSC Advances · doi:10.1039/c6ra08298j · Cited by 55
Behavioral alterations of zebrafish larvae after early embryonic exposure to ketamine
Félix, L. M., Antunes, L. M., Coimbra, A. M., & Valentim, A. M. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4491-7 · Cited by 55
Improvement of autistic-like behaviors in adult rats prenatally exposed to valproic acid through early suppression of NMDA receptor function
Mohammadi, S., Asadi‐Shekaari, M., Basiri, M., Parvan, M., Shabani, M., & Nozari, M. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05357-2 · Cited by 57
D‐serine in the developing human central nervous system
Fuchs, S. A., DORLAND, L., der Velden, M. G. M. D. S., Hendriks, M. M. W. B., Klomp, L. W. J., Berger, R., & de Koning, T. J. (2006) · Annals of Neurology · doi:10.1002/ana.20977 · Cited by 55
N‐methyl‐D‐aspartate receptor agonists modulate homocysteine‐induced developmental abnormalities
Rosenquist, T. H., Schneider, A. M., & Monaghan, D. T. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.12.1523 · Cited by 55
NMDA Receptors: Distribution, Role, and Insights into Neuropsychiatric Disorders
Beaurain, M., Salabert, A., Payoux, P., Gras, E., & Talmont, F. (2024) · Pharmaceuticals · doi:10.3390/ph17101265 · Cited by 57
A two-hit model: behavioural investigation of the effect of combined neonatal MK-801 administration and isolation rearing in the rat
Lim, A. L., TAYLOR, D. A. H. B., & Malone, D. T. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111430751 · Cited by 54
General Anesthesia
Vutskits, L. (2012) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31826a1178 · Cited by 54
Anesthetics and brain toxicity
Soriano, S. G., & Anand, K. J. S. (2005) · Current Opinion in Anaesthesiology · doi:10.1097/01.aco.0000169238.36927.c2 · Cited by 56
Effects of gestational isoflurane exposure on postnatal memory and learning in rats
Kong, F., Xu, L., He, D., Zhang, X., & Lu, H.-S. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.08.050 · Cited by 54
Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway
Forrest, C. M., Khalil, O. S., Pisar, M., McNair, K., Kornisiuk, E. E., Snitcofsky, M., Gonzalez, N., Jerusalinsky, D. A., Darlington, L. G., & Stone, T. W. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.09.034 · Cited by 56
A Minimally Invasive, Translational Biomarker of Ketamine-Induced Neuronal Death in Rats: microPET Imaging Using 18F-Annexin V
Zhang, X., Paule, M. G., Newport, G. D., Zou, X., Sadovova, N., Berridge, M. S., Apana, S. M., Hanig, J. P., Slikker, W., & Wang, C. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp167 · Cited by 54
Repeated ketamine administration alters N -methyl- d -aspartic acid receptor subunit gene expression: Implication of genetic vulnerability for ketamine abuse and ketamine psychosis in humans
Xu, K., & Lipsky, R. H. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214549531 · Cited by 54
Risk of autistic disorder after exposure to general anaesthesia and surgery
Ko, W., Huang, J., Chiang, Y.-C., Nfor, O. N., Ko, P., Jan, S., Lung, C.-C., Chang, H., Lin, L., & Liaw, Y. (2014) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000000130 · Cited by 56
N -Methyl-D-Aspartate (NMDA) receptor modulators: a patent review (2015-present)
Ahmed, H., Haider, A., & Ametamey, S. M. (2020) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2020.1811234 · Cited by 59
Ketamine analgesia for inflammatory pain in neonatal rats: a factorial randomized trial examining long-term effects
Rovnaghi, C. R., Garg, S., Hall, R. W., Bhutta, A. T., & Anand, K. J. S. (2008) · Behavioral and Brain Functions · doi:10.1186/1744-9081-4-35 · Cited by 54
