Cited by 293Olfactory and Sensory Function StudiesNeurogenesis and neuroplasticity mechanismsIon Channels and Receptors

A map of pheromone receptor activation in the mammalian brain

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Belluscio, Leonardo, Koentges, Georgy, Axel, Richard, Dulac, Catherine·1999·Cell

Abstract

In mammals, the detection of pheromones is mediated by the vomeronasal system. We have employed gene targeting to visualize the pattern of projections of axons from vomeronasal sensory neurons in the accessory olfactory bulb. Neurons expressing a specific receptor project to multiple glomeruli that reside within spatially restricted domains. The formation of this sensory map in the accessory olfactory bulb and the survival of vomeronasal organ sensory neurons require the expression of pheromone receptors. In addition, we observe individual glomeruli in the accessory olfactory bulb that receive input from more than one type of sensory neuron. These observations indicate that the organization of the vomeronasal sensory afferents is dramatically different from that of the main olfactory system, and these differences have important implications for the logic of olfactory coding in the vomeronasal organ.

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Crossref · 10.1016/s0092-8674(00)80731-x

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  • Axons from VNO neurons expressing a given VR project to multiple glomeruli in the accessory olfactory bulb, where they form synaptic connections with AOB mitral/tufted cells, and AOB mitral cells form synapses within multiple glomeruli.

    “In turn, axons from VNO neurons expressing a given VR project to multiple glomeruli in the accessory olfactory bulb (AOB) (Belluscio et al., 1999; Rodriguez et al., 1999), where they form synaptic connections with AOB mitral/tufted cells, and AOB mitral cells form synapses within multiple glomeruli (Wagner et al., 2006).”
  • VNO neurons expressing a given VR project to multiple and spatially distributed glomeruli in the AOB, while AOB output neurons send dendrites to multiple glomeruli.

    “VNO neurons expressing a given VR project to multiple and spatially distributed glomeruli in the AOB, while AOB output neurons send dendrites to multiple glomeruli (Belluscio et al., 1999; Dulac and Torello, 2003; Wagner et al., 2006).”
  • The distributed non-topographic representation of each stimulus type mirrors the distributed organization in the AOB and suggests that information sorting may further be accomplished through selective projection to downstream regions.

    “Such distributed non-topographic representation of each stimulus type mirrors the distributed organization in the AOB (Belluscio et al., 1999; Rodriguez et al., 1999; Wagner et al., 2006) and suggests that information sorting may further be accomplished through selective projection to downstream regions.”

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Authors
Belluscio, L., Koentges, G., Axel, R., & Dulac, C.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Dulac, Catherine
Venue
Cell
Publisher
Elsevier BV
Published
1999-04
Volume
97
Issue
2
Pages
209-220
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2023631751
Cited by
293
References
24
Citations by year
2026: 6 · 2025: 3 · 2024: 11 · 2023: 8 · 2022: 5 · 2021: 11 · 2020: 9 · 2019: 18 · 2018: 7 · 2017: 6 · 2016: 12 · 2015: 4 · 2014: 8 · 2013: 12 · 2012: 6
FWCI
10.42
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p01ns029832-10)
  • National Cancer Institute (P01CA023767, P01CA-23767-20A1)
  • National Institute of Neurological Disorders and Stroke (NS29832-07)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
pheromone receptors, vomeronasal system, accessory olfactory bulb, vomeronasal sensory neurons, sensory maps, gene targeting, odor coding, vomeronasal organ
MeSH terms
Animals, Axons, Base Sequence, Brain, Brain Mapping, Chemoreceptor Cells, Mice, Mutant Strains, Neural Pathways, Neurons, Olfactory Bulb, DNA Primers, Olfactory Receptor Neurons, Mice, Knockout, Gene Targeting, Vomeronasal Organ, Mice

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