The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
DNA Topoisomerase IIβ and Neural Development
Abstract
DNA topoisomerase IIβ is shown to have an unsuspected and critical role in neural development. Neurogenesis was normal in IIβ mutant mice, but motor axons failed to contact skeletal muscles, and sensory axons failed to enter the spinal cord. Despite an absence of innervation, clusters of acetylcholine receptors were concentrated in the central region of skeletal muscles, thereby revealing patterning mechanisms that are autonomous to skeletal muscle. The defects in motor axon growth in IIβ mutant mice resulted in a breathing impairment and death of the pups shortly after birth.
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Cites
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Self-citationDEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION
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The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo
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Self-citationEarly stages of chick somite development
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DNA topoisomerase II is required at the time of mitosis in yeast
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Self-citationDil and DiO: versatile fluorescent dyes for neuronal labelling and pathway tracing
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DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe
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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis
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Self-citation
Cited by
DNA Topoisomerases: Structure, Function, and Mechanism
Champoux, J. J. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.369 · Cited by 2,743
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology
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Topoisomerases as anticancer targets
Delgado, J. L., Hsieh, C.-M., Chan, N.-L., & Hiasa, H. (2018) · Biochemical Journal · doi:10.1042/bcj20160583 · Cited by 481
The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing
Deweese, J. E., & Osheroff, N. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn937 · Cited by 462
Genome Organization Drives Chromosome Fragility
Canela, A., Maman, Y., Jung, S., Wong, N., Callen, E., Day, A., Kieffer-Kwon, K.-R., Pekowska, A., Zhang, H., Rao, S. S. P., et al. (2017) · Cell · doi:10.1016/j.cell.2017.06.034 · Cited by 383
Metadata
- Authors
- Yang, X., Li, W., Prescott, E. D., Burden, S. J., & Wang, J. C.
- Venue
- Science
- Published
- 2000-01-07
- Volume
- 287
- Issue
- 5450
- Pages
- 131-134
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2060963038
- Cited by
- 344
- References
- 20
- FWCI
- 7.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, X., Li, W., Prescott, E. D., Burden, S. J., & Wang, J. C. (2000). DNA Topoisomerase IIβ and Neural Development. Science. https://doi.org/10.1126/science.287.5450.131
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
