The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
Abstract
The antifungal defense of Drosophila is controlled by the spaetzle/Toll/cactus gene cassette. Here, a loss-of-function mutation in the gene encoding a blood serine protease inhibitor, Spn43Ac, was shown to lead to constitutive expression of the antifungal peptide drosomycin, and this effect was mediated by the spaetzle and Toll gene products. Spaetzle was cleaved by proteolytic enzymes to its active ligand form shortly after immune challenge, and cleaved Spaetzle was constitutively present in Spn43Ac -deficient flies. Hence, Spn43Ac negatively regulates the Toll signaling pathway, and Toll does not function as a pattern recognition receptor in the Drosophila host defense.
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Citations
Cites
A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway
Belvin, M. P., & Anderson, K. V. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.393 · Cited by 836
Cited by
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
Schneider, D. S., & Ayres, J. S. (2008) · Nature Reviews Immunology · doi:10.1038/nri2432 · Cited by 783
Metadata
- Authors
- Levashina, E. A., Langley, E., Green, C., Gubb, D., Ashburner, M., Hoffmann, J. A., & Reichhart, J.-M.
- Venue
- Science
- Published
- 1999-09-17
- Volume
- 285
- Issue
- 5435
- Pages
- 1917-1919
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1963984736
- Cited by
- 436
- References
- 1
- FWCI
- 11.22
- Type
- journal article
- Language
- en
- Open access
- closed
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