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Comparative Genomics of the Eukaryotes
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A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.
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“To our knowledge, this is the first genome-wide survey and comparison of conserved elements in different groups of eukaryotic species (excluding comparisons primarily of proteomes; e.g., Rubin et al. 2000).”
From Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes (2005) · cites this paper as Rubin et al. 2000
In the citing paper
“Comparisons (4-6) between fruit fly, nematode, and vertebrate genomes reveal greater genomic complexity in the vertebrates (and other deuterostomes (7,8)) as measured by gene content and structure, but at the same time show that many genes and networks are shared across bilaterians.”
From Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization (2007) · cites this paper as [4]
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Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289
Self-citationThe Genome Sequence of Drosophila melanogaster
Adams, M. D., Celniker, S., Holt, R. A., Evans, C. A., Gocayne, J. D., Amanatides, P. G., Scherer, S. E., Li, P. W., Hoskins, R. A., Galle, R. F., et al. (2000) · Science · doi:10.1126/science.287.5461.2185 · Cited by 5,902
Self-citationWhole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd
Fleischmann, R. D., Adams, M. D., White, O. R., Clayton, R. A., Kirkness, E. F., Kerlavage, A. R., Bult, C. J., Tomb, J.-F., Dougherty, B. A., Merrick, J. M., et al. (1995) · Science · doi:10.1126/science.7542800 · Cited by 5,731
Self-citationInduction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
Liu, X., Kim, C. N., Yang, J., Jemmerson, R., & Wang, X. (1996) · Cell · doi:10.1016/s0092-8674(00)80085-9 · Cited by 5,167
Genome Sequence of the Nematode C. elegans : A Platform for Investigating Biology
Berg, J. (1998) · Science · doi:10.1126/science.282.5396.2012 · Cited by 4,458
Goffeau, A., Barrell, B. G., Bussey, H., Davis, R. W., Dujon, B., Feldmann, H., Galibert, F., Hoheisel, J. D., Jacq, C., Johnston, M., et al. (1996) · Science · doi:10.1126/science.274.5287.546 · Cited by 4,423
Molecular characterization of mitochondrial apoptosis-inducing factor
Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., et al. (1999) · Nature · doi:10.1038/17135 · Cited by 4,060
BCL-2 family members and the mitochondria in apoptosisPreprint
Gross, A., McDonnell, J. M., & Korsmeyer, S. J. (1999) · Genes & Development · doi:10.1101/gad.13.15.1899 · Cited by 3,642
The SWISS-PROT protein sequence data bank and its supplement TrEMBL
Bairoch, A., & Apweiler, R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.1.31 · Cited by 3,594
Self-citationThe SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1998
Bairoch, A. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.1.38 · Cited by 3,275
Flagged first, then by citations
1 of the 87 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
- K. Weber in (29) pp. 291–293.
- Blaumueller C. M., Artavanis-Tsakonas S., Perspect. Dev. Neurobiol. 4, 325 (1997);
- Park A. G., Trends Cell Biol. 10, 394 (2000);
- Miklos G. L. G., J. Am. Acad. Arts Sci. 127, 197 (1998).
- See www.sciencemag.org/feature/data/1049664.shl for complete protein domain analysis.
Cited by
Sorted by citations
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alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.
Südhof, T. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.933 · Cited by 215
Duplicate genes increase gene expression diversity within and between species
Gu, Z., Rifkin, S. A., White, K. P., & Li, W. (2004) · Nature Genetics · doi:10.1038/ng1355 · Cited by 200
Reece-Hoyes, J. S., Deplancke, B., Shingles, J., Grove, C. A., Hope, I. A., & Walhout, A. J. M. (2005) · Genome biology · doi:10.1186/gb-2005-6-13-r110 · Cited by 203
van Baarlen, P., van Belkum, A., Summerbell, R. C., Crous, P. W., & Thomma, B. P. H. J. (2007) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2007.00065.x · Cited by 201
Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells
González, C. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2103 · Cited by 196
FUS Interacts with HSP60 to Promote Mitochondrial Damage
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“Therefore, HSP60A, HSP60B and HSP60C have distinct functional activities in development, whereas HSP60D is essential for caspase-mediated apoptosis in Drosophila [78].”
