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Psychological and Neural Mechanisms of the Affective Dimension of Pain

Price, Donald D.·2000·Science

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Abstract

The affective dimension of pain is made up of feelings of unpleasantness and emotions associated with future implications, termed secondary affect. Experimental and clinical studies show serial interactions between pain sensation intensity, pain unpleasantness, and secondary affect. These pain dimensions and their interactions relate to a central network of brain structures that processes nociceptive information both in parallel and in series. Spinal pathways to limbic structures and medial thalamic nuclei provide direct inputs to brain areas involved in affect. Another source is from spinal pathways to somatosensory thalamic and cortical areas and then through a cortico-limbic pathway. The latter integrates nociceptive input with contextual information and memory to provide cognitive mediation of pain affect. Both direct and cortico-limbic pathways converge on the same anterior cingulate cortical and subcortical structures whose function may be to establish emotional valence and response priorities.

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Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377
Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex
Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997) · Science · doi:10.1126/science.277.5328.968 · Cited by 2,629
Self-citation
Pain intensity processing within the human brain: a bilateral, distributed mechanism
Coghill, R. C., Sang, C. N., Maisog, J. M., & Iadarola, M. J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.4.1934 · Cited by 1,077
Insula of the old world monkey. III: Efferent cortical output and comments on function
Mesulam, M. ‐., & Mufson, E. J. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902120104 · Cited by 1,013
Pain perception: Is there a role for primary somatosensory cortex?
Bushnell, M. C., Duncan, G. H., Hofbauer, R. K., Ha, B., Chen, J.-I., & Carrier, B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7705 · Cited by 736
Cortical connections of the somatosensory fields of the lateral sulcus of macaques: Evidence for a corticolimbic pathway for touch
Friedman, D. P., Murray, E. A., O'Neill, J. B., & Mishkin, M. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902520304 · Cited by 544
Pain Sensations and Reactions
Hardy, J. D. (1953) · Physical Therapy · doi:10.1093/ptj/33.6.327 · Cited by 541
Dissociation of sensory and affective dimensions of pain using hypnotic modulation.
Rainville, P., Carrier, B., Hofbauer, R. K., Bushnell, C. M., & Duncan, G. H. (1999) · Pain · doi:10.1016/s0304-3959(99)00048-2 · Cited by 530
Functional MRI Study of Thalamic and Cortical Activations Evoked by Cutaneous Heat, Cold, and Tactile Stimuli
Davis, K. D., Kwan, C. L., Crawley, A. P., & Mikulis, D. J. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.3.1533 · Cited by 461
Asymbolia for pain: a sensory‐limbic disconnection syndrome
Berthier, M., Starkstein, S., & Leiguarda, R. (1988) · Annals of Neurology · doi:10.1002/ana.410240109 · Cited by 456

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Research works printed but not linked: 3

R. Melzack and K. L. Casey in The Skin Senses D. R. Kenshalo Ed. (Thomas Springfield IL 1968) pp. 423–439.
Wade J. B., Dougherty L. M., Archer C. R., Price D. D., Pain 62, 1 (1996).
A. D. Craig in Forebrain Areas Involved in Pain Processing J.-M. Besson G. Guildbaud H. Ollat Eds. (Eurotext Paris 1995) pp. 13–25.

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Authors: Price, D. D.
Affiliations: University of Florida (US)
Corresponding author: Price, Donald D.
ORCID: Price, Donald D.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2000-06-09
Volume: 288
Issue: 5472
Pages: 1769-1772
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.288.5472.1769
OpenAlex: W2007791604
Cited by: 2,092
References: 25
Citations by year: 2026: 50 · 2025: 67 · 2024: 60 · 2023: 77 · 2022: 95 · 2021: 93 · 2020: 88 · 2019: 114 · 2018: 86 · 2017: 88 · 2016: 102 · 2015: 81 · 2014: 79 · 2013: 103 · 2012: 83
FWCI: 26.10
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (R01 295527912)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: affective dimension of pain, pain unpleasantness, nociception, anterior cingulate cortex, medial thalamic nuclei, emotional valence, pain memory
MeSH terms: Affect, Afferent Pathways, Animals, Brain Mapping, Cerebral Cortex, Humans, Limbic System, Pain, Parietal Lobe, Somatosensory Cortex, Spinal Cord, Thalamic Nuclei, Tomography, Emission-Computed

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Psychological and Neural Mechanisms of the Affective Dimension of Pain

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