The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
ACCESSIBILITY CONTROL OF ANTIGEN-RECEPTOR VARIABLE-REGION GENE ASSEMBLY: Role of cis-Acting Elements
Abstract
▪ Abstract Antigen receptor variable region genes are assembled from germline variable (V), diversity (D), and joining (J) gene segments. This process requires expression of V(D)J recombinase activity, and “accessibility” of variable gene segments to this recombinase. The exact mechanism by which variable gene segments become accessible during development is not known. However, several studies have shown that cis-acting elements that regulate transcription may also function to regulate accessibility. Here we review the evidence that transcriptional promoters, enhancers, and silencers are involved in regulation of accessibility. The manner in which these elements may combine to regulate accessibility is addressed. In addition, current and potential strategies for identifying and analyzing cis-acting elements that mediate locus accessibility are discussed.
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Two Pairs of Recombination Signals Are Sufficient to Cause Immunoglobulin V-(D)-J Joining
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Yin Yang 1 is a critical regulator of B-cell development
Liu, H., Schmidt-Supprian, M., Shi, Y., Hobeika, E., Barteneva, N., Jumaa, H., Pelanda, R., Reth, M., Skok, J., Rajewsky, K., et al. (2007) · Genes & Development · doi:10.1101/gad.1529307 · Cited by 264
Landree, M. A., Wibbenmeyer, J. A., & Roth, D. B. (1999) · Genes & Development · doi:10.1101/gad.13.23.3059 · Cited by 209
Factors and forces controlling V(D) J recombination
Hesslein, D. G. T., & Schatz, D. G. (2001) · Advances in immunology · doi:10.1016/s0065-2776(01)78004-2 · Cited by 183
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Metadata
- Authors
- Sleckman, B. P., Gorman, J. R., & Alt, F. W.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1996-04
- Volume
- 14
- Issue
- 1
- Pages
- 459-481
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2139711308
- Cited by
- 290
- References
- 4
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sleckman, B. P., Gorman, J. R., & Alt, F. W. (1996). ACCESSIBILITY CONTROL OF ANTIGEN-RECEPTOR VARIABLE-REGION GENE ASSEMBLY: Role of cis-Acting Elements. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.14.1.459
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