Cited by 1,698Genomics and Phylogenetic StudiesBioinformatics and Genomic NetworksDevelopmental Biology and Gene Regulation

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Comparative Genomics of the Eukaryotes

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Rubin, Gerald M., Yandell, Mark D., Wortman, Jennifer R., Gabor, George L., Miklos, Nelson, Catherine R., Hariharan, Iswar K., Fortini, Mark E., Li, Peter W., Apweiler, Rolf, Fleischmann, Wolfgang, Cherry, J. Michael, Henikoff, Steven, Skupski, Marian P., Misra, Sima, Ashburner, Michael, Birney, Ewan, Boguski, Mark S., Brody, Thomas, Brokstein, Peter, Celniker, Susan E., Chervitz, Stephen A., Coates, David, Cravchik, Anibal, Gabrielian, Andrei, Galle, Richard F., Gelbart, William M., George, Reed A., Goldstein, Lawrence S. B., Gong, Fangcheng, Guan, Ping, Harris, Nomi L., Hay, Bruce A., Hoskins, Roger A., Li, Jiayin, Li, Zhenya, Hynes, Richard O., Jones, S. J. M., Kuehl, Peter M., Lemaitre, Bruno, Littleton, J. Troy, Morrison, Deborah K., Mungall, Chris, O'Farrell, Patrick H., Pickeral, Oxana K., Shue, Chris, Vosshall, Leslie B., Zhang, Jiong, Zhao, Qi, Zheng, Xiangqun H., Zhong, Fei, Zhong, Wenyan, Gibbs, Richard, Venter, J. Craig, Adams, Mark D., Lewis, Suzanna·2000·Science

DOI 10.1126/science.287.5461.2204PMC PMC2754258

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Abstract

A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.

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Authors: Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., Fleischmann, W., Cherry, J. M., Henikoff, S., Skupski, M. P., Misra, S., Ashburner, M., Birney, E., Boguski, M. S., Brody, T., Brokstein, P., Celniker, S. E., Chervitz, S. A., Coates, D., Cravchik, A., Gabrielian, A., Galle, R. F., Gelbart, W. M., George, R. A., Goldstein, L. S. B., Gong, F., Guan, P., Harris, N. L., Hay, B. A., Hoskins, R. A., Li, J., Li, Z., Hynes, R. O., Jones, S. J. M., Kuehl, P. M., Lemaitre, B., Littleton, J. T., Morrison, D. K., Mungall, C., O'Farrell, P. H., Pickeral, O. K., Shue, C., Vosshall, L. B., Zhang, J., Zhao, Q., Zheng, X. H., Zhong, F., Zhong, W., Gibbs, R., Venter, J. C., Adams, M. D., & Lewis, S.
Affiliations: Howard Hughes Medical Institute (US)
Celera Genomics, Rockville, MD, 20850 USA.
GenetixXpress, 78 Pacific Road, Palm Beach, Sydney, Australia 2108.
University of California, Berkeley (US)
Harvard University (US)
University of Pennsylvania (US)
European Bioinformatics Institute (GB)
Stanford University (US)
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
National Institutes of Health (US)
Lawrence Berkeley National Laboratory (US)
Neomorphic, 2612 Eighth Street, Berkeley, CA 94710, USA.
University of Leeds (GB)
California Institute of Technology (US)
BC Cancer Agency (CA)
University of Maryland, Baltimore (US)
Centre de Génétique Moléculaire, CNRS, 91198 Gif-sur-Yvette, France.
Massachusetts Institute of Technology (US)
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA.
Columbia University (US)
Baylor College of Medicine (US)
ORCID: Rubin, Gerald M.
Yandell, Mark D.
Wortman, Jennifer R.
Nelson, Catherine R.
Hariharan, Iswar K.
Apweiler, Rolf
Cherry, J. Michael
Henikoff, Steven
Ashburner, Michael
Birney, Ewan
Celniker, Susan E.
Chervitz, Stephen A.
Gabrielian, Andrei
George, Reed A.
Goldstein, Lawrence S. B.
Guan, Ping
Harris, Nomi L.
Hay, Bruce A.
Li, Jiayin
Hynes, Richard O.
Jones, S. J. M.
Littleton, J. Troy
Morrison, Deborah K.
Mungall, Chris
Vosshall, Leslie B.
Zhang, Jiong
Zhao, Qi
Zhong, Fei
Zhong, Wenyan
Gibbs, Richard
Venter, J. Craig
Adams, Mark D.
Lewis, Suzanna
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2000-03-24
Volume: 287
Issue: 5461
Pages: 2204-2215
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.287.5461.2204
PMC: PMC2754258
OpenAlex: W2106013076
Cited by: 1,698
References: 87
Citations by year: 2026: 19 · 2025: 26 · 2024: 18 · 2023: 24 · 2022: 30 · 2021: 29 · 2020: 37 · 2019: 33 · 2018: 36 · 2017: 34 · 2016: 34 · 2015: 38 · 2014: 34 · 2013: 45 · 2012: 55
FWCI: 75.40
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders: National Human Genome Research Institute (P50HG000750, P4IHG00739, P50-HG00750)
National Institute of General Medical Sciences (R01GM037193, R01GM060988)
National Institute of Neurological Disorders and Stroke (R01NS040296)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: comparative genomics, eukaryotic genomes, Drosophila melanogaster, Caenorhabditis elegans, Saccharomyces cerevisiae, gene family expansion, multidomain proteins, signaling pathways, orthologs, human disease genes, model organisms
MeSH terms: Animals, Cell Adhesion, Cell Cycle, Drosophila melanogaster, Biological Evolution, Fungal Proteins, Multigene Family, Genetics, Medical, Humans, Immunity, Neoplasms, Saccharomyces cerevisiae, Signal Transduction, Helminth Proteins, Genome, Caenorhabditis elegans, Apoptosis, Protein Structure, Tertiary, Insect Proteins, Genes, Duplicate, Proteome, Genetic Diseases, Inborn

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