Chemogenetic Activation of Prefrontal Cortex in Shank3-Deficient Mice Ameliorates Social Deficits, NMDAR Hypofunction, and Sgk2 Downregulation
Qin, L., Ma, K., & Yan, Z. (2019) · iScience · doi:10.1016/j.isci.2019.06.014 · Cited by 51
Anesthesia complications of pediatric radiation therapy
Verma, V., Beethe, A. B., LeRiger, M. M., Kulkarni, R. R., Zhang, M., & Lin, C. H. (2015) · Practical Radiation Oncology · doi:10.1016/j.prro.2015.10.018 · Cited by 55
Neonatal exposure to MK-801, an N-methyl-d-aspartate receptor antagonist, enhances methamphetamine-induced locomotion and disrupts sensorimotor gating in pre- and postpubertal rats
Uehara, T., Sumiyoshi, T., Seo, T., Matsuoka, T., Itoh, H., Suzuki, M., & Kurachi, M. (2010) · Brain Research · doi:10.1016/j.brainres.2010.07.013 · Cited by 53
Enhanced NMDA receptor tyrosine phosphorylation and increased brain injury following neonatal hypoxia–ischemia in mice with neuronal Fyn overexpression
Knox, R. N., Zhao, C., Miguel-Perez, D., Wang, S., Yuan, J., Ferriero, D. M., & Jiang, X. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.10.024 · Cited by 53
Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia—sub-chronic and early postnatal PCP treatment in attentional set-shifting
Broberg, B. V., Glenthoj, B. Y., Dias, R., Larsen, D. B., & Olsen, C. K. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1540-5 · Cited by 53
Risperidone reverses phencyclidine induced decrease in glutathione levels and alterations of antioxidant defense in rat brain
Stojković, T., Radonjić, N. V., Velimirović, M., Jevtić, G., POPOVIC, V. M., Doknić, M., & Petronijević, N. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.06.013 · Cited by 53
Oral Clefts and Academic Performance in Adolescence: The Impact of Anesthesia-Related Neurotoxicity, Timing of Surgery, and Type of Oral Clefts
Clausen, N. G., Pedersen, D. A., Pedersen, J. K., Møller, S. E., Grosen, D. W., Christensen, K., Hansen, T. G., & Wehby, G. L. (2016) · The Cleft Palate-Craniofacial Journal · doi:10.1597/15-185 · Cited by 53
The great barrier belief: The blood–brain barrier and considerations for juvenile toxicity studies
Schmitt, G., Parrott, N. J., Prinssen, E. P. M., & Barrow, P. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2017.06.043 · Cited by 56
Management of acute pain and anxiety in children undergoing procedures in the emergency department
KRAUSS, B. S. (2001) · Pediatric Emergency Care · doi:10.1097/00006565-200104000-00010 · Cited by 53
Nitrous oxide: are we still in equipoise? A qualitative review of current controversies
de Vasconcellos, K., & Sneyd, J. R. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet215 · Cited by 52
NMDA receptor couples Rac1-GEF Tiam1 to direct oligodendrocyte precursor cell migration
Xiao, L., Hu, C., Yang, W., Guo, D., Li, C., Shen, W., Liu, X., Aijun, H., Wang, D., & He, C. (2013) · Glia · doi:10.1002/glia.22578 · Cited by 51
Gap Junctions Are Required for NMDA Receptor–Dependent Cell Death in Developing Neurons
Vaccari, J. C. D. R., Corriveau, R. A., & Belousov, A. B. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00362.2007 · Cited by 53
NMDA and benzodiazepine receptors have synergistic and antagonistic effects on precursor cells in adult hippocampal neurogenesis
Petrus, D. S., Fabel, K. S., Kronenberg, G., Winter, C., Steiner, B., & Kempermann, G. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06579.x · Cited by 52
A “double hit” murine model for schizophrenia shows alterations in the structure and neurochemistry of the medial prefrontal cortex and the hippocampus
Gilabert‐Juan, J., Bellés, M., Sáez-Ibáñez, A. R., Carceller, H., Zamarbide-Forés, S., Moltó, M. D., & Nácher, J. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.07.008 · Cited by 56