BackgroundInfluentialLigand Receptor Interactions in the Wnt Signaling Pathway inDrosophila
Wu, C.-H., & Nusse, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207850200 · Cited by 190
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Liska, A. J., & Shevchenko, A. (2003) · PROTEOMICS · doi:10.1002/pmic.200390004 · Cited by 189
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Reddy, A. S. N., & Day, I. S. (2001) · Genome biology · doi:10.1186/gb-2001-2-7-research0024 · Cited by 187
Postgenomic Chemical Ecology: From Genetic Code to Ecological Interactions
Berenbaum, M. R. (2002) · Journal of Chemical Ecology · doi:10.1023/a:1015260931034 · Cited by 186
An Ancient Evolutionary Origin of Genes Associated with Human Genetic Diseases
Domazet‐Lošo, T., & Tautz, D. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn214 · Cited by 193
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BackgroundMethodTakahashi, A., Tsaur, S.-C., Coyne, J. A., & Wu, C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061465098 · Cited by 188
Waddell, S., & Quinn, W. G. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1283 · Cited by 184
Serine hydrolase targets of organophosphorus toxicants
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Vogel, C., Teichmann, S. A., & Pereira‐Leal, J. B. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.11.050 · Cited by 185
Greenbaum, D. S., Jansen, R., & Gerstein, M. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.4.585 · Cited by 183
Multiple endocrine neoplasia type 1
Marini, F., Falchetti, A., Monte, F. D., Sala, S. C., Gozzini, A., Luzi, E., & Brandi, M. L. (2006) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-1-38 · Cited by 182
Building Blocks, Cohort Genetic Algorithms, and Hyperplane-Defined Functions
Holland, J. H. (2000) · Evolutionary Computation · doi:10.1162/106365600568220 · Cited by 182
“See for example, Schwab and Pienta (1997), Hutter et al. (2000), Walter et al. (2000), Lander and Weinberg (2000), and Rubin et al. (2000).”
BackgroundBrenner, S. (2000) · Science · doi:10.1126/science.287.5461.2173 · Cited by 180
Gene Duplication and the Structure of Eukaryotic GenomesPreprint
Friedman, R., & Hughes, A. L. (2001) · Genome Research · doi:10.1101/gr.155801 · Cited by 182
“Note that the resulting numbers of families are much lower than those given by Rubin et al. (2000) for the same three species because those authors used E = 10”
BackgroundMukherjee, K., Yang, X., Gerber, S. H., Kwon, H.-B., Ho, A., Castillo, P. E., Liu, X., & Südhof, T. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002307107 · Cited by 195
Dying for a cause: invertebrate genetics takes on human neurodegeneration
Driscoll, M., & Gerstbrein, B. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1018 · Cited by 183
Scabies: New Future for a Neglected Disease
Walton, S. F., Holt, D. C., Currie, B. J., & Kemp, D. J. (2004) · Advances in Parasitology/Advances in parasitology · doi:10.1016/s0065-308x(04)57005-7 · Cited by 177
A genomewide survey of basic helix–loop–helix factors in Drosophila
Moore, A. W., Barbel, S., Jan, L. Y., & Jan, Y. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.170301897 · Cited by 177
Evaluation and classification of RING-finger domains encoded by the Arabidopsis genome
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Control of p53 ubiquitination and nuclear export by MDM2 and ARF.
Zhang, Y., & Xiong, Y. (2001) · PubMed · Cited by 176
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Yuen, K. W. Y., Warren, C. D., Chen, O., Kwok, T., Hieter, P., & Spencer, F. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610642104 · Cited by 170
Novel natural ligands for Drosophila olfactory receptor neurones
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Karev, G. P., Wolf, Y. I., Rzhetsky, A., Berezovskaya, F., & Koonin, E. V. (2002) · BMC Evolutionary Biology · doi:10.1186/1471-2148-2-18 · Cited by 175
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Self-citationA Circadian Output Circuit Controls Sleep-Wake Arousal in Drosophila
Guo, F., Holla, M. R., Díaz, M. M., & Rosbash, M. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.002 · Cited by 173
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Scherer, S., Stocker, R. F., & Gerber, B. (2003) · Learning & Memory · doi:10.1101/lm.57903 · Cited by 174
“On the level of gene homology, flies and mammals share surprisingly many genes (Rubin et al. 2000), suggesting that the molecular mechanisms of behavioral plasticity might be shared.”
16 The evolution of gene duplicates
Otto, S. P., & Yong, P. J. (2002) · Advances in genetics · doi:10.1016/s0065-2660(02)46017-8 · Cited by 173
Vosshall, L. B. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00111-2 · Cited by 172
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Bourbon, H.-M. G., Gonzy-Tréboul, G., Peronnet, F., Alin, M., Ardourel, C., Benassayag, C., Cribbs, D. L., Deutsch, J. S., Ferrer, P., Haenlin, M., et al. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00566-4 · Cited by 172
InterPro: An integrated documentation resource for protein families, domains and functional sites
Mulder, N., Apweiler, R., Attwood, T. K., Bairoch, A., Bateman, A. G., Binns, D., Biswas, M., Bradley, P., Peer Bork, B., Bucher, P., et al. (2002) · Briefings in Bioinformatics · doi:10.1093/bib/3.3.225 · Cited by 171
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Galizia, C. G., & Menzel, R. (2001) · Journal of Insect Physiology · doi:10.1016/s0022-1910(00)00106-2 · Cited by 169
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BackgroundInsect immunity and its implication in mosquito-malaria interactions
Dimopoulos, G. (2003) · Cellular Microbiology · doi:10.1046/j.1462-5822.2003.00252.x · Cited by 168
Panopoulou, G. D., Hennig, S., Groth, D., Krause, A., Poustka, A. J., Herwig, R., Vingron, M., & Lehrach, H. (2003) · Genome Research · doi:10.1101/gr.874803 · Cited by 168
Systems Toxicology and the Chemical Effects in Biological Systems (CEBS) Knowledge Base
Waters, M. D., Boorman, G., Bushel, P., Cunningham, M., Irwin, R., Merrick, A., Olden, K., Paules, R., Selkirk, J., Stasiewicz, S., et al. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.5971 · Cited by 170
Modular Assembly of Genes and the Evolution of New Functions
Patthy, L. (2003) · Genetica · doi:10.1023/a:1024182432483 · Cited by 166
“A comparative analysis of the genomes ofD. melanogaster, C. elegans, and S. cerevisiae (Rubin et al., 2000) has shown that, although the nonredundant protein sets of flies and worms are similar in size (and are only twice that of yeast), the multidomain proteins of the fly and worm are far more…”
BackgroundCross-Species Comparison of Drosophila Male Accessory Gland Protein Genes
Mueller, J. L., Ram, K. R., McGraw, L. A., Qazi, M. C. B., Siggia, E. D., Clark, A. G., Aquadro, C. F., & Wolfner, M. F. (2005) · Genetics · doi:10.1534/genetics.105.043844 · Cited by 166
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Joseph, S., & Hall, D. W. (2004) · Genetics · doi:10.1534/genetics.104.033761 · Cited by 167
Kumar, S., & Doumanis, J. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400756 · Cited by 165
Clifford, R., Lee, M., Nayak, S., Ohmachi, M., Giorgini, F., & Schedl, T. (2000) · Development · doi:10.1242/dev.127.24.5265 · Cited by 164
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Ellegren, H. (2008) · Molecular Ecology · doi:10.1111/j.1365-294x.2008.03954.x · Cited by 162
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BackgroundHomogeneous Glycopeptides and Glycoproteins for Biological Investigation
Grogan, M. J., Pratt, M. R., Marcaurelle, L. A., & Bertozzi, C. R. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135334 · Cited by 163
H UMAN N EURODEGENERATIVE D ISEASE M ODELING U SING D ROSOPHILA
Bonini, N. M., & Fortini, M. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131425 · Cited by 169
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BackgroundSelf-citationMiller, W., Makova, K. D., Nekrutenko, A., & Hardison, R. C. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.180057 · Cited by 165
Kho, A. T., Zhao, Q., Cai, Z., Butte, A. J., Kim, J. Y. H., Pomeroy, S. L., Rowitch, D. H., & Kohane, I. S. (2004) · Genes & Development · doi:10.1101/gad.1182504 · Cited by 160
Self-citationZhang, S., Binari, R., Zhou, R., & Perrimon, N. (2010) · Genetics · doi:10.1534/genetics.109.112516 · Cited by 160
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Wada, S., Tokuoka, M., Shoguchi, E., Kobayashi, K., Gregorio, A. D., Spagnuolo, A., Branno, M., Kohara, Y., Rokhsar, D. S., Levine, M., et al. (2003) · Development Genes and Evolution · doi:10.1007/s00427-003-0321-0 · Cited by 160
Knudson, A. G. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10320 · Cited by 160
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Velarde, R. A., Sauer, C. D., Walden, K. K. O., Fahrbach, S. E., & Robertson, H. M. (2005) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2005.09.001 · Cited by 156
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Genomic drift and copy number variation of sensory receptor genes in humans
Nozawa, M., Kawahara, Y., & Nei, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709956104 · Cited by 157
Tuberous sclerosis complex: from Drosophila to human disease
Pan, D., Dong, J., Zhang, Y., & Gao, X. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2003.12.006 · Cited by 158
Quinn, L. M., Herr, A., McGarry, T. J., & Richardson, H. E. (2001) · Genes & Development · doi:10.1101/gad.916201 · Cited by 158
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MethodNuclear receptors in nematodes: themes and variations
Sluder, A. E. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02242-9 · Cited by 155
Fernández, X. M., & Birney, E. (2009) · Springer eBooks · doi:10.1007/978-3-540-37654-5_45 · Cited by 156
Self-citationEvolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomes
Huang, H., Winter, E. E., Wang, H., Weinstock, K. G., Xing, H., Goodstadt, L., Stenson, P. D., Cooper, D. N., Smith, D., Albà, M. M., et al. (2004) · Genome biology · doi:10.1186/gb-2004-5-7-r47 · Cited by 153
Two-Pore-Domain (Kcnk) Potassium Channels: Dynamic Roles in Neuronal Function
Talley, E. M., Sirois, J. E., Lei, Q., & Bayliss, D. A. (2003) · The Neuroscientist · doi:10.1177/1073858402239590 · Cited by 154
Converging on proline: the mechanism of WW domain peptide recognition.
Zarrinpar, A., & Lim, W. A. (2000) · Nature Structural Biology · doi:10.1038/77891 · Cited by 153
Chemical strategies for the global analysis of protein function
Cravatt, B. F. (2000) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(00)00147-2 · Cited by 153
Duplicate genes and robustness to transient gene knock-downs inCaenorhabditis elegans
Conant, G. C., & Wagner, A. (2004) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2003.2560 · Cited by 152
Genes that fight infection:what the Drosophila genome says about animal immunity
Khush, R. S., & Lemaître, B. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(00)02095-3 · Cited by 155
Compactness of human housekeeping genes: selection for economy or genomic design?
Vinogradov, A. E. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.03.006 · Cited by 165
Katju, V., & Lynch, M. (2003) · Genetics · doi:10.1093/genetics/165.4.1793 · Cited by 151
An absolute requirement for Cubitus interruptus in Hedgehog signaling
Méthot, N., & Basler, K. (2001) · Development · doi:10.1242/dev.128.5.733 · Cited by 151
Homologous DNA recombination in vertebrate cells
Sonoda, E., Takata, M., Yamashita, Y. M., Morrison, C. G., & Takeda, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111006398 · Cited by 151
Current topics in genome evolution: Molecular mechanisms of new gene formation
Babushok, D. V., Ostertag, E. M., & Kazazian, H. H. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6453-4 · Cited by 151
Environmental genomics, the big picture?
Rodríguez‐Valera, F. (2004) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(04)00006-0 · Cited by 150
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Adam, G. C., Cravatt, B. F., & Sorensen, E. J. (2001) · Chemistry & Biology · doi:10.1016/s1074-5521(00)90060-7 · Cited by 151
“Genome sequencing projects have identi- ¢ed numerous ALDHs in Drosophila melanogaster (28 ALDHs), Caenorhabditis elegans (13 ALDHs), and Saccharomyces cerevisiae (13 ALDHs) [ 31 ].”
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Lee, Y., Sultana, R., Pertea, G. M., Cho, J., Karamycheva, S. A., Tsai, J., Parvizi, B., Cheung, F., Antonescu, V., White, J., et al. (2002) · Genome Research · doi:10.1101/gr.212002 · Cited by 150
“We attempted to identify homologs of human disease genes in eukaryotic organisms represented in TOGA using a slightly modified list of 288 human disease genes previously compiled for a survey of the predicted gene in the Drosophila genome (Rubin et al. 2000; Fortini et al. 2001).”
