Cited by 275Olfactory and Sensory Function StudiesIon Channels and ReceptorsBiochemical Analysis and Sensing Techniques

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Responses of Vomeronasal Neurons to Natural Stimuli

Holy, Timothy E., Dulac, Catherine, Meister, Markus·2000·Science

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Abstract

The vomeronasal organ (VNO) of mammals plays an essential role in the detection of pheromones. We obtained simultaneous recordings of action potentials from large subsets of VNO neurons. These cells responded to components of urine by increasing their firing rate. This chemosensory activation required phospholipase C function. Unlike most other sensory neurons, VNO neurons did not adapt under prolonged stimulus exposure. The full time course of the VNO spiking response is captured by a simple quantitative model of ligand binding. Many individual VNO neurons were strongly selective for either male or female mouse urine, with the effective concentrations differing as much as a thousandfold. These results establish a framework for understanding sensory coding in the vomeronasal system.

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Authors: Holy, T. E., Dulac, C., & Meister, M.
Affiliations: Harvard University (US)
Howard Hughes Medical Institute (US)
Corresponding author: Holy, Timothy E.
ORCID: Holy, Timothy E.
Dulac, Catherine
Meister, Markus
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2000-09
Volume: 289
Issue: 5484
Pages: 1569-1572
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.289.5484.1569
OpenAlex: W1999244078
Cited by: 275
References: 24
Citations by year: 2026: 4 · 2025: 5 · 2024: 9 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 9 · 2019: 1 · 2018: 10 · 2017: 6 · 2016: 8 · 2015: 11 · 2014: 11 · 2013: 16 · 2012: 12
FWCI: 8.13
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords: vomeronasal organ, vomeronasal sensory neurons, pheromone detection, urine, phospholipase C, sensory coding, ligand binding, neuronal firing rate
MeSH terms: Action Potentials, Animals, Chemoreceptor Cells, Female, Kinetics, Ligands, Male, Mice, Inbred DBA, Models, Biological, Neurons, Afferent, Pheromones, Type C Phospholipases, Potassium, Urine, Signal Transduction, Vomeronasal Organ, Mice

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Responses of Vomeronasal Neurons to Natural Stimuli

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