Identification of differentially expressed genes according to chemosensitivity in advanced ovarian serous adenocarcinomas: expression of GRIA2 predicts better survival
Choi, C. H., Choi, J.-J., Park, Y. H., Lee, Y.-Y., Song, S. Y., Sung, C. O., Song, T., Kim, M. K., Kim, T.-J., Lee, J., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.217 · Cited by 52
Blockade of ionotropic glutamate receptors produces neuronal apoptosis through the Bax‐cytochrome C‐caspase pathway: the causative role of Ca2+ deficiency
Yoon, W. J., Won, S. J., Ryu, B. R., & Gwag, B. J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01724.x · Cited by 52
Cobalt( ii )-catalyzed remote C5-selective C–H sulfonylation of quinolines via insertion of sulfur dioxide
Wang, K., Wang, G., Duan, G., & Xia, C. (2017) · RSC Advances · doi:10.1039/c7ra11363c · Cited by 51
Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine
Forrest, C. M., McNair, K., Pisar, M., Khalil, O. S., Darlington, L. G., & Stone, T. W. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.022 · Cited by 51
Experimental Mild Traumatic Brain Injury Induces Functional Alteration of the Developing Hippocampus
Yu, Z., & Morrison, B. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00775.2009 · Cited by 50
Comparison of the deleterious effects of binge drinking‐like alcohol exposure in adolescent and adult mice
Lacaille, H., Duterte‐Boucher, D., Liot, D., Vaudry, H., Naassïla, M., & Vaudry, D. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.13020 · Cited by 51

Authors: Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vöckler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L., & Olney, J. W.
Affiliations: Washington University in St. Louis (US)
C. Ikonomidou, F. Bosch, M. Miksa, P. Bittigau, J. Vöckler, V. Stefovska, Department of Pediatric Neurology, Charité-Virchow Clinics, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany. K. Dikranian, T. I. Tenkova, J. W. Olney, Department of Psychiatry, Washington University School of Medicine, 4940 Children's Place, St. Louis, MO 63110, USA. L. Turski, Eisai London Research Laboratories, Bernard Katz Building, University College London, Gower Street, London WC1E 6BT, UK.
Corresponding author: Ikonomidou, Chrysanthy
ORCID: Ikonomidou, Chrysanthy
Bittigau, Petra
Dikranian, Krikor
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1999-01
Volume: 283
Issue: 5398
Pages: 70-74
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.283.5398.70
OpenAlex: W2036650593
Cited by: 2,055
References: 33
Citations by year: 2026: 17 · 2025: 36 · 2024: 41 · 2023: 43 · 2022: 49 · 2021: 73 · 2020: 63 · 2019: 148 · 2018: 85 · 2017: 86 · 2016: 112 · 2015: 98 · 2014: 94 · 2013: 92 · 2012: 92
FWCI: 13.19
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k05mh038894-20)
National Institute on Aging (AG11355, P01AG011355)
National Institute of Mental Health (MH-38894)
National Institute on Drug Abuse (R01DA005072, DA05072)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: NMDA receptor blockade, apoptosis, neuronal survival, glutamate excitotoxicity, brain development, fetal brain development, neonatal brain development, neurodevelopmental disorders, prenatal drug exposure, pediatric anesthesia, excitatory neurotransmitter
MeSH terms: Animals, Brain, Calcium Channel Blockers, Dose-Response Relationship, Drug, Fetus, Haloperidol, Immunohistochemistry, Microscopy, Electron, Nerve Degeneration, Neurons, Quinoxalines, Scopolamine, Receptors, N-Methyl-D-Aspartate, Dizocilpine Maleate, Apoptosis, Dopamine Antagonists, Excitatory Amino Acid Antagonists, Muscarinic Antagonists, In Situ Nick-End Labeling, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks