A Novel Family of Putative Pheromone Receptors in Mammals with a Topographically Organized and Sexually Dimorphic Distribution
Open accessAbstract
Mammals have retained two functionally and anatomically independent collections of olfactory neurons located in the main olfactory epithelium and in the vomeronasal organ (VNO). Pheromones activate the VNO in order to elicit fixed action behaviors and neuroendocrine changes involved in animal reproduction and aggression. Differential screening of cDNA libraries constructed from individual rat VNO neurons has led to the isolation of a novel family of approximately 100 genes encoding seven transmembrane receptors with sequence similarity with Ca2+-sensing and metabotropic glutamate receptors. These genes are likely to encode a novel family of pheromone receptors. Patterns of receptor gene expression suggest that the VNO is organized into discrete and sexually dimorphic functional units that may permit segregation of pheromone signals leading to specific arrays of behaviors and neuroendocrine responses.
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Mammalian species with functional VNOs express two families of genes (V1R and V2R) that appear to code for 'seven transmembrane domain' membrane proteins thought to be the chemoreceptor molecules themselves.
“Recent evidence (Dulac and Axel, 1995;Herrada and Dulac, 1997;Matsunami and Buck, 1997;Ryba and Tirrindelli, 1997) suggests that mammalian species with functional VNOs express two families of genes (V1R and V2R) that appear to code for 'seven transmembrane domain' membrane proteins thought to be the chemoreceptor molecules themselves.”
From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Herrada and Dulac, 1997
Genes similar to the vomeronasal receptor genes are also present in the human genome; those found in initial searches are clearly pseudogenes.
“Genes similar to the vomeronasal receptor genes are also present in the human genome.Those found in initial searches through the genome are clearly pseudogenes (Dulac and Axel, 1995;Herrada and Dulac, 1997), i.e. they have defects in their sequence that would prevent transcription and translation of the expected transmembrane protein.”
From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Herrada and Dulac, 1997
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- Authors
- Herrada, G., & Dulac, C.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Dulac, Catherine
- ORCID
- Dulac, Catherine
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 90
- Issue
- 4
- Pages
- 763-773
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1988182516
- Cited by
- 696
- References
- 3
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 17 · 2023: 12 · 2022: 15 · 2021: 17 · 2020: 17 · 2019: 23 · 2018: 11 · 2017: 9 · 2016: 22 · 2015: 18 · 2014: 25 · 2013: 20 · 2012: 16
- FWCI
- 24.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- pheromone receptors, vomeronasal organ, vomeronasal sensory neurons, sexually dimorphic gene expression, topographic organization, G protein-coupled receptors, olfactory signaling, neuroendocrine response, reproductive behavior, aggression, rats
- MeSH terms
- Aging, Amino Acid Sequence, Animals, Chemoreceptor Cells, Epithelial Cells, Female, Male, Molecular Sequence Data, Neurons, Afferent, Rats, Inbred Lew, Sex Characteristics, Transcription, Genetic, In Situ Hybridization, Vomeronasal Organ, Rats
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