The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Responses of Vomeronasal Neurons to Natural Stimuli
Abstract
The vomeronasal organ (VNO) of mammals plays an essential role in the detection of pheromones. We obtained simultaneous recordings of action potentials from large subsets of VNO neurons. These cells responded to components of urine by increasing their firing rate. This chemosensory activation required phospholipase C function. Unlike most other sensory neurons, VNO neurons did not adapt under prolonged stimulus exposure. The full time course of the VNO spiking response is captured by a simple quantitative model of ligand binding. Many individual VNO neurons were strongly selective for either male or female mouse urine, with the effective concentrations differing as much as a thousandfold. These results establish a framework for understanding sensory coding in the vomeronasal system.
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“Vomeronasal receptors (VRs) detect pheromonal cues emitted during social encounters, leading to the activation of distinct neural ensembles in the vomeronasal organ (VNO) (Dulac and Torello, 2003; Holy et al., 2000; Isogai et al., 2011).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Holy et al., 2000
Citations
Cites
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TRP2: A candidate transduction channel for mammalian pheromone sensory signaling
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How the olfactory system makes sense of scents
Firestein, S. (2001) · Nature · doi:10.1038/35093026 · Cited by 1,261
Loss of Sex Discrimination and Male-Male Aggression in Mice Deficient for TRP2
Stowers, L., Holy, T. E., Meister, M., Dulac, C. G., & Koentges, G. (2002) · Science · doi:10.1126/science.1069259 · Cited by 880
Self-citationMolecular detection of pheromone signals in mammals: from genes to behaviour
Dulac, C. G., & Torello, A. T. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1140 · Cited by 662
Self-citationStructure and function of the vomeronasal system: an update
Halpern, M. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00103-5 · Cited by 639
MHC Class I Peptides as Chemosensory Signals in the Vomeronasal Organ
Leinders‐Zufall, T., Brennan, P., Widmayer, P., Prashanth Chandramani, S., Maul‐Pavicic, A., Jäger, M., Li, X.-H., Breer, H., Zufall, F., & Boehm, T. L. J. (2004) · Science · doi:10.1126/science.1102818 · Cited by 608
Metadata
- Authors
- Holy, T. E., Dulac, C., & Meister, M.
- Affiliations
- Harvard University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Holy, Timothy E.
- Venue
- Science
- Published
- 2000-09
- Volume
- 289
- Issue
- 5484
- Pages
- 1569-1572
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999244078
- Cited by
- 275
- References
- 24
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 9 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 9 · 2019: 1 · 2018: 10 · 2017: 6 · 2016: 8 · 2015: 11 · 2014: 11 · 2013: 16 · 2012: 12
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- vomeronasal organ, vomeronasal sensory neurons, pheromone detection, urine, phospholipase C, sensory coding, ligand binding, neuronal firing rate
- MeSH terms
- Action Potentials, Animals, Chemoreceptor Cells, Female, Kinetics, Ligands, Male, Mice, Inbred DBA, Models, Biological, Neurons, Afferent, Pheromones, Type C Phospholipases, Potassium, Urine, Signal Transduction, Vomeronasal Organ, Mice
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