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A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control
Abstract
Phospholipase C and two inositol polyphosphate (IP) kinases constitute a signaling pathway that regulates nuclear messenger RNA export through production of inositol hexakisphosphate (IP 6 ). The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae , designated Ipk2, was found to be identical to Arg82, a regulator of the transcriptional complex ArgR-Mcm1. Synthesis of inositol 1,4,5,6-tetrakisphosphate, but not IP 6 , was required for gene regulation through ArgR-Mcm1. Thus, the phospholipase C pathway produces multiple IP messengers that modulate distinct nuclear processes. The results reveal a direct mechanism by which activation of IP signaling may control gene expression.
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In the citing paper
“Odom et al showed that Arg82 is an inositol phosphate kinase that converts Ins(1,4,5)P3 to Ins(1,4,5,6)P4 and that kinase activity is required for its role in transcriptional regulation (figure 5d)36.”
From Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate (2012) · cites this paper as [36]
In the citing paper
“This study revealed that IPK2 (yeast IPMK) enhances DNA binding of the ArgR-MCM1 complex independently of its kinase activity.”
From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [73]
In the citing paper
“However, the transcriptional function of this complex is regulated by InsP4 and InsP5, which are products of IPK2’s kinase activity.”
From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [73]
In the citing paper
“The York group demonstrated that InsP4 (Ins 1, 4, 5, 6) is crucial for activating the ArgR-MCM1 transcription factor in yeast [73], which regulates genes involved in cell cycle, cell type specificity, and responses to pheromones and nutrients.”
From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [73]
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Metadata
- Authors
- Odom, A. R., Stahlberg, A., Wente, S. R., & York, J. D.
- Affiliations
- Departments of Pharmacology and Cancer Biology and of Biochemistry, Duke University Medical Center, DUMC 3813, Durham, NC 27710, USA.
- Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid, St. Louis, MO 63110, USA.
- Washington University in St. Louis (US)
- Duke University (US)
- Corresponding author
- York, John D.
- Venue
- Science
- Published
- 2000-03-17
- Volume
- 287
- Issue
- 5460
- Pages
- 2026-2029
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2087358641
- Cited by
- 394
- References
- 39
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 8 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 10 · 2019: 11 · 2018: 6 · 2017: 13 · 2016: 13 · 2015: 17 · 2014: 6 · 2013: 11 · 2012: 21
- FWCI
- 10.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- phytic acid, mRNA export, transcriptional regulation, Saccharomyces cerevisiae, gene expression regulation
- MeSH terms
- Amino Acid Sequence, Arginine, Cell Nucleus, DNA-Binding Proteins, Inositol Phosphates, Molecular Sequence Data, Type C Phospholipases, Phosphoric Monoester Hydrolases, Phosphorylation, Phytic Acid, Saccharomyces cerevisiae, Transcription Factors, Transcription, Genetic, Signal Transduction, Inositol 1,4,5-Trisphosphate, Gene Expression Regulation, Fungal, Phosphotransferases (Alcohol Group Acceptor), Minichromosome Maintenance 1 Protein
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