Cited by 394Fungal and yeast genetics researchProtein Kinase Regulation and GTPase SignalingGenomics and Chromatin Dynamics

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A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control

Odom, Audrey R., Stahlberg, Alke, Wente, Susan R., York, John D.·2000·Science

DOI 10.1126/science.287.5460.2026

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Abstract

Phospholipase C and two inositol polyphosphate (IP) kinases constitute a signaling pathway that regulates nuclear messenger RNA export through production of inositol hexakisphosphate (IP 6 ). The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae , designated Ipk2, was found to be identical to Arg82, a regulator of the transcriptional complex ArgR-Mcm1. Synthesis of inositol 1,4,5,6-tetrakisphosphate, but not IP 6 , was required for gene regulation through ArgR-Mcm1. Thus, the phospholipase C pathway produces multiple IP messengers that modulate distinct nuclear processes. The results reveal a direct mechanism by which activation of IP signaling may control gene expression.

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Authors: Odom, A. R., Stahlberg, A., Wente, S. R., & York, J. D.
Affiliations: Departments of Pharmacology and Cancer Biology and of Biochemistry, Duke University Medical Center, DUMC 3813, Durham, NC 27710, USA.
Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid, St. Louis, MO 63110, USA.
Washington University in St. Louis (US)
Duke University (US)
Corresponding author: York, John D.
ORCID: Wente, Susan R.
York, John D.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2000-03-17
Volume: 287
Issue: 5460
Pages: 2026-2029
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.287.5460.2026
OpenAlex: W2087358641
Cited by: 394
References: 39
Citations by year: 2026: 5 · 2025: 8 · 2024: 8 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 10 · 2019: 11 · 2018: 6 · 2017: 13 · 2016: 13 · 2015: 17 · 2014: 6 · 2013: 11 · 2012: 21
FWCI: 10.49
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: phytic acid, mRNA export, transcriptional regulation, Saccharomyces cerevisiae, gene expression regulation
MeSH terms: Amino Acid Sequence, Arginine, Cell Nucleus, DNA-Binding Proteins, Inositol Phosphates, Molecular Sequence Data, Type C Phospholipases, Phosphoric Monoester Hydrolases, Phosphorylation, Phytic Acid, Saccharomyces cerevisiae, Transcription Factors, Transcription, Genetic, Signal Transduction, Inositol 1,4,5-Trisphosphate, Gene Expression Regulation, Fungal, Phosphotransferases (Alcohol Group Acceptor), Minichromosome Maintenance 1 Protein

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A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control

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