The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Chlamydia Infections and Heart Disease Linked Through Antigenic Mimicry
Abstract
Chlamydia infections are epidemiologically linked to human heart disease. A peptide from the murine heart muscle–specific α myosin heavy chain that has sequence homology to the 60-kilodalton cysteine-rich outer membrane proteins of Chlamydia pneumoniae , C. psittaci , and C. trachomatis was shown to induce autoimmune inflammatory heart disease in mice. Injection of the homologous Chlamydia peptides into mice also induced perivascular inflammation, fibrotic changes, and blood vessel occlusion in the heart, as well as triggering T and B cell reactivity to the homologous endogenous heart muscle–specific peptide. Chlamydia DNA functioned as an adjuvant in the triggering of peptide-induced inflammatory heart disease. Infection with C. trachomatis led to the production of autoantibodies to heart muscle–specific epitopes. Thus, Chlamydia -mediated heart disease is induced by antigenic mimicry of a heart muscle–specific protein.
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Cites
Prediction of coronary heart disease using risk factor categories
Wilson, P. W. F., D’Agostino, R. B., Levy, D., Belanger, A. M., Silbershatz, H., & Kannel, W. B. (1998) · Circulation · doi:10.1161/01.cir.97.18.1837 · Cited by 9,581
CpG motifs in bacterial DNA trigger direct B-cell activation
Krieg, A. M., Yi, A.-K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A., & Klinman, D. M. (1995) · Nature · doi:10.1038/374546a0 · Cited by 3,508
Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice.
Pummerer, C. L., Luze, K., Grässl, G., Bachmaier, K., Offner, F., Burrell, S. K., Lenz, D. M., Zamborelli, T. J., Penninger, J. M., & Neu, N. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118642 · Cited by 205
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Cited by
DNA Vaccines: Immunology, Application, and Optimization
Gurunathan, S., Klinman, D. M., & Seder, R. A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.927 · Cited by 1,207
Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39
Read, T. D. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.6.1397 · Cited by 772
Autoimmune disease: why and where it occurs
Marrack, P., Kappler, J., & Kotzin, B. L. (2001) · Nature Medicine · doi:10.1038/90935 · Cited by 609
Mechanisms for the induction of autoimmunity by infectious agents
Wucherpfennig, K. W. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14235 · Cited by 435
Eriksson, U., Ricci, R., Hunziker, L., Kurrer, M. O., Oudit, G. Y., Watts, T. H., Sonderegger, I., Bachmaier, K., Kopf, M., & Penninger, J. M. (2003) · Nature Medicine · doi:10.1038/nm960 · Cited by 405
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Metadata
- Authors
- Bachmaier, K., Neu, N., de la Maza, L. M., Pal, S., Hessel, A., & Penninger, J. M.
- Venue
- Science
- Published
- 1999-02-26
- Volume
- 283
- Issue
- 5406
- Pages
- 1335-1339
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2030562643
- Cited by
- 419
- References
- 3
- FWCI
- 19.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bachmaier, K., Neu, N., de la Maza, L. M., Pal, S., Hessel, A., & Penninger, J. M. (1999). Chlamydia Infections and Heart Disease Linked Through Antigenic Mimicry. Science. https://doi.org/10.1126/science.283.5406.1335
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