The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
Abstract
The antifungal defense of Drosophila is controlled by the spaetzle/Toll/cactus gene cassette. Here, a loss-of-function mutation in the gene encoding a blood serine protease inhibitor, Spn43Ac, was shown to lead to constitutive expression of the antifungal peptide drosomycin, and this effect was mediated by the spaetzle and Toll gene products. Spaetzle was cleaved by proteolytic enzymes to its active ligand form shortly after immune challenge, and cleaved Spaetzle was constitutively present in Spn43Ac -deficient flies. Hence, Spn43Ac negatively regulates the Toll signaling pathway, and Toll does not function as a pattern recognition receptor in the Drosophila host defense.
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Citations
Cites
A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway
Belvin, M. P., & Anderson, K. V. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.393 · Cited by 836
Cited by
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
Schneider, D. S., & Ayres, J. S. (2008) · Nature Reviews Immunology · doi:10.1038/nri2432 · Cited by 783
Innate immune recognition of the microbiota promotes host-microbial symbiosis
Chu, H., & Mazmanian, S. K. (2013) · Nature Immunology · doi:10.1038/ni.2635 · Cited by 630
Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling
Weber, A. N. R., Tauszig-Delamasure, S., Hoffmann, J. A., Lelièvre, E., Gascan, H., Ray, K. P., Morse, M. A., Imler, J.-L., & Gay, N. J. (2003) · Nature Immunology · doi:10.1038/ni955 · Cited by 469
Self-citationDorsoventral Axis Formation in the Drosophila Embryo—Shaping and Transducing a Morphogen Gradient
Moussian, B., & Roth, S. (2005) · Current Biology · doi:10.1016/j.cub.2005.10.026 · Cited by 245
Spatial Regulation of Developmental Signaling by a Serpin
Hashimoto, C., Kim, D. R., Weiss, L. A., Miller, J. W., & Morisato, D. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00338-1 · Cited by 79
Metadata
- Authors
- Levashina, E. A., Langley, E., Green, C., Gubb, D., Ashburner, M., Hoffmann, J. A., & Reichhart, J.-M.
- Venue
- Science
- Published
- 1999-09-17
- Volume
- 285
- Issue
- 5435
- Pages
- 1917-1919
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1963984736
- Cited by
- 436
- References
- 1
- FWCI
- 11.22
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