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Vakirlis, N., Carvunis, A., & McLysaght, A. (2020) · eLife · doi:10.7554/elife.53500 · Cited by 143
Zheng, Q. Y., Yan, D. L. S., Ouyang, X. M., Du, L. L., Yu, H., Chang, B., Johnson, K. R., & Liu, X. Z. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddi010 · Cited by 147
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Story, R. M., Li, H., & Abelson, J. N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1465 · Cited by 148
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Self-citationYeast genome duplication was followed by asynchronous differentiation of duplicated genes
Langkjær, R. B., Cliften, P. F., Johnston, M., & Piškur, J. (2003) · Nature · doi:10.1038/nature01419 · Cited by 137
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Scala, S., Carels, N., Falciatore, A., Chiusano, M. L., & Bowler, C. (2002) · PLANT PHYSIOLOGY · doi:10.1104/pp.010713 · Cited by 141
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Eilbeck, K. L., Moore, B., Holt, C., & Yandell, M. D. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-67 · Cited by 140
Self-citationSpectrin, α-Actinin, and Dystrophin
Broderick, M., & Winder, S. J. (2005) · Advances in protein chemistry · doi:10.1016/s0065-3233(05)70007-3 · Cited by 137
Peiren, N., de Graaf, D. C., Vanrobaeys, F., Danneels, E., Devreese, B. V., BEEUMEN, J. V., & Jacobs, F. J. (2008) · Toxicon · doi:10.1016/j.toxicon.2008.05.003 · Cited by 138
Role of the F-Box Protein Skp2 in Adhesion-Dependent Cell Cycle Progression
Carrano, A. C., & Pagano, M. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.7.1381 · Cited by 134
Hulme, S. E., & Whitesides, G. M. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201005461 · Cited by 141
Evolution of Genome Size in Conifers
Ahuja, M. R., & Neale, D. B. (2005) · Silvae genetica/Silvae Genetica · doi:10.1515/sg-2005-0020 · Cited by 142
Conservation and Innovation in Plant Signaling Pathways
McCarty, D. R., & Chory, J. (2000) · Cell · doi:10.1016/s0092-8674(00)00113-6 · Cited by 137
Williamson, M. P., Lenz, C., Winther, Å. M. E., Nässel, D. R., & Grimmelikhuijzen, C. J. P. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4565 · Cited by 137
Large-Scale Transgenic Drosophila Resource Collections for Loss- and Gain-of-Function Studies
Zirin, J. D., Hu, Y., Liu, L., Yang‐Zhou, D., Colbeth, R., Yan, D., Ewen‐Campen, B., Tao, R., Vogt, E., VanNest, S., et al. (2020) · Genetics · doi:10.1534/genetics.119.302964 · Cited by 125
“The relevance of Drosophila to humans is best illustrated by the observations that >60% of human genes associated with diseases have counterparts in Drosophila (Rubin et al. 2000; Hu et al. 2011) and”
BackgroundFumasoni, I., Meani, N., Rambaldi, D., Scafetta, G., Alcalay, M., & Ciccarelli, F. D. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-187 · Cited by 139
Plasmodium, human and Anopheles genomics and malaria
Hoffman, S. L., Subramanian, G., Collins, F. H., & Venter, J. C. (2002) · Nature · doi:10.1038/415702a · Cited by 136
Self-citationCarbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology
Aspatwar, A., Tolvanen, M. E. E., Barker, H. R., Syrjänen, L., Valanne, S., Purmonen, S., Waheed, A., Sly, W. S., & Parkkila, S. (2022) · Physiological Reviews · doi:10.1152/physrev.00018.2021 · Cited by 140
Formation of nNOS/PSD-95 PDZ dimer requires a preformed β-finger structure from the nNOS PDZ domain
Tochio, H., Mok, Y., Zhang, Q., Kan, H.-M., Bredt, D. S., & Zhang, M. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4148 · Cited by 135
Ben‐Shlomo, I., Hsu, S. Y., Rauch, R., Kowalski, H. W., & Hsueh, A. J. W. (2003) · Science Signaling · doi:10.1126/stke.2003.187.re9 · Cited by 139
The Drosophila Melanogaster Genome
Celniker, S., & Rubin, G. M. (2003) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.4.070802.110323 · Cited by 133
Self-citationAsymmetric Functional Divergence of Duplicate Genes in Yeast
Wagner, A. (2002) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a003998 · Cited by 137
“But gene duplications occur continuously and at high rates in eukaryotes, which accounts for the fact that up to 50% of a eukaryotic genome may consist of duplicate genes (Lynch and Conery 2000; Rubin et al. 2000).”
Background
Metadata
- Authors
- Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., Fleischmann, W., Cherry, J. M., Henikoff, S., Skupski, M. P., Misra, S., Ashburner, M., Birney, E., Boguski, M. S., Brody, T., Brokstein, P., Celniker, S. E., Chervitz, S. A., Coates, D., Cravchik, A., Gabrielian, A., Galle, R. F., Gelbart, W. M., George, R. A., Goldstein, L. S. B., Gong, F., Guan, P., Harris, N. L., Hay, B. A., Hoskins, R. A., Li, J., Li, Z., Hynes, R. O., Jones, S. J. M., Kuehl, P. M., Lemaitre, B., Littleton, J. T., Morrison, D. K., Mungall, C., O'Farrell, P. H., Pickeral, O. K., Shue, C., Vosshall, L. B., Zhang, J., Zhao, Q., Zheng, X. H., Zhong, F., Zhong, W., Gibbs, R., Venter, J. C., Adams, M. D., & Lewis, S.
- Affiliations
- Howard Hughes Medical Institute (US)
- Celera Genomics, Rockville, MD, 20850 USA.
- GenetixXpress, 78 Pacific Road, Palm Beach, Sydney, Australia 2108.
- University of California, Berkeley (US)
- Harvard University (US)
- University of Pennsylvania (US)
- European Bioinformatics Institute (GB)
- Stanford University (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- National Institutes of Health (US)
- Lawrence Berkeley National Laboratory (US)
- Neomorphic, 2612 Eighth Street, Berkeley, CA 94710, USA.
- University of Leeds (GB)
- California Institute of Technology (US)
- BC Cancer Agency (CA)
- University of Maryland, Baltimore (US)
- Centre de Génétique Moléculaire, CNRS, 91198 Gif-sur-Yvette, France.
- Massachusetts Institute of Technology (US)
- Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA.
- Columbia University (US)
- Baylor College of Medicine (US)
- ORCID
- Rubin, Gerald M.
- Yandell, Mark D.
- Wortman, Jennifer R.
- Nelson, Catherine R.
- Hariharan, Iswar K.
- Apweiler, Rolf
- Cherry, J. Michael
- Henikoff, Steven
- Ashburner, Michael
- Birney, Ewan
- Celniker, Susan E.
- Chervitz, Stephen A.
- Gabrielian, Andrei
- George, Reed A.
- Goldstein, Lawrence S. B.
- Guan, Ping
- Harris, Nomi L.
- Hay, Bruce A.
- Li, Jiayin
- Hynes, Richard O.
- Jones, S. J. M.
- Littleton, J. Troy
- Morrison, Deborah K.
- Mungall, Chris
- Vosshall, Leslie B.
- Zhang, Jiong
- Zhao, Qi
- Zhong, Fei
- Zhong, Wenyan
- Gibbs, Richard
- Venter, J. Craig
- Adams, Mark D.
- Lewis, Suzanna
- Venue
- Science
- Published
- 2000-03-24
- Volume
- 287
- Issue
- 5461
- Pages
- 2204-2215
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2754258
- OpenAlex
- W2106013076
- Cited by
- 1,698
- References
- 87
- Citations by year
- 2026: 19 · 2025: 26 · 2024: 18 · 2023: 24 · 2022: 30 · 2021: 29 · 2020: 37 · 2019: 33 · 2018: 36 · 2017: 34 · 2016: 34 · 2015: 38 · 2014: 34 · 2013: 45 · 2012: 55
- FWCI
- 75.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Human Genome Research Institute (P50HG000750, P4IHG00739, P50-HG00750)
- National Institute of General Medical Sciences (R01GM037193, R01GM060988)
- National Institute of Neurological Disorders and Stroke (R01NS040296)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- comparative genomics, eukaryotic genomes, Drosophila melanogaster, Caenorhabditis elegans, Saccharomyces cerevisiae, gene family expansion, multidomain proteins, signaling pathways, orthologs, human disease genes, model organisms
- MeSH terms
- Animals, Cell Adhesion, Cell Cycle, Drosophila melanogaster, Biological Evolution, Fungal Proteins, Multigene Family, Genetics, Medical, Humans, Immunity, Neoplasms, Saccharomyces cerevisiae, Signal Transduction, Helminth Proteins, Genome, Caenorhabditis elegans, Apoptosis, Protein Structure, Tertiary, Insect Proteins, Genes, Duplicate, Proteome, Genetic Diseases, Inborn
